Comprehensive Translational Assessment of Human-Induced Pluripotent Stem Cell Derived Cardiomyocytes for Evaluating Drug-Induced Arrhythmias.
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In vitro cardiotoxicity assessment of environmental chemicals using an organotypic human induced pluripotent stem cell-derived model.Electrophysiological Analysis of human Pluripotent Stem Cell-derived Cardiomyocytes (hPSC-CMs) Using Multi-electrode Arrays (MEAs)Human iPSC-derived cardiomyocytes and tissue engineering strategies for disease modeling and drug screening.Frequency-dependent drug screening using optogenetic stimulation of human iPSC-derived cardiomyocytes.Humans Vary, So Cardiac Models Should Account for That Too!hiPSC-CM Monolayer Maturation State Determines Drug Responsiveness in High Throughput Pro-Arrhythmia ScreenMechanistic Model-Informed Proarrhythmic Risk Assessment of Drugs: Review of the "CiPA" Initiative and Design of a Prospective Clinical Validation Study.Nonclinical cardiovascular safety of pitolisant: comparing International Conference on Harmonization S7B and Comprehensive in vitro Pro-arrhythmia Assay initiative studies.Drug-Mediated Shortening of Action Potentials in LQTS2 Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes.Adult Human Primary Cardiomyocyte-Based Model for the Simultaneous Prediction of Drug-Induced Inotropic and Pro-arrhythmia Risk.Tailoring Mathematical Models to Stem-Cell Derived Cardiomyocyte Lines Can Improve Predictions of Drug-Induced Changes to Their Electrophysiology.Composite Biomarkers Derived from Micro-Electrode Array Measurements and Computer Simulations Improve the Classification of Drug-Induced Channel Block.An evaluation of multiple algorithms for the measurement of the heart rate corrected JTpeak interval.A Hybrid Model for Safety Pharmacology on an Automated Patch Clamp Platform: Using Dynamic Clamp to Join iPSC-Derived Cardiomyocytes and Simulations of Ik1 Ion Channels in Real-Time.Action Potential Recording and Pro-arrhythmia Risk Analysis in Human Ventricular Trabeculae.Blinded Contractility Analysis in hiPSC-Cardiomyocytes in Engineered Heart Tissue Format: Comparison With Human Atrial Trabeculae.Translating New Science Into the Drug Review Process: The US FDA's Division of Applied Regulatory Science.Population-based mechanistic modeling allows for quantitative predictions of drug responses across cell types.Cross-Site Reliability of Human Induced Pluripotent Stem-Cell Derived Cardiomyocyte Based Safety Assays using Microelectrode Arrays: Results from a Blinded CiPA Pilot Study.Toxicological evaluation of convulsant and anticonvulsant drugs in human induced pluripotent stem cell-derived cortical neuronal networks using an MEA system.International Multisite Study of Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes for Drug Proarrhythmic Potential AssessmentOn-chip spatiotemporal electrophysiological analysis of human stem cell derived cardiomyocytes enables quantitative assessment of proarrhythmia in drug development
P2860
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P2860
Comprehensive Translational Assessment of Human-Induced Pluripotent Stem Cell Derived Cardiomyocytes for Evaluating Drug-Induced Arrhythmias.
description
2016 nî lūn-bûn
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2016年の論文
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2016年学术文章
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2016年学术文章
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2016年学术文章
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@zh-hans
2016年学术文章
@zh-my
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name
Comprehensive Translational As ...... ting Drug-Induced Arrhythmias.
@en
Comprehensive Translational As ...... ting Drug-Induced Arrhythmias.
@nl
type
label
Comprehensive Translational As ...... ting Drug-Induced Arrhythmias.
@en
Comprehensive Translational As ...... ting Drug-Induced Arrhythmias.
@nl
prefLabel
Comprehensive Translational As ...... ting Drug-Induced Arrhythmias.
@en
Comprehensive Translational As ...... ting Drug-Induced Arrhythmias.
@nl
P2093
P2860
P50
P356
P1476
Comprehensive Translational As ...... ting Drug-Induced Arrhythmias.
@en
P2093
Beverly Lyn-Cook
Daniel Millard
David G Strauss
Dulciana Chan
Godfrey Smith
James Ross
Jayna Stohlman
Lars Johannesen
Loriano Galeotti
P2860
P304
P356
10.1093/TOXSCI/KFW200
P577
2016-10-03T00:00:00Z