Alzheimer's disease-associated TREM2 variants exhibit either decreased or increased ligand-dependent activation.
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Effect of high fat diet on phenotype, brain transcriptome and lipidome in Alzheimer's model miceTREM2 in Neurodegenerative Diseases.TREM2-Ligand Interactions in Health and Disease.A split-luciferase complementation, real-time reporting assay enables monitoring of the disease-associated transmembrane protein TREM2 in live cells.An Alzheimer-associated TREM2 variant occurs at the ADAM cleavage site and affects shedding and phagocytic function.TREM2 deficiency attenuates neuroinflammation and protects against neurodegeneration in a mouse model of tauopathy.Humanized TREM2 mice reveal microglia-intrinsic and -extrinsic effects of R47H polymorphism.Alzheimer's disease hypothesis and related therapies.ApoE facilitates the microglial response to amyloid plaque pathology.TREM2-activating antibodies abrogate the negative pleiotropic effects of the Alzheimer's disease variant TREM2R47H on murine myeloid cell function.Alzheimer's Disease, Oligomers, and Inflammation.TREM2 regulates innate immunity in Alzheimer's disease.The Trem2 R47H variant confers loss-of-function-like phenotypes in Alzheimer's disease.Microglia in Alzheimer's diseaseMicroglia in Alzheimer's Disease: A Role for Ion ChannelsCellular Receptors of Amyloid β Oligomers (AβOs) in Alzheimer's DiseaseHigh-affinity interactions and signal transduction between Aβ oligomers and TREM2
P2860
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P2860
Alzheimer's disease-associated TREM2 variants exhibit either decreased or increased ligand-dependent activation.
description
2016 nî lūn-bûn
@nan
2016年の論文
@ja
2016年学术文章
@wuu
2016年学术文章
@zh
2016年学术文章
@zh-cn
2016年学术文章
@zh-hans
2016年学术文章
@zh-my
2016年学术文章
@zh-sg
2016年學術文章
@yue
2016年學術文章
@zh-hant
name
Alzheimer's disease-associated ...... d ligand-dependent activation.
@en
Alzheimer's disease-associated ...... d ligand-dependent activation.
@nl
type
label
Alzheimer's disease-associated ...... d ligand-dependent activation.
@en
Alzheimer's disease-associated ...... d ligand-dependent activation.
@nl
prefLabel
Alzheimer's disease-associated ...... d ligand-dependent activation.
@en
Alzheimer's disease-associated ...... d ligand-dependent activation.
@nl
P2093
P2860
P50
P1476
Alzheimer's disease-associated ...... ed ligand-dependent activation
@en
P2093
Basavaraj Hooli
Kristina Mullin
Marco Colonna
Rudolph E Tanzi
Wilbur Song
Yaming Wang
P2860
P304
P356
10.1016/J.JALZ.2016.07.004
P577
2016-08-09T00:00:00Z