about
Generation of 'Unnatural Natural Product' library and identification of a small molecule inhibitor of XIAP.A simple analogue of tumor-promoting aplysiatoxin is an antineoplastic agent rather than a tumor promoter: development of a synthetically accessible protein kinase C activator with bryostatin-like activity.Three genomes differentially contribute to the biosynthesis of benzoxazinones in hexaploid wheat.Challenges to the development of bryostatin-type anticancer drugs based on the activation mechanism of protein kinase Cδ.Synthesis and biological activities of simplified analogs of the natural PKC ligands, bryostatin-1 and aplysiatoxin.Loss of the Phenolic Hydroxyl Group and Aromaticity from the Side Chain of Anti-Proliferative 10-Methyl-aplog-1, a Simplified Analog of Aplysiatoxin, Enhances Its Tumor-Promoting and Proinflammatory Activities.Effects of the methoxy group in the side chain of debromoaplysiatoxin on its tumor-promoting and anti-proliferative activities.Structure-activity studies on the side chain of a simplified analog of aplysiatoxin (aplog-1) with anti-proliferative activity.Structure-activity studies on the spiroketal moiety of a simplified analogue of debromoaplysiatoxin with antiproliferative activity.Indolactam-V is involved in the CH/pi interaction with Pro-11 of the PKCdelta C1B domain: application for the structural optimization of the PKCdelta ligand.Binding mode prediction of aplysiatoxin, a potent agonist of protein kinase C, through molecular simulation and structure-activity study on simplified analogs of the receptor-recognition domain.Design and synthesis of 8-octyl-benzolactam-V9, a selective activator for protein kinase C epsilon and eta.Identification and biological activities of bryostatins from Japanese bryozoan.Practical Enantioselective Reduction of Ketones Using Oxazaborolidine Catalysts Generated In Situ from Chiral Lactam AlcoholsSynthesis, conformational analysis, and biological evaluation of 1-hexylindolactam-V10 as a selective activator for novel protein kinase C isozymesControl of the toxic conformation of amyloid β42 by intramolecular disulfide bond formation
P50
Q33940310-8ECE7142-88FD-4CDD-B58E-6DB63475E1C6Q34017564-27D9713F-937E-451F-B08F-C90164912FBBQ34132228-71F23AD4-9059-4C6D-87CD-C0DF014BB76CQ38005950-6B4960D7-F668-4A2B-8B86-04B16992CB98Q38200047-B4695FDE-8514-4C75-A13C-DD72569B7AC4Q38707861-7F0247B9-7E65-4DE5-9068-20F412AF1CCCQ39134610-F105D2C0-AC74-47E6-9AA4-4DE6F1753F8EQ39167301-9B241071-6E6E-4BAD-B497-0BE418F6B7DAQ39342875-2B8907C4-63F1-4280-A3C4-2DC88105B9D2Q46444925-60F37CF9-E86D-4EE6-9EDA-6C54668DBD16Q51629634-E5B03D0A-E60C-498D-8AFD-DB5842EB2682Q53625727-28FB7222-44E9-453C-BB64-EAA6F91703E1Q54501411-79921E07-0D83-4B78-91E3-5585FC59E603Q58693063-37E90124-766C-4F95-8A84-953780B671CFQ80179298-82E230DE-C863-40EA-B006-1B72A5ABAEDBQ90259856-222D6383-CD4D-475A-AE6C-4CEE33ABE3A2
P50
description
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Ryo C Yanagita
@nl
Ryo C Yanagita
@sl
Ryo C. Yanagita
@en
Ryo C. Yanagita
@es
type
label
Ryo C Yanagita
@nl
Ryo C Yanagita
@sl
Ryo C. Yanagita
@en
Ryo C. Yanagita
@es
altLabel
柳田亮
@en
prefLabel
Ryo C Yanagita
@nl
Ryo C Yanagita
@sl
Ryo C. Yanagita
@en
Ryo C. Yanagita
@es
P106
P1153
9435255400
P31
P496
0000-0002-9217-5507