Enforced expression of GATA-3 during T cell development inhibits maturation of CD8 single-positive cells and induces thymic lymphoma in transgenic mice.
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GATA3 and the T-cell lineage: essential functions before and after T-helper-2-cell differentiationEnforced expression of GATA3 allows differentiation of IL-17-producing cells, but constrains Th17-mediated pathologyMast cell lineage diversion of T lineage precursors by the essential T cell transcription factor GATA-3Distinct functions for the transcription factors GATA-3 and ThPOK during intrathymic differentiation of CD4(+) T cellsRegulation of GATA-3 expression during CD4 lineage differentiation.GATA3 controls the expression of CD5 and the T cell receptor during CD4 T cell lineage developmentItk derived signals regulate the expression of Th-POK and controls the development of CD4 T cells.Transcriptomic analysis supports similar functional roles for the two thymuses of the tammar wallaby.From the cradle to the grave: activities of GATA-3 throughout T-cell development and differentiation.Mutation of GATA3 in human breast tumors.E proteins and the regulation of early lymphocyte developmentLineage fate and intense debate: myths, models and mechanisms of CD4- versus CD8-lineage choice.GATA Transcription Factors and Cancer.DNA methylation of Th2 lineage determination genes at birth is associated with allergic outcomes in childhood.An NK and T cell enhancer lies 280 kilobase pairs 3' to the gata3 structural gene.CD4/CD8-lineage differentiation in the thymus: from nuclear effectors to membrane signals.Transactivation of human osteoprotegerin promoter by GATA-3CD4-CD8 lineage differentiation: Thpok-ing into the nucleus.A monoallelic-to-biallelic T-cell transcriptional switch regulates GATA3 abundance.CD4-CD8 lineage commitment: an inside view.Role of the transcription factor Th-POK in CD4:CD8 lineage commitment.Centromeric repositioning of coreceptor loci predicts their stable silencing and the CD4/CD8 lineage choice.Lineage-affiliated transcription factors bind the Gata3 Tce1 enhancer to mediate lineage-specific programs.E2A transcription factors limit expression of Gata3 to facilitate T lymphocyte lineage commitment.Essential, dose-dependent role for the transcription factor Gata3 in the development of IL-5+ and IL-13+ type 2 innate lymphoid cellsCompetition and collaboration: GATA-3, PU.1, and Notch signaling in early T-cell fate determination.PU.1 regulates TCR expression by modulating GATA-3 activity.Gata3 restrains B cell proliferation and cooperates with p18INK4c to repress B cell lymphomagenesis.Interleukin-13 gene expression is regulated by GATA-3 in T cells: role of a critical association of a GATA and two GATG motifs.Hematopoiesis and T-cell specification as a model developmental system.GATA3 Abundance Is a Critical Determinant of T Cell Receptor β Allelic Exclusion.Fbw7 targets GATA3 through cyclin-dependent kinase 2-dependent proteolysis and contributes to regulation of T-cell development.Regulation of GATA-binding protein 2 levels via ubiquitin-dependent degradation by Fbw7: involvement of cyclin B-cyclin-dependent kinase 1-mediated phosphorylation of THR176 in GATA-binding protein 2.c-Myb regulates lineage choice in developing thymocytes via its target gene Gata3.Involvement of GATA-3-dependent Th2 lymphocyte activation in airway hyperresponsiveness.Switching sides: transcriptional control of CD4 thymocyte lineage commitment.Transcriptional regulation of GATA3 in T helper cells by the integrated activities of transcription factors downstream of the interleukin-4 receptor and T cell receptor.Decision by committee: new light on the CD4/CD8-lineage choice
P2860
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P2860
Enforced expression of GATA-3 during T cell development inhibits maturation of CD8 single-positive cells and induces thymic lymphoma in transgenic mice.
description
2001 nî lūn-bûn
@nan
2001年の論文
@ja
2001年学术文章
@wuu
2001年学术文章
@zh
2001年学术文章
@zh-cn
2001年学术文章
@zh-hans
2001年学术文章
@zh-my
2001年学术文章
@zh-sg
2001年學術文章
@yue
2001年學術文章
@zh-hant
name
Enforced expression of GATA-3 ...... c lymphoma in transgenic mice.
@en
Enforced expression of GATA-3 ...... c lymphoma in transgenic mice.
@nl
type
label
Enforced expression of GATA-3 ...... c lymphoma in transgenic mice.
@en
Enforced expression of GATA-3 ...... c lymphoma in transgenic mice.
@nl
prefLabel
Enforced expression of GATA-3 ...... c lymphoma in transgenic mice.
@en
Enforced expression of GATA-3 ...... c lymphoma in transgenic mice.
@nl
P2093
P1476
Enforced expression of GATA-3 ...... ic lymphoma in transgenic mice
@en
P2093
F Grosveld
G M Dingjan
M C Nawijn
R W Hendriks
P304
P356
10.4049/JIMMUNOL.167.2.715
P407
P577
2001-07-01T00:00:00Z