Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, part 1: oral solutions.
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Predicting Drug Extraction in the Human Gut Wall: Assessing Contributions from Drug Metabolizing Enzymes and Transporter Proteins using Preclinical ModelsTranslating Human Effective Jejunal Intestinal Permeability to Surface-Dependent Intrinsic Permeability: a Pragmatic Method for a More Mechanistic Prediction of Regional Oral Drug Absorption.In vivo imaging of systemic transport and elimination of xenobiotics and endogenous molecules in mice.A physiologically based pharmacokinetic model of the minipig: data compilation and model implementation.Association between Genetic Polymorphisms in DEFB1 and Susceptibility to Digestive Diseases.Evaluation of changes in oral drug absorption in preterm and term neonates for Biopharmaceutics Classification System (BCS) class I and II compounds.Development of a paediatric population-based model of the pharmacokinetics of rivaroxaban.Physiologically based pharmacokinetic modelling and in vivo [I]/K(i) accurately predict P-glycoprotein-mediated drug-drug interactions with dabigatran etexilate.Coupling biorelevant dissolution methods with physiologically based pharmacokinetic modelling to forecast in-vivo performance of solid oral dosage forms.Physiologically based pharmacokinetic modeling in drug discovery and development: a pharmaceutical industry perspective.The Application of Physiologically Based Pharmacokinetic Modeling to Predict the Role of Drug Transporters: Scientific and Regulatory Perspectives.Integration of dissolution into physiologically-based pharmacokinetic models III: PK-Sim®.Dosage and Dose Schedule Screening of Drug Combinations in Agent-Based Models Reveals Hidden Synergies.Applied Concepts in PBPK Modeling: How to Build a PBPK/PD Model.A Generic Integrated Physiologically based Whole-body Model of the Glucose-Insulin-Glucagon Regulatory System.A generic whole body physiologically based pharmacokinetic model for therapeutic proteins in PK-Sim.The feasibility of physiologically based pharmacokinetic modeling in forensic medicine illustrated by the example of morphine.A physiologically based pharmacokinetic and pharmacodynamic (PBPK/PD) model of the histone deacetylase (HDAC) inhibitor vorinostat for pediatric and adult patients and its application for dose specification.A Physiologically Based Pharmacokinetic Model for Pregnant Women to Predict the Pharmacokinetics of Drugs Metabolized Via Several Enzymatic Pathways.Monitoring of erlotinib in pancreatic cancer patients during long-time administration and comparison to a physiologically based pharmacokinetic model.Development and validation of a physiology-based model for the prediction of pharmacokinetics/toxicokinetics in rabbits.Use of QSPR Modeling to Characterize In Vitro Binding of Drugs to a Gut-Restricted Polymer.Physiologically based pharmacokinetic modelling of atomoxetine with regard to CYP2D6 genotypes
P2860
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P2860
Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, part 1: oral solutions.
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2011 nî lūn-bûn
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2011年の論文
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2011年学术文章
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2011年学术文章
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2011年学术文章
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2011年学术文章
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2011年学术文章
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2011年學術文章
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name
Evolution of a detailed physio ...... umans, part 1: oral solutions.
@en
Evolution of a detailed physio ...... umans, part 1: oral solutions.
@nl
type
label
Evolution of a detailed physio ...... umans, part 1: oral solutions.
@en
Evolution of a detailed physio ...... umans, part 1: oral solutions.
@nl
prefLabel
Evolution of a detailed physio ...... umans, part 1: oral solutions.
@en
Evolution of a detailed physio ...... umans, part 1: oral solutions.
@nl
P2093
P356
P1476
Evolution of a detailed physio ...... umans, part 1: oral solutions.
@en
P2093
Jennifer B Dressman
Jörg Lippert
Katrin Coboeken
Kirstin Thelen
Rolf Burghaus
Stefan Willmann
P304
P356
10.1002/JPS.22726
P407
P577
2011-10-12T00:00:00Z