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JAG1 binds NOTCH2
JAG1 binds NOTCH2
Item
http://www.wikidata.org/entity/Q50298659
Q50298659
about
NOTCH2 Activation and Transmission of Signal to the Nucleus
P527
Q45318233-3D9A691D-16F2-4B8D-97CA-B3B13BDFF7BA
P527
JAG1 binds NOTCH2
Item
http://www.wikidata.org/entity/Q50298659
description
An instance of the biological reaction JAG1 binds NOTCH2 in Homo sapiens
@en
biologisch proces
@nl
name
JAG1 binds NOTCH2
@en
type
Item
label
JAG1 binds NOTCH2
@en
prefLabel
JAG1 binds NOTCH2
@en
P2860
Q50298659-3243F47B-DDE3-49F6-80CD-C9BF9E511726
Q50298659-351B8582-2137-4785-9833-7DF468538844
Q50298659-4800F546-F085-474F-AA64-E1D7EAE6640E
Q50298659-4F5686DE-95FC-4B22-9DA3-7053D53845DA
Q50298659-54F0CDD0-370A-4B2C-8A5A-3BEAF768E5CD
Q50298659-894AF73D-BF56-4671-851E-A78E3080761B
Q50298659-B34A52A6-17E5-47EE-9834-A2762CAB6BE5
Q50298659-C4C4362E-0E32-4A6F-A6FE-077A12560A82
Q50298659-CE10BDED-A157-4304-891B-EC3D1EA494CE
Q50298659-EA4A3366-6CEA-42E6-9498-4FB92AD6D6CC
P2888
Q50298659-5B0229F5-F28C-43F8-9DF2-113C4E054404
P31
Q50298659-26A06CB5-6A5A-4DE0-8F7D-25069CB2521A
P361
Q50298659-898B08B2-2E6D-453E-8403-D2A5FCE42327
P3937
Q50298659-0485409F-8D51-4EFA-8B2C-FEE4B002EF79
P527
Q50298659-21D5A0CC-2306-4613-9398-777D6A0F5A84
Q50298659-36B84880-9A89-4365-B325-6BCDEE41B64F
Q50298659-6BED6DE6-BDAF-4011-B097-ED4156DD811D
P703
Q50298659-641E5F53-75E2-4F00-8F5B-A0F381E1DDDA
P2860
NOTCH2 mutations cause Alagille syndrome, a heterogeneous disorder of the notch signaling pathway
Mutations in the human Jagged1 gene are responsible for Alagille syndrome
Alagille syndrome is caused by mutations in human Jagged1, which encodes a ligand for Notch1
Binding of Delta1, Jagged1, and Jagged2 to Notch2 rapidly induces cleavage, nuclear translocation, and hyperphosphorylation of Notch2
Mouse jagged1 physically interacts with notch2 and other notch receptors. Assessment by quantitative methods
A mouse model of Alagille syndrome: Notch2 as a genetic modifier of Jag1 haploinsufficiency
Defects in development of the kidney, heart and eye vasculature in mice homozygous for a hypomorphic Notch2 mutation
Glomerular mesangiolipidosis in Alagille syndrome (arteriohepatic dysplasia)
Hepatic ductular hypoplasia associated with characteristic facies, vertebral malformations, retarded physical, mental, and sexual development, and cardiac murmur
Fringe differentially modulates Jagged1 and Delta1 signalling through Notch1 and Notch2.
P2888
reactome:R-HSA-1980056
P31
biological process
P361
NOTCH2 Activation and Transmission of Signal to the Nucleus
P3937
R-HSA-1980056
http://www.w3.org/2001/XMLSchema#string
P527
Jagged canonical Notch ligand 1
NOTCH2/Fringe-modified NOTCH2
JAG1:NOTCH2
P703
Homo sapiens