Cdt1 revisited: complex and tight regulation during the cell cycle and consequences of deregulation in mammalian cells. - Wikidata - awgldk - TriplyDB

Cdt1 revisited: complex and tight regulation during the cell cycle and consequences of deregulation in mammalian cells.

Cdt1 revisited: complex and tight regulation during the cell cycle and consequences of deregulation in mammalian cells.

http://www.wikidata.org/entity/Q35107397

about

A WD-repeat protein stabilizes ORC binding to chromatin Prevention of DNA re-replication in eukaryotic cells Selective killing of cancer cells by suppression of geminin activity Regulation and Function of Cdt1; A Key Factor in Cell Proliferation and Genome Stability CDC6: from DNA replication to cell cycle checkpoints and oncogenesis Cul4A is required for hematopoietic cell viability and its deficiency leads to apoptosis Origin licensing and p53 status regulate Cdk2 activity during G(1).Expression profiling of colorectal cancer cells reveals inhibition of DNA replication licensing by extracellular calcium.Cell cycle G2/M arrest through an S phase-dependent mechanism by HIV-1 viral protein R.SCF-FBXO31 E3 ligase targets DNA replication factor Cdt1 for proteolysis in the G2 phase of cell cycle to prevent re-replication.The NEDD8 Conjugation Pathway and Its Relevance in Cancer Biology and Therapy.Life without geminin.Chromatin remodeler sucrose nonfermenting 2 homolog (SNF2H) is recruited onto DNA replication origins through interaction with Cdc10 protein-dependent transcript 1 (Cdt1) and promotes pre-replication complex formation.Stealing the spotlight: CUL4-DDB1 ubiquitin ligase docks WD40-repeat proteins to destroy.Cdc6 stability is regulated by the Huwe1 ubiquitin ligase after DNA damage Identification of novel human Cdt1-binding proteins by a proteomics approach: proteolytic regulation by APC/CCdh1 Chromatin-associated degradation is defined by UBXN-3/FAF1 to safeguard DNA replication fork progression.Human papillomavirus E7 induces rereplication in response to DNA damage Neddylation inhibitor MLN4924 suppresses growth and migration of human gastric cancer cells.Cdt1 and Cdc6 are destabilized by rereplication-induced DNA damage.Characterization of conserved arginine residues on Cdt1 that affect licensing activity and interaction with Geminin or Mcm complex.Repression of nascent strand elongation by deregulated Cdt1 during DNA replication in Xenopus egg extracts.DNA licensing as a novel androgen receptor mediated therapeutic target for prostate cancer.ATM regulates Cdt1 stability during the unperturbed S phase to prevent re-replication.Regulation of the g1/s transition in hepatocytes: involvement of the cyclin-dependent kinase cdk1 in the DNA replication.Targeting mitotic pathways for endocrine-related cancer therapeutics.ATM in prevention of genomic instability.DUB3 and USP7 de-ubiquitinating enzymes control replication inhibitor Geminin: molecular characterization and associations with breast cancer.The pathological consequences of impaired genome integrity in humans; disorders of the DNA replication machinery.Thymosin beta-4 knockdown in IEC-6 normal intestinal epithelial cells induces DNA re-replication via downregulating Emi1.Cell cycle regulator geminin is dispensable for the proliferation of vascular smooth muscle cells.Anti-proliferative effects of physiological concentrations of enterolactone in models of prostate tumourigenesis.Dynamic association of ORCA with prereplicative complex components regulates DNA replication initiation.Adaptive auto-regulation of androgen receptor provides a paradigm shifting rationale for bipolar androgen therapy (BAT) for castrate resistant human prostate cancer.Mutations in Cullin 4B result in a human syndrome associated with increased camptothecin-induced topoisomerase I-dependent DNA breaks Persistent p21 expression after Nutlin-3a removal is associated with senescence-like arrest in 4N cells.Transient nutlin-3a treatment promotes endoreduplication and the generation of therapy-resistant tetraploid cells ATPase-dependent quality control of DNA replication origin licensing.Cyclin A2-cyclin-dependent kinase 2 cooperates with the PLK1-SCFbeta-TrCP1-EMI1-anaphase-promoting complex/cyclosome axis to promote genome reduplication in the absence of mitosis Orc2 protects ORCA from ubiquitin-mediated degradation.

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Cdt1 revisited: complex and tight regulation during the cell cycle and consequences of deregulation in mammalian cells.

http://www.wikidata.org/entity/Q35107397

description

2006 nî lūn-bûn

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2006 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

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2006 թվականի հոտեմբերին հրատարակված գիտական հոդված

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2006年の論文

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2006年論文

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2006年論文

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2006年論文

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2006年論文

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2006年論文

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2006年论文

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name

Cdt1 revisited: complex and ti ...... regulation in mammalian cells.

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Cdt1 revisited: complex and ti ...... regulation in mammalian cells.

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Cdt1 revisited: complex and ti ...... regulation in mammalian cells.

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Cdt1 revisited: complex and ti ...... regulation in mammalian cells.

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Cdt1 revisited: complex and ti ...... regulation in mammalian cells.

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Cdt1 revisited: complex and ti ...... regulation in mammalian cells.

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Masatoshi Fujita

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P2860

Inhibition of eukaryotic DNA replication by geminin binding to Cdt1

Human origin recognition complex large subunit is degraded by ubiquitin-mediated proteolysis after initiation of DNA replication

A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1

Two E3 ubiquitin ligases, SCF-Skp2 and DDB1-Cul4, target human Cdt1 for proteolysis.

Geminin, an inhibitor of DNA replication, is degraded during mitosis

Direct interaction of geminin and Six3 in eye development

Human CDC6/Cdc18 associates with Orc1 and cyclin-cdk and is selectively eliminated from the nucleus at the onset of S phase

Cdt1 phosphorylation by cyclin A-dependent kinases negatively regulates its function without affecting geminin binding

A DNA helicase activity is associated with an MCM4, -6, and -7 protein complex

Geminin regulates neuronal differentiation by antagonizing Brg1 activity

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10.1186/1747-1028-1-22

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Masatoshi Fujita

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