Optineurin suppression causes neuronal cell death via NF-κB pathway.
about
Functional analysis of optineurin and some of its disease-associated mutantsLoss of optineurin in vivo results in elevated cell death and alters axonal trafficking dynamicsA novel amyotrophic lateral sclerosis mutation in OPTN induces ER stress and Golgi fragmentation in vitro.Ubiquilin-2 drives NF-κB activity and cytosolic TDP-43 aggregation in neuronal cells.NP001 regulation of macrophage activation markers in ALS: a phase I clinical and biomarker studyGenetic heterogeneity of amyotrophic lateral sclerosis: implications for clinical practice and research.The Regulatory Machinery of Neurodegeneration in In Vitro Models of Amyotrophic Lateral Sclerosis.OPTN 691_692insAG is a founder mutation causing recessive ALS and increased risk in heterozygotes.NF-κB and IRF1 Induce Endogenous Retrovirus K Expression via Interferon-Stimulated Response Elements in Its 5' Long Terminal RepeatOptineurin insufficiency impairs IRF3 but not NF-κB activation in immune cells.Effects of mutations and deletions in the human optineurin gene.The ER mitochondria calcium cycle and ER stress response as therapeutic targets in amyotrophic lateral sclerosis.Optineurin associates with the podocyte Golgi complex to maintain its structure.Linear ubiquitination is involved in the pathogenesis of optineurin-associated amyotrophic lateral sclerosis.Visual impairment in an optineurin mouse model of primary open-angle glaucoma.P53 Dysfunction in Neurodegenerative Diseases - The Cause or Effect of Pathological Changes?PINK1 signalling rescues amyloid pathology and mitochondrial dysfunction in Alzheimer's disease.661W is a retinal ganglion precursor-like cell line in which glaucoma-associated optineurin mutants induce cell death selectively.Multiple Proteinopathies in Familial ALS Cases With Optineurin Mutations.Identification of optineurin as an interleukin-1 receptor-associated kinase 1-binding protein and its role in regulation of MyD88-dependent signaling.Optineurin: A Coordinator of Membrane-Associated Cargo Trafficking and Autophagy.Dysfunction of Optineurin in Amyotrophic Lateral Sclerosis and Glaucoma.Circadian Rhythm Dysfunction Accelerates Disease Progression in a Mouse Model With Amyotrophic Lateral Sclerosis.Altered Functions and Interactions of Glaucoma-Associated Mutants of Optineurin.Acetylation state of RelA modulated by epigenetic drugs prolongs survival and induces a neuroprotective effect on ALS murine model
P2860
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P2860
Optineurin suppression causes neuronal cell death via NF-κB pathway.
description
2013 nî lūn-bûn
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2013年の論文
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2013年学术文章
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2013年学术文章
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2013年学术文章
@zh-cn
2013年学术文章
@zh-hans
2013年学术文章
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2013年学术文章
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2013年學術文章
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name
Optineurin suppression causes neuronal cell death via NF-κB pathway.
@en
Optineurin suppression causes neuronal cell death via NF-κB pathway.
@nl
type
label
Optineurin suppression causes neuronal cell death via NF-κB pathway.
@en
Optineurin suppression causes neuronal cell death via NF-κB pathway.
@nl
prefLabel
Optineurin suppression causes neuronal cell death via NF-κB pathway.
@en
Optineurin suppression causes neuronal cell death via NF-κB pathway.
@nl
P2093
P2860
P356
P1476
Optineurin suppression causes neuronal cell death via NF-κB pathway
@en
P2093
Hidefumi Ito
Hirofumi Yamashita
Kengo Uemura
Mayumi Akizuki
Ryosuke Takahashi
P2860
P304
P356
10.1111/JNC.12326
P407
P577
2013-06-17T00:00:00Z