Physical properties of human alpha 2-macroglobulin following reaction with methylamine and trypsin.
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Alpha-2-macroglobulin functions as an inhibitor of fibrinolytic, clotting, and neutrophilic proteinases in sepsis: studies using a baboon modelInflammatory mediators promote production of shed LRP1/CD91, which regulates cell signaling and cytokine expression by macrophagesA 16-amino acid peptide from human alpha2-macroglobulin binds transforming growth factor-beta and platelet-derived growth factor-BB.Distinct binding sites in the structure of alpha 2-macroglobulin mediate the interaction with beta-amyloid peptide and growth factors.Binding of transforming growth factor-beta 1 to methylamine-modified alpha 2-macroglobulin and to binary and ternary alpha 2-macroglobulin-proteinase complexesBeta-amyloid peptide binds equivalently to binary and ternary alpha2-macroglobulin-protease complexes.The structure of alpha 2-macroglobulin-methylamine after papain digestion as determined by electron microscopy.Binding of tumor necrosis factor alpha to activated forms of human plasma alpha 2 macroglobulinAn alpha 2-macroglobulin receptor-dependent mechanism for the plasma clearance of transforming growth factor-beta 1 in miceAlpha 2-macroglobulin functions as a cytokine carrier to induce nitric oxide synthesis and cause nitric oxide-dependent cytotoxicity in the RAW 264.7 macrophage cell line.Binding of platelet-derived growth factor-BB and transforming growth factor-beta 1 to alpha 2-macroglobulin in vitro and in vivo: comparison of receptor-recognized and non-recognized alpha 2-macroglobulin conformations.Differences in the binding of transforming growth factor beta 1 to the acute-phase reactant and constitutively synthesized alpha-macroglobulins of rat.Native and activated forms of alpha 2-macroglobulin increase expression of platelet-derived growth factor alpha-receptor in vascular smooth muscle cells. Evidence for autocrine transforming growth factor-beta activity.Activated alpha 2-macroglobulin promotes mitogenesis in rat vascular smooth muscle cells by a mechanism that is independent of growth-factor-carrier activity.Murine alpha-macroglobulins demonstrate divergent activities as neutralizers of transforming growth factor-beta and as inducers of nitric oxide synthesis. A possible mechanism for the endotoxin insensitivity of the alpha2-macroglobulin gene knock-ouProteinases are isoform-specific regulators of the binding of transforming growth factor beta to alpha 2-macroglobulin.Chemical modification of alpha2-macroglobulin to generate derivatives that bind transforming growth factor-beta with increased affinity.Localization of the binding site for transforming growth factor-beta in human alpha2-macroglobulin to a 20-kDa peptide that also contains the bait region.Conjugation of a brain-penetrant peptide with neurotensin provides antinociceptive propertiesStructure of native alpha 2-macroglobulin and its transformation to the protease bound formInsulin-regulated Glut4 translocation: membrane protein trafficking with six distinctive steps.Low resolution X-ray structure of human methylamine-treated alpha 2-macroglobulin.Effect of methylamine and plasmin on the conformation of human alpha 2-macroglobulin as revealed by differential scanning calorimetric analysisKinetic evidence that Glut4 follows different endocytic pathways than the receptors for transferrin and alpha2-macroglobulin.Alpha-2-macroglobulin as the major defence in acute pseudomonal septic shock in the guinea-pig modelThe NMDA receptor functions independently and as an LRP1 co-receptor to promote Schwann cell survival and migration.The human alpha 2-macroglobulin receptor: identification of a 420-kD cell surface glycoprotein specific for the activated conformation of alpha 2-macroglobulin.Regulation of cytokine expression by Schwann cells in response to α2-macroglobulin binding to LRP1.Molecular cloning of Limulus alpha 2-macroglobulin.LRP1 assembles unique co-receptor systems to initiate cell signaling in response to tissue-type plasminogen activator and myelin-associated glycoprotein.Altered interaction of Cis-dichlorodiammineplatinum(II)--modified alpha 2-macroglobulin (alpha 2M) with the low density lipoprotein receptor-related protein/alpha 2M receptor but not the alpha 2M signaling receptor.Model of alpha 2-macroglobulin structure and function.Novel complex formed between a nonproteolytic cell wall protein of group A streptococci and alpha 2-macroglobulin.Molecular dissection of the human alpha2-macroglobulin subunit reveals domains with antagonistic activities in cell signaling.The proteinase-binding reaction of alpha 2M.Electron microscopy of the conformational changes of alpha 2-macroglobulin from human plasmaLigand binding to LRP1 transactivates Trk receptors by a Src family kinase-dependent pathway.Alpha 2-macroglobulin bait region variants. A role for the bait region in tetramer formation.The structure around the thioester bond in bovine alpha 2-macroglobulin. Possible implications for the conformational stability of the inhibitor on thioester cleavage.Role of the scavenger receptor in the uptake of methylamine-activated alpha 2-macroglobulin by rat liver.
P2860
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P2860
Physical properties of human alpha 2-macroglobulin following reaction with methylamine and trypsin.
description
1982 nî lūn-bûn
@nan
1982 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
1982年の論文
@ja
1982年学术文章
@wuu
1982年学术文章
@zh
1982年学术文章
@zh-cn
1982年学术文章
@zh-hans
1982年学术文章
@zh-my
1982年学术文章
@zh-sg
1982年學術文章
@yue
name
Physical properties of human a ...... with methylamine and trypsin.
@en
Physical properties of human a ...... with methylamine and trypsin.
@nl
type
label
Physical properties of human a ...... with methylamine and trypsin.
@en
Physical properties of human a ...... with methylamine and trypsin.
@nl
prefLabel
Physical properties of human a ...... with methylamine and trypsin.
@en
Physical properties of human a ...... with methylamine and trypsin.
@nl
P2093
P1476
Physical properties of human a ...... with methylamine and trypsin.
@en
P2093
J A Reynolds
S L Gonias
P304
P356
10.1016/0167-4838(82)90252-7
P577
1982-08-01T00:00:00Z