DNA replication timing and selection shape the landscape of nucleotide variation in cancer genomes.
about
Complex correlations: replication timing and mutational landscapes during cancer and genome evolutionAcute myeloid leukaemia: a paradigm for the clonal evolution of cancer?De novo identification of replication-timing domains in the human genome by deep learningCancer evolution is associated with pervasive positive selection on globally expressed genesInvestigating core genetic-and-epigenetic cell cycle networks for stemness and carcinogenic mechanisms, and cancer drug design using big database mining and genome-wide next-generation sequencing dataThe mutation spectrum in genomic late replication domains shapes mammalian GC contentDifferential relationship of DNA replication timing to different forms of human mutation and variation.Heterogeneous polymerase fidelity and mismatch repair bias genome variation and composition.MSEA: detection and quantification of mutation hotspots through mutation set enrichment analysisGenome architecture and its roles in human copy number variation.Analysis of micro-rearrangements in 25 eukaryotic species pairs by SyntenyMapperCell-of-origin chromatin organization shapes the mutational landscape of cancerMADGiC: a model-based approach for identifying driver genes in cancerSignatures of accelerated somatic evolution in gene promoters in multiple cancer types.Extremely high genetic diversity in a single tumor points to prevalence of non-Darwinian cell evolution.A Dual Model for Prioritizing Cancer Mutations in the Non-coding Genome Based on Germline and Somatic EventsPredicting the recurrence of noncoding regulatory mutations in cancerGenome-wide Determination of Mammalian Replication Timing by DNA Content Measurement.Genomic approaches to DNA repair and mutagenesis.APOBEC-induced mutations in human cancers are strongly enriched on the lagging DNA strand during replication.Mutation pattern is an influential factor on functional mutation rates in cancer.Mammalian RAD51 paralogs protect nascent DNA at stalled forks and mediate replication restart.DNA replication timing, genome stability and cancer: late and/or delayed DNA replication timing is associated with increased genomic instability.Loss of heterozygosity preferentially occurs in early replicating regions in cancer genomes.The topography of mutational processes in breast cancer genomes.Are sites with multiple single nucleotide variants in cancer genomes a consequence of drivers, hypermutable sites or sequencing errors?Direct measurements of human colon crypt stem cell niche genetic fidelity: the role of chance in non-darwinian mutation selection.Stability of patient-specific features of altered DNA replication timing in xenografts of primary human acute lymphoblastic leukemia.From Mutational Mechanisms in Single Cells to Mutational Patterns in Cancer Genomes.Analysis of a transgenic Oct4 enhancer reveals high fidelity long-range chromosomal interactions.Differential DNA mismatch repair underlies mutation rate variation across the human genome.UV-Induced DNA Damage and Mutagenesis in Chromatin.Evolution of Local Mutation Rate and Its Determinants.Perturbations in the Replication Program Contribute to Genomic Instability in Cancer.DNA replication timing and higher-order nuclear organization determine single-nucleotide substitution patterns in cancer genomes.Rates, distribution and implications of postzygotic mosaic mutations in autism spectrum disorder.Polymerase ζ Activity Is Linked to Replication Timing in Humans: Evidence from Mutational Signatures.Whole-genome mutational landscape and characterization of noncoding and structural mutations in liver cancer.Mutation-profile-based methods for understanding selection forces in cancer somatic mutations: a comparative analysis.Whole-genome mutational analysis: cause and effect of noncoding and structural mutations in liver cancer.
P2860
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P2860
DNA replication timing and selection shape the landscape of nucleotide variation in cancer genomes.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年学术文章
@wuu
2012年学术文章
@zh
2012年学术文章
@zh-cn
2012年学术文章
@zh-hans
2012年学术文章
@zh-my
2012年学术文章
@zh-sg
2012年學術文章
@yue
2012年學術文章
@zh-hant
name
DNA replication timing and sel ...... e variation in cancer genomes.
@en
DNA replication timing and sel ...... e variation in cancer genomes.
@nl
type
label
DNA replication timing and sel ...... e variation in cancer genomes.
@en
DNA replication timing and sel ...... e variation in cancer genomes.
@nl
prefLabel
DNA replication timing and sel ...... e variation in cancer genomes.
@en
DNA replication timing and sel ...... e variation in cancer genomes.
@nl
P356
P1476
DNA replication timing and sel ...... e variation in cancer genomes.
@en
P2093
Yong H Woo
P2888
P356
10.1038/NCOMMS1982
P407
P577
2012-01-01T00:00:00Z