GNA11 Q209L Mouse Model Reveals RasGRP3 as an Essential Signaling Node in Uveal Melanoma.

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GNA14 silencing suppresses the proliferation of endometrial carcinoma cells through inducing apoptosis and G/M cell cycle arrest

P2860

Q58760393-E1874A98-949F-4D8D-9C08-5A6E0D8A9A4E

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GNA11 Q209L Mouse Model Reveals RasGRP3 as an Essential Signaling Node in Uveal Melanoma.

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http://www.wikidata.org/entity/Q51418687

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2018 nî lūn-bûn

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2018年学术文章

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GNA11 Q209L Mouse Model Reveals RasGRP3 as an Essential Signaling Node in Uveal Melanoma.

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GNA11 Q209L Mouse Model Reveals RasGRP3 as an Essential Signaling Node in Uveal Melanoma.

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GNA11 Q209L Mouse Model Reveals RasGRP3 as an Essential Signaling Node in Uveal Melanoma.

@en

GNA11 Q209L Mouse Model Reveals RasGRP3 as an Essential Signaling Node in Uveal Melanoma.

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GNA11 Q209L Mouse Model Reveals RasGRP3 as an Essential Signaling Node in Uveal Melanoma.

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GNA11 Q209L Mouse Model Reveals RasGRP3 as an Essential Signaling Node in Uveal Melanoma.

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P1476

GNA11 Q209L Mouse Model Reveals RasGRP3 as an Essential Signaling Node in Uveal Melanoma.

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P2093

Alexander N Shoushtari

http://www.w3.org/2001/XMLSchema#string

Amanda R Moore

http://www.w3.org/2001/XMLSchema#string

Catalina Hwang

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Edward G Walzak

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Jenny Q Zhang

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Jessica J Sher

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Klaus G Griewank

http://www.w3.org/2001/XMLSchema#string

Leili Ran

http://www.w3.org/2001/XMLSchema#string

Ping Chi

http://www.w3.org/2001/XMLSchema#string

Rajmohan Murali

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P2860

Identification of guanine nucleotide exchange factors (GEFs) for the Rap1 GTPase. Regulation of MR-GEF by M-Ras-GTP interaction

Disruption of CRAF-mediated MEK activation is required for effective MEK inhibition in KRAS mutant tumors

Mutant Gq/11 promote uveal melanoma tumorigenesis by activating YAP

Activation of RasGRP3 by phosphorylation of Thr-133 is required for B cell receptor-mediated Ras activation

Frequent mutation of BAP1 in metastasizing uveal melanomas

Mutations in GNA11 in uveal melanoma

Frequent somatic mutations of GNAQ in uveal melanoma and blue naevi

Crystal structure of ARF1*Sec7 complexed with Brefeldin A and its implications for the guanine nucleotide exchange mechanism

Safety, pharmacokinetic, pharmacodynamic, and efficacy data for the oral MEK inhibitor trametinib: a phase 1 dose-escalation trial.

Effect of selumetinib vs chemotherapy on progression-free survival in uveal melanoma: a randomized clinical trial.

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2455-2468

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scholarly article

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10.1016/J.CELREP.2018.01.081

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P433

http://www.w3.org/2001/XMLSchema#string

P478

http://www.w3.org/2001/XMLSchema#string

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2018-02-01T00:00:00Z

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29490280

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P932

5854482

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GNA11 Q209L Mouse Model Reveals RasGRP3 as an Essential Signaling Node in Uveal Melanoma.

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P2860

GNA11 Q209L Mouse Model Reveals RasGRP3 as an Essential Signaling Node in Uveal Melanoma.

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P1476

P2093

P2860

P304

P31

P356

P433

P478

P577

P698

P932

P356

P1433

P1476

P2093

P2860

P304

P31

P356

P433

P478

P577

P698

P932