about
TAPP1 and TAPP2 are targets of phosphatidylinositol 3-kinase signaling in B cells: sustained plasma membrane recruitment triggered by the B-cell antigen receptorTAPP2 links phosphoinositide 3-kinase signaling to B-cell adhesion through interaction with the cytoskeletal protein utrophin: expression of a novel cell adhesion-promoting complex in B-cell leukemiaThe tandem PH domain-containing protein 2 (TAPP2) regulates chemokine-induced cytoskeletal reorganization and malignant B cell migrationThe adaptor protein Bam32 regulates Rac1 activation and actin remodeling through a phosphorylation-dependent mechanism.The B cell adaptor molecule Bam32 is critically important for optimal antibody response and resistance to Trypanosoma congolense infection in mice.Role of the adaptor proteins Bam32, TAPP1 and TAPP2 in lymphocyte activation.The phosphoinositide 3-kinase signaling pathway in normal and malignant B cells: activation mechanisms, regulation and impact on cellular functions.Gefitinib targets ZAP-70-expressing chronic lymphocytic leukemia cells and inhibits B-cell receptor signaling.Phosphoinositide 3-kinase-regulated adapters in lymphocyte activation.Phosphatidylinositol (3,4) bisphosphate-specific phosphatases and effector proteins: A distinct branch of PI3K signaling.FcγRIIB-Independent Mechanisms Controlling Membrane Localization of the Inhibitory Phosphatase SHIP in Human B Cells.Regulation of immune cell signaling by SHIP1: A phosphatase, scaffold protein, and potential therapeutic target.Phosphatidylinositol-3,4-Bisphosphate and Its Binding Protein Lamellipodin Regulate Chemotaxis of Malignant B Lymphocytes.PI(3,4,5)P3 and PI(3,4)P2 levels correlate with PKB/akt phosphorylation at Thr308 and Ser473, respectively; PI(3,4)P2 levels determine PKB activity.Regulation of phosphoinositide 3-kinase signaling by oxidants: hydrogen peroxide selectively enhances immunoreceptor-induced recruitment of phosphatidylinositol (3,4) bisphosphate-binding PH domain proteins.The PH domain adaptor protein Bam32/DAPP1 functions in mast cells to restrain FcɛRI-induced calcium flux and granule release.Bam32/DAPP1 promotes B cell adhesion and formation of polarized conjugates with T cells.The pleckstrin homology domain adaptor protein Bam32/DAPP1 is required for germinal center progression.Genetic or pharmaceutical blockade of p110delta phosphoinositide 3-kinase enhances IgE production.Analysis of CCR7 mediated T cell transfectant migration using a microfluidic gradient generator.B-cell-intrinsic function of TAPP adaptors in controlling germinal center responses and autoantibody production in mice.Differential expression and function of CD27 in chronic lymphocytic leukemia cells expressing ZAP-70.Interaction of TAPP adapter proteins with phosphatidylinositol (3,4)-bisphosphate regulates B-cell activation and autoantibody production.Distinct roles for phosphoinositide 3-kinases γ and δ in malignant B cell migration.The p110delta isoform of phosphatidylinositol 3-kinase controls susceptibility to Leishmania major by regulating expansion and tissue homing of regulatory T cells.ZAP70 expression directly promotes chronic lymphocytic leukaemia cell adhesion to bone marrow stromal cells.Association of interleukin-6 and interleukin-8 with poor prognosis in elderly patients with chronic lymphocytic leukemiaUnderstanding patterns of immunoglobulin gene rearrangementsA novel hypoxia-inducible spliced variant of mitochondrial death gene Bnip3 promotes survival of ventricular myocytesp110δ phosphoinositide 3-kinase represses IgE switch by potentiating BCL6 expressionFollicular dendritic cell secreted protein FDC-SP controls IgA productionTAPP Adaptors Control B Cell Metabolism by Modulating the Phosphatidylinositol 3-Kinase Signaling Pathway: A Novel Regulatory Circuit Preventing AutoimmunityIn-depth PtdIns(3,4,5)P3 signalosome analysis identifies DAPP1 as a negative regulator of GPVI-driven platelet functionIgA levels at diagnosis predict for infections, time to treatment, and survival in chronic lymphocytic leukemiaExpression and function of phosphoinositide 3-kinase delta in mesenchymal stromal cells from normal and leukaemic bone marrow
P50
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description
hulumtues
@sq
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Aaron J Marshall
@es
Aaron J Marshall
@nl
Aaron J Marshall
@sl
Aaron J. Marshall
@en
type
label
Aaron J Marshall
@es
Aaron J Marshall
@nl
Aaron J Marshall
@sl
Aaron J. Marshall
@en
prefLabel
Aaron J Marshall
@es
Aaron J Marshall
@nl
Aaron J Marshall
@sl
Aaron J. Marshall
@en
P106
P1153
35597382900
P21
P31
P496
0000-0002-1175-5498