Ligand-Dependent Modulation of G Protein Conformation Alters Drug Efficacy.
about
Dianthin-30 or gelonin versus monomethyl auristatin E, each configured with an anti-calcitonin receptor antibody, are differentially potent in vitro in high-grade glioma cell lines derived from glioblastoma.Allosteric Modulation of GPCRs: New Insights and Potential Utility for Treatment of Schizophrenia and Other CNS Disorders.Translating in vitro ligand bias into in vivo efficacy.The Diverse Roles of Arrestin Scaffolds in G Protein-Coupled Receptor Signaling.Agonist-induced dimer dissociation as a macromolecular step in G protein-coupled receptor signaling.Phase-plate cryo-EM structure of a class B GPCR-G-protein complex.Systematic errors in detecting biased agonism: Analysis of current methods and development of a new model-free approach.Update on the pharmacology of calcitonin/CGRP family of peptides: IUPHAR Review 25.Biased signalling: from simple switches to allosteric microprocessors.On the G protein-coupling selectivity of the native A2B adenosine receptor.EGFR Ligands Differentially Stabilize Receptor Dimers to Specify Signaling Kinetics.A kinetic view of GPCR allostery and biased agonism.Extracellular loops 2 and 3 of the calcitonin receptor selectively modify agonist binding and efficacy.Structure and dynamics of GPCR signaling complexes.Coding GPCR-G protein specificity.Selectivity determinants of GPCR-G-protein binding.What determines the magnitude of cellular response for activation of G protein-coupled receptors?GHSR-D2R heteromerization modulates dopamine signaling through an effect on G protein conformation.
P2860
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P2860
Ligand-Dependent Modulation of G Protein Conformation Alters Drug Efficacy.
description
2016 nî lūn-bûn
@nan
2016年の論文
@ja
2016年学术文章
@wuu
2016年学术文章
@zh
2016年学术文章
@zh-cn
2016年学术文章
@zh-hans
2016年学术文章
@zh-my
2016年学术文章
@zh-sg
2016年學術文章
@yue
2016年學術文章
@zh-hant
name
Ligand-Dependent Modulation of G Protein Conformation Alters Drug Efficacy.
@en
Ligand-Dependent Modulation of G Protein Conformation Alters Drug Efficacy.
@nl
type
label
Ligand-Dependent Modulation of G Protein Conformation Alters Drug Efficacy.
@en
Ligand-Dependent Modulation of G Protein Conformation Alters Drug Efficacy.
@nl
prefLabel
Ligand-Dependent Modulation of G Protein Conformation Alters Drug Efficacy.
@en
Ligand-Dependent Modulation of G Protein Conformation Alters Drug Efficacy.
@nl
P2093
P50
P1433
P1476
Ligand-Dependent Modulation of G Protein Conformation Alters Drug Efficacy.
@en
P2093
Asuka Inoue
Emma Dal Maso
Michelle Louise Halls
Yi-Lynn Liang
P304
739-749.e11
P356
10.1016/J.CELL.2016.09.021
P407
P50
P577
2016-10-06T00:00:00Z