PI(3,4,5)P3 and PI(3,4)P2 levels correlate with PKB/akt phosphorylation at Thr308 and Ser473, respectively; PI(3,4)P2 levels determine PKB activity.
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Inpp5f is a polyphosphoinositide phosphatase that regulates cardiac hypertrophic responsivenessRegulation of PI3K effector signalling in cancer by the phosphoinositide phosphatasesSingle prolonged stress enhances hippocampal glucocorticoid receptor and phosphorylated protein kinase B levelsProtein kinase A regulates 3-phosphatidylinositide dynamics during platelet-derived growth factor-induced membrane ruffling and chemotaxisMolecular identification for epigallocatechin-3-gallate-mediated antioxidant intervention on the H2O2-induced oxidative stress in H9c2 rat cardiomyoblastsEpigenetic inactivation of inositol polyphosphate 4-phosphatase B (INPP4B), a regulator of PI3K/AKT signaling pathway in EBV-associated nasopharyngeal carcinomaMurine pancreatic adenocarcinoma dampens SHIP-1 expression and alters MDSC homeostasis and functionInositol polyphosphate 4-phosphatase II regulates PI3K/Akt signaling and is lost in human basal-like breast cancersDecreased expression and androgen regulation of the tumor suppressor gene INPP4B in prostate cancer.INPP4B: the new kid on the PI3K block.SHIP1 regulates MSC numbers and their osteolineage commitment by limiting induction of the PI3K/Akt/β-catenin/Id2 axis.A mathematical model of CR3/TLR2 crosstalk in the context of Francisella tularensis infection.A screen for novel phosphoinositide 3-kinase effector proteins.Discovery and development of small molecule SHIP phosphatase modulators.Whole genome sequencing reveals potential targets for therapy in patients with refractory KRAS mutated metastatic colorectal cancer.Therapeutic potential of SH2 domain-containing inositol-5'-phosphatase 1 (SHIP1) and SHIP2 inhibition in cancerThe phosphoinositide 3-kinase signaling pathway in normal and malignant B cells: activation mechanisms, regulation and impact on cellular functions.Involvement of Akt, Ras and cell cycle regulators in the potential development of endometrial hyperplasia in women with polycystic ovarian syndrome.Gene expression of INPP5F as an independent prognostic marker in fludarabine-based therapy of chronic lymphocytic leukemia.INPP4B is upregulated and functions as an oncogenic driver through SGK3 in a subset of melanomas.PI(4,5)P2 5-phosphatase A regulates PI3K/Akt signalling and has a tumour suppressive role in human melanomaCharacterization of AQX-1125, a small-molecule SHIP1 activator: Part 1. Effects on inflammatory cell activation and chemotaxis in vitro and pharmacokinetic characterization in vivoINPP4B is an oncogenic regulator in human colon cancer.Loss of PI(4,5)P2 5-Phosphatase A Contributes to Resistance of Human Melanoma Cells to RAF/MEK Inhibitors.The PIKfyve-ArPIKfyve-Sac3 triad in human breast cancer: Functional link between elevated Sac3 phosphatase and enhanced proliferation of triple negative cell lines.From guidance signals to movement: signaling molecules governing growth cone turning.Akt signaling in platelets and thrombosis.Inhibitor and activator: dual functions for SHIP in immunity and cancer.Phosphoinositide 3-kinase and INPP4B in human breast cancer.Role of inositol poly-phosphatases and their targets in T cell biology.Regulation of immune cell signaling by SHIP1: A phosphatase, scaffold protein, and potential therapeutic target.Neomorphic mutations create therapeutic challenges in cancer.Silencing of CDK2, but not CDK1, separates mitogenic from anti-apoptotic signaling, sensitizing p53 defective cells for synthetic lethality.Urban particulate matter causes ER stress and the unfolded protein response in human lung cells.Mechanism of activation of PKB/Akt by the protein phosphatase inhibitor Calyculin A.AGC family kinase 1 participates in trogocytosis but not in phagocytosis in Entamoeba histolytica.Analysis of genes involved in the PI3K/Akt pathway in radiation- and MNU-induced rat mammary carcinomasBlocking Epidermal Growth Factor Receptor Signaling in HTR-8/SVneo First Trimester Trophoblast Cells Results in Dephosphorylation of PKBα/AKT and Induces Apoptosis.Cocaine regulates protein kinase B and glycogen synthase kinase-3 activity in selective regions of rat brain.miR-181 elevates Akt signaling by co-targeting PHLPP2 and INPP4B phosphatases in luminal breast cancer.
P2860
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P2860
PI(3,4,5)P3 and PI(3,4)P2 levels correlate with PKB/akt phosphorylation at Thr308 and Ser473, respectively; PI(3,4)P2 levels determine PKB activity.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
PI(3,4,5)P3 and PI(3,4)P2 leve ...... levels determine PKB activity.
@en
type
label
PI(3,4,5)P3 and PI(3,4)P2 leve ...... levels determine PKB activity.
@en
prefLabel
PI(3,4,5)P3 and PI(3,4)P2 leve ...... levels determine PKB activity.
@en
P2093
P1433
P1476
PI(3,4,5)P3 and PI(3,4)P2 leve ...... levels determine PKB activity
@en
P2093
Samuel M Cheung
Vincent Duronio
P304
P356
10.1016/J.CELLSIG.2007.12.004
P577
2007-12-08T00:00:00Z