Rational engineering of human cytochrome P450 2B6 for enhanced expression and stability: importance of a Leu264->Phe substitution.
about
Crystal structure of a cytochrome P450 2B6 genetic variant in complex with the inhibitor 4-(4-chlorophenyl)imidazole at 2.0-A resolutionLigand diversity of human and chimpanzee CYP3A4: activation of human CYP3A4 by lithocholic acid results from positive selectionStructures of Cytochrome P450 2B6 Bound to 4-Benzylpyridine and 4-(4-Nitrobenzyl)pyridine: Insight into Inhibitor Binding and Rearrangement of Active Site Side ChainsInvestigation by site-directed mutagenesis of the role of cytochrome P450 2B4 non-active-site residues in protein-ligand interactions based on crystal structures of the ligand-bound enzymeEngineering cytochrome P450 biocatalysts for biotechnology, medicine and bioremediationRational engineering of cytochromes P450 2B6 and 2B11 for enhanced stability: Insights into structural importance of residue 334Comparison of in vitro metabolism of ticlopidine by human cytochrome P450 2B6 and rabbit cytochrome P450 2B4Dynamics and flexibility of human aromatase probed by FTIR and time resolved fluorescence spectroscopySemirational Protein Engineering of CYP153AM.aq. -CPRBM3 for Efficient Terminal Hydroxylation of Short- to Long-Chain Fatty Acids.Plasticity of CYP2B enzymes: structural and solution biophysical methods.Functional characterization of cytochromes P450 2B from the desert woodrat Neotoma lepida.Cytochrome P450-Mediated Phytoremediation using Transgenic Plants: A Need for Engineered Cytochrome P450 Enzymes.Effect of alcohol on drug efflux protein and drug metabolic enzymes in U937 macrophagesFunctional importance of a peripheral pocket in mammalian cytochrome P450 2B enzymes.Identification and analysis of conserved sequence motifs in cytochrome P450 family 2. Functional and structural role of a motif 187RFDYKD192 in CYP2B enzymes.Analysis of Cytochrome P450 Conserved Sequence Motifs between Helices E and H: Prediction of Critical Motifs and Residues in Enzyme Functions.Decreased susceptibility of the cytochrome P450 2B6 variant K262R to inhibition by several clinically important drugs.
P2860
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P2860
Rational engineering of human cytochrome P450 2B6 for enhanced expression and stability: importance of a Leu264->Phe substitution.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年学术文章
@wuu
2007年学术文章
@zh
2007年学术文章
@zh-cn
2007年学术文章
@zh-hans
2007年学术文章
@zh-my
2007年学术文章
@zh-sg
2007年學術文章
@yue
2007年學術文章
@zh-hant
name
Rational engineering of human ...... of a Leu264->Phe substitution.
@en
Rational engineering of human ...... of a Leu264->Phe substitution.
@nl
type
label
Rational engineering of human ...... of a Leu264->Phe substitution.
@en
Rational engineering of human ...... of a Leu264->Phe substitution.
@nl
prefLabel
Rational engineering of human ...... of a Leu264->Phe substitution.
@en
Rational engineering of human ...... of a Leu264->Phe substitution.
@nl
P2093
P356
P1476
Rational engineering of human ...... of a Leu264->Phe substitution.
@en
P2093
B K Muralidhara
James R Halpert
Santosh Kumar
Surendra S Negi
Yonghong Zhao
P304
P356
10.1124/MOL.107.039693
P577
2007-08-22T00:00:00Z