Amyloid-β protein (Aβ) Glu11 is the major β-secretase site of β-site amyloid-β precursor protein-cleaving enzyme 1(BACE1), and shifting the cleavage site to Aβ Asp1 contributes to Alzheimer pathogenesis.

Amyloid-β protein (Aβ) Glu11 is the major β-secretase site of β-site amyloid-β precursor protein-cleaving enzyme 1(BACE1), and shifting the cleavage site to Aβ Asp1 contributes to Alzheimer pathogenesis.

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The role of APP and BACE1 trafficking in APP processing and amyloid-β generation The anti-diabetic drug metformin reduces BACE1 protein level by interfering with the MID1 complex Role of berberine in Alzheimer's disease Two novel DNA motifs are essential for BACE1 gene transcription High glucose promotes Aβ production by inhibiting APP degradation.Autophagy dysfunction upregulates beta-amyloid peptides via enhancing the activity of γ-secretase complex.Regulation of global gene expression and cell proliferation by APP Outstanding Phenotypic Differences in the Profile of Amyloid-β between Tg2576 and APPswe/PS1dE9 Transgenic Mouse Models of Alzheimer's Disease.Metabolic Dysfunction of Astrocyte: An Initiating Factor in Beta-amyloid Pathology?Evidence For and Against a Pathogenic Role of Reduced γ-Secretase Activity in Familial Alzheimer's Disease.A Greek Tragedy: The Growing Complexity of Alzheimer Amyloid Precursor Protein Proteolysis.Upregulation of SET expression by BACE1 and its implications in Down syndrome.Modifications and Trafficking of APP in the Pathogenesis of Alzheimer's Disease.Overexpression of ubiquitin carboxyl-terminal hydrolase L1 (UCHL1) delays Alzheimer's progression in vivo.Ethanol Alters APP Processing and Aggravates Alzheimer-Associated Phenotypes.Traumatic Brain Injury Alters the Metabolism and Facilitates Alzheimer's Disease in a Murine Model.Marginal vitamin A deficiency facilitates Alzheimer's pathogenesis.A Novel Alzheimer-Associated SNP in Tmp21 Increases Amyloidogenesis.Early Life Stress and Epigenetics in Late-onset Alzheimer's Dementia: A Systematic Review BACE1 gene silencing alleviates isoflurane anesthesia‑induced postoperative cognitive dysfunction in immature rats by activating the PI3K/Akt signaling pathway Dysregulation of Neuronal Iron Homeostasis as an Alternative Unifying Effect of Mutations Causing Familial Alzheimer's Disease

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P2860

Amyloid-β protein (Aβ) Glu11 is the major β-secretase site of β-site amyloid-β precursor protein-cleaving enzyme 1(BACE1), and shifting the cleavage site to Aβ Asp1 contributes to Alzheimer pathogenesis.

Item

http://www.wikidata.org/entity/Q50902089

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2013 nî lūn-bûn

@nan

2013年の論文

@ja

2013年学术文章

@wuu

2013年学术文章

@zh

2013年学术文章

@zh-cn

2013年学术文章

@zh-hans

2013年学术文章

@zh-my

2013年学术文章

@zh-sg

2013年學術文章

@yue

2013年學術文章

@zh-hant

name

Amyloid-β protein (Aβ) Glu11 i ...... tes to Alzheimer pathogenesis.

@en

Amyloid-β protein (Aβ) Glu11 i ...... tes to Alzheimer pathogenesis.

@nl

type

Item

label

Amyloid-β protein (Aβ) Glu11 i ...... tes to Alzheimer pathogenesis.

@en

Amyloid-β protein (Aβ) Glu11 i ...... tes to Alzheimer pathogenesis.

@nl

prefLabel

Amyloid-β protein (Aβ) Glu11 i ...... tes to Alzheimer pathogenesis.

@en

Amyloid-β protein (Aβ) Glu11 i ...... tes to Alzheimer pathogenesis.

@nl

P1476

Amyloid-β protein (Aβ) Glu11 i ...... tes to Alzheimer pathogenesis.

@en

P2093

Fang Cai

http://www.w3.org/2001/XMLSchema#string

Ruitao Wang

http://www.w3.org/2001/XMLSchema#string

Shuting Zhang

http://www.w3.org/2001/XMLSchema#string

Xiaozhu Zhang

http://www.w3.org/2001/XMLSchema#string

Yu Deng

http://www.w3.org/2001/XMLSchema#string

Zhe Wang

http://www.w3.org/2001/XMLSchema#string

P2860

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity

Purification and cloning of amyloid precursor protein beta-secretase from human brain

A mutation in APP protects against Alzheimer’s disease and age-related cognitive decline

Neurotoxicity of Alzheimer's disease Aβ peptides is induced by small changes in the Aβ42 to Aβ40 ratio

Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

SIRT1 suppresses beta-amyloid production by activating the alpha-secretase gene ADAM10.

A pathogenic mutation for probable Alzheimer's disease in the APP gene at the N-terminus of beta-amyloid

Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease

Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice

P304

1962-1969

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scholarly article

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10.1111/EJN.12235

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English

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http://www.w3.org/2001/XMLSchema#string

P478

http://www.w3.org/2001/XMLSchema#string

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Weihong Song

Yili Wu

Matthias Staufenbiel

P577

2013-06-01T00:00:00Z

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P698

23773065

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Amyloid-β protein (Aβ) Glu11 is the major β-secretase site of β-site amyloid-β precursor protein-cleaving enzyme 1(BACE1), and shifting the cleavage site to Aβ Asp1 contributes to Alzheimer pathogenesis.

about

P2860

P2860

Amyloid-β protein (Aβ) Glu11 is the major β-secretase site of β-site amyloid-β precursor protein-cleaving enzyme 1(BACE1), and shifting the cleavage site to Aβ Asp1 contributes to Alzheimer pathogenesis.

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