Intrinsic nuclear import activity of geminin is essential to prevent re-initiation of DNA replication in Xenopus eggs.
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Two E3 ubiquitin ligases, SCF-Skp2 and DDB1-Cul4, target human Cdt1 for proteolysis.Regulation of replication licensing by acetyltransferase Hbo1.Genome-wide mapping of DNA synthesis in Saccharomyces cerevisiae reveals that mechanisms preventing reinitiation of DNA replication are not redundant.Selective killing of cancer cells by suppression of geminin activityPreventing re-replication of chromosomal DNA.Quaternary structure of the human Cdt1-Geminin complex regulates DNA replication licensingSCF-FBXO31 E3 ligase targets DNA replication factor Cdt1 for proteolysis in the G2 phase of cell cycle to prevent re-replication.CDK1-dependent inhibition of the E3 ubiquitin ligase CRL4CDT2 ensures robust transition from S Phase to Mitosis.Cdt1 revisited: complex and tight regulation during the cell cycle and consequences of deregulation in mammalian cells.A Cdt1-geminin complex licenses chromatin for DNA replication and prevents rereplication during S phase in Xenopus.Mechanism of CRL4(Cdt2), a PCNA-dependent E3 ubiquitin ligaseGeminin overexpression prevents the completion of topoisomerase IIα chromosome decatenation, leading to aneuploidy in human mammary epithelial cellsThe ATR-mediated S phase checkpoint prevents rereplication in mammalian cells when licensing control is disrupted.Dynamic interactions of high Cdt1 and geminin levels regulate S phase in early Xenopus embryos.The CRL4Cdt2 ubiquitin ligase targets the degradation of p21Cip1 to control replication licensing.Repression of nascent strand elongation by deregulated Cdt1 during DNA replication in Xenopus egg extracts.Geminin stabilizes Cdt1 during meiosis in Xenopus oocytes.Regulation of DNA Replication in Early Embryonic Cleavages.Molecular mechanisms of DNA replication checkpoint activationFlipping the switch from g1 to s phase with e3 ubiquitin ligasesMechanisms and regulation of DNA replication initiation in eukaryotes.The N-terminal noncatalytic region of Xenopus RecQ4 is required for chromatin binding of DNA polymerase alpha in the initiation of DNA replication.Deregulated replication licensing causes DNA fragmentation consistent with head-to-tail fork collision.Cell cycle-dependent subcellular translocation of the human DNA licensing inhibitor geminin.ELYS/MEL-28 chromatin association coordinates nuclear pore complex assembly and replication licensingRegulation of geminin functions by cell cycle-dependent nuclear-cytoplasmic shuttlingCdt1 proteolysis is promoted by dual PIP degrons and is modulated by PCNA ubiquitylation.Cell Cycle Synchronization in Xenopus Egg Extracts.Caenorhabditis elegans geminin homologue participates in cell cycle regulation and germ line development.Inter-origin cooperativity of geminin action establishes an all-or-none switch for replication origin licensing.Subcellular translocation signals regulate Geminin activity during embryonic development.
P2860
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P2860
Intrinsic nuclear import activity of geminin is essential to prevent re-initiation of DNA replication in Xenopus eggs.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年学术文章
@wuu
2005年学术文章
@zh
2005年学术文章
@zh-cn
2005年学术文章
@zh-hans
2005年学术文章
@zh-my
2005年学术文章
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2005年學術文章
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2005年學術文章
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name
Intrinsic nuclear import activ ...... A replication in Xenopus eggs.
@en
Intrinsic nuclear import activ ...... A replication in Xenopus eggs.
@nl
type
label
Intrinsic nuclear import activ ...... A replication in Xenopus eggs.
@en
Intrinsic nuclear import activ ...... A replication in Xenopus eggs.
@nl
prefLabel
Intrinsic nuclear import activ ...... A replication in Xenopus eggs.
@en
Intrinsic nuclear import activ ...... A replication in Xenopus eggs.
@nl
P2093
P1433
P1476
Intrinsic nuclear import activ ...... A replication in Xenopus eggs.
@en
P2093
Haruhiko Takisawa
Kazumasa Yoshida
Yumiko Kubota
P2860
P356
10.1111/J.1365-2443.2005.00815.X
P577
2005-01-01T00:00:00Z