about
Solution structure and backbone dynamics of the pleckstrin homology domain of the human protein kinase B (PKB/Akt). Interaction with inositol phosphatesCrystal structure of p14TCL1, an oncogene product involved in T-cell prolymphocytic leukemia, reveals a novel beta-barrel topologyAlternative origin of p13MTCP1-encoding transcripts in mature T-cell proliferations with t(X;14) translocationsJUN oncogene amplification and overexpression block adipocytic differentiation in highly aggressive sarcomasSyntenic relationships between genomic profiles of fiber-induced murine and human malignant mesotheliomaTET2 inactivation results in pleiotropic hematopoietic abnormalities in mouse and is a recurrent event during human lymphomagenesisStreamlined ion torrent PGM-based diagnostics: BRCA1 and BRCA2 genes as a modelIdentification of Akt association and oligomerization domains of the Akt kinase coactivator TCL1VAMP: visualization and analysis of array-CGH, transcriptome and other molecular profiles.Molecular allelokaryotyping of T-cell prolymphocytic leukemia cells with high density single nucleotide polymorphism arrays identifies novel common genomic lesions and acquired uniparental disomyThe TCL1A oncoprotein interacts directly with the NF-kappaB inhibitor IkappaB.Germline mutation in the RAD51B gene confers predisposition to breast cancer.Polarity gene alterations in pure invasive micropapillary carcinomas of the breastCirculating tumor DNA as a non-invasive substitute to metastasis biopsy for tumor genotyping and personalized medicine in a prospective trial across all tumor types.X inactive-specific transcript RNA coating and genetic instability of the X chromosome in BRCA1 breast tumors.The inactive X chromosome is epigenetically unstable and transcriptionally labile in breast cancerMetaplastic breast carcinomas display genomic and transcriptomic heterogeneity [corrected]. .Oxidative stress promotes myofibroblast differentiation and tumour spreading.TCL1 oncogene expression in AIDS-related lymphomas and lymphoid tissues.Cancer-associated SF3B1 mutations affect alternative splicing by promoting alternative branchpoint usage.Germline BAP1 mutations predispose to renal cell carcinomas.Frequent PTEN genomic alterations and activated phosphatidylinositol 3-kinase pathway in basal-like breast cancer cells.STAT3 mutations identified in human hematologic neoplasms induce myeloid malignancies in a mouse bone marrow transplantation model.SF3B1 mutations are associated with alternative splicing in uveal melanoma.Designs and challenges for personalized medicine studies in oncology: focus on the SHIVA trial.Patient-derived xenografts recapitulate molecular features of human uveal melanomas.Circulating tumor DNA and circulating tumor cells in metastatic triple negative breast cancer patients.Detection rate and prognostic value of circulating tumor cells and circulating tumor DNA in metastatic uveal melanoma.Circulating tumor DNA for triple-negative breast cancer diagnosis and treatment decisions.The TCL1 oncoprotein inhibits activation-induced cell death by impairing PKCtheta and ERK pathways.Histo-genomic stratification reveals the frequent amplification/overexpression of CCNE1 and BRD4 genes in non-BRCAness high grade ovarian carcinoma.Mapping of human chromosome 22 by in situ hybridization.Mutation in TTI2 reveals a role for triple T complex in human brain development.High frequency of TP53 mutation in BRCA1 and sporadic basal-like carcinomas but not in BRCA1 luminal breast tumors.Ploidy and large-scale genomic instability consistently identify basal-like breast carcinomas with BRCA1/2 inactivation.Upcoming translational challenges for uveal melanoma.Structural basis for the co-activation of protein kinase B by T-cell leukemia-1 (TCL1) family proto-oncoproteins.Actionable perturbations of damage responses by TCL1/ATM and epigenetic lesions form the basis of T-PLL.The pleiotropic movement disorders phenotype of adult ataxia-telangiectasia.Refined solution structure and backbone dynamics of 15N-labeled C12A-p8MTCP1 studied by NMR relaxation.
P50
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P50
description
hulumtues
@sq
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Marc-Henri Stern
@ast
Marc-Henri Stern
@en
Marc-Henri Stern
@es
Marc-Henri Stern
@nl
Marc-Henri Stern
@sl
type
label
Marc-Henri Stern
@ast
Marc-Henri Stern
@en
Marc-Henri Stern
@es
Marc-Henri Stern
@nl
Marc-Henri Stern
@sl
prefLabel
Marc-Henri Stern
@ast
Marc-Henri Stern
@en
Marc-Henri Stern
@es
Marc-Henri Stern
@nl
Marc-Henri Stern
@sl
P1053
A-2728-2011
P106
P1153
55168356000
P21
P31
P3829
P496
0000-0002-8100-2272