Interferons direct Th2 cell reprogramming to generate a stable GATA-3(+)T-bet(+) cell subset with combined Th2 and Th1 cell functions.
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Cutting edge: Type I IFN reverses human Th2 commitment and stability by suppressing GATA3T helper 17 cell heterogeneity and pathogenicity in autoimmune diseaseFate mapping of IL-17-producing T cells in inflammatory responsesGenomic views of STAT function in CD4+ T helper cell differentiationT Helper Subsets, Peripheral Plasticity, and the Acute Phase Protein, α1-AntitrypsinCytokine reporter mice: the special case of IL-10Toll-like receptor ligands LPS and poly (I:C) exacerbate airway hyperresponsiveness in a model of airway allergy in mice, independently of inflammationMechanisms underlying helper T-cell plasticity: implications for immune-mediated disease.T Helper Lymphocyte Subsets and Plasticity in Autoimmunity and Cancer: An OverviewOrigin and functions of pro-inflammatory cytokine producing Foxp3+ regulatory T cellsMolecular mechanisms that control the expression and activity of Bcl-6 in TH1 cells to regulate flexibility with a TFH-like gene profileT-bet represses T(H)17 differentiation by preventing Runx1-mediated activation of the gene encoding RORγtImmunophenotyping of circulating T helper cells argues for multiple functions and plasticity of T cells in vivo in humans--possible role in asthmaGATA-3 expression identifies a high-risk subset of PTCL, NOS with distinct molecular and clinical features.Combination of metformin and curcumin targets breast cancer in mice by angiogenesis inhibition, immune system modulation and induction of p53 independent apoptosis.Diversity and plasticity of Th cell types predicted from regulatory network modelling.Th2/1 Hybrid Cells Occurring in Murine and Human Strongyloidiasis Share Effector Functions of Th1 CellsRespiratory syncytial virus interferon antagonist NS1 protein suppresses and skews the human T lymphocyte responseConversion of Th2 memory cells into Foxp3+ regulatory T cells suppressing Th2-mediated allergic asthmaEffector T cell plasticity: flexibility in the face of changing circumstancesComplex interactions of transcription factors in mediating cytokine biology in T cells.A novel subset of CD4(+) T(H)2 memory/effector cells that produce inflammatory IL-17 cytokine and promote the exacerbation of chronic allergic asthma.Transcriptional and epigenetic control of T helper cell specification: molecular mechanisms underlying commitment and plasticity.Helper T cell diversity and plasticityPeripheral CD4+ T-cell differentiation regulated by networks of cytokines and transcription factors.A simple theoretical framework for understanding heterogeneous differentiation of CD4+ T cells.Master regulators or lineage-specifying? Changing views on CD4+ T cell transcription factorsHelper T cell plasticity: impact of extrinsic and intrinsic signals on transcriptomes and epigenomes.An animated landscape representation of CD4+ T-cell differentiation, variability, and plasticity: insights into the behavior of populations versus cellsCharacterization of humoral and cellular immunity to rubella vaccine in four distinct cohorts.Development of asthmatic response upon bronchial allergen challenge is associated with dynamic changes of interleukin-10-producing and interleukin-10-responding CD4+ T cells.A unique DNA methylation signature defines a population of IFN-γ/IL-4 double-positive T cells during helminth infection.Systems modeling of molecular mechanisms controlling cytokine-driven CD4+ T cell differentiation and phenotype plasticity.Synergy between CD8 T cells and Th1 or Th2 polarised CD4 T cells for adoptive immunotherapy of brain tumoursInduction and function of virus-specific CD4+ T cell responses.Mapping differentiation under mixed culture conditions reveals a tunable continuum of T cell fatesStochastic cytokine expression induces mixed T helper cell States.Hybrid T-helper cells: stabilizing the moderate center in a polarized system.Stable T-bet(+)GATA-3(+) Th1/Th2 hybrid cells arise in vivo, can develop directly from naive precursors, and limit immunopathologic inflammation.Viral persistence redirects CD4 T cell differentiation toward T follicular helper cells
P2860
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P2860
Interferons direct Th2 cell reprogramming to generate a stable GATA-3(+)T-bet(+) cell subset with combined Th2 and Th1 cell functions.
description
2010 nî lūn-bûn
@nan
2010年の論文
@ja
2010年学术文章
@wuu
2010年学术文章
@zh
2010年学术文章
@zh-cn
2010年学术文章
@zh-hans
2010年学术文章
@zh-my
2010年学术文章
@zh-sg
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2010年學術文章
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name
Interferons direct Th2 cell reprogramming to generate a stable GATA-3
@nl
Interferons direct Th2 cell re ...... ed Th2 and Th1 cell functions.
@en
type
label
Interferons direct Th2 cell reprogramming to generate a stable GATA-3
@nl
Interferons direct Th2 cell re ...... ed Th2 and Th1 cell functions.
@en
prefLabel
Interferons direct Th2 cell reprogramming to generate a stable GATA-3
@nl
Interferons direct Th2 cell re ...... ed Th2 and Th1 cell functions.
@en
P2093
P1433
P1476
Interferons direct Th2 cell re ...... ed Th2 and Th1 cell functions.
@en
P2093
Ahmed N Hegazy
Andreas Radbruch
Anja Fröhlich
Caroline Helmstetter
Daniel D Pinschewer
Isabel Panse
Lukas Flatz
Max Löhning
Michael Peine
P304
P356
10.1016/J.IMMUNI.2009.12.004
P407
P577
2010-01-14T00:00:00Z