Cell-based proteome profiling of potential dasatinib targets by use of affinity-based probes.
about
A quantitative chemical proteomics approach to profile the specific cellular targets of andrographolide, a promising anticancer agent that suppresses tumor metastasisCellular senescence in aging and age-related disease: from mechanisms to therapyAffinity-Based Probes Based on Type II Kinase InhibitorsActive site profiling reveals coupling between domains in SRC-family kinasesDevelopment and Applications of the Copper-Catalyzed Azide-Alkyne Cycloaddition (CuAAC) as a Bioorthogonal ReactionIn situ imaging and proteome profiling indicate andrographolide is a highly promiscuous compound.Ugi reaction-assisted rapid assembly of affinity-based probes against potential protein tyrosine phosphatases.Active/inactive dual-probe system for selective photoaffinity labeling of small molecule-binding proteins.Parasite-based screening and proteome profiling reveal orlistat, an FDA-approved drug, as a potential anti Trypanosoma brucei agent.Chemistry-based functional proteomics for drug target deconvolution.B-cell receptor signaling as a driver of lymphoma development and evolution.Target deconvolution techniques in modern phenotypic profiling.Selective fluorescence detection of small-molecule-binding proteins by using a dual photoaffinity labeling system.Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling.Multiplex imaging and cellular target identification of kinase inhibitors via an affinity-based proteome profiling approach.Improved angiostatic activity of dasatinib by modulation with hydrophobic chainsGrowth factor dependent regulation of centrosome function and genomic instability by HuR.Photoaffinity labeling in target- and binding-site identificationCell permeable affinity- and activity-based probes.Cell-permeable probe for identification and imaging of sialidasesA peptide photoaffinity probe specific for the active conformation of the Abl tyrosine kinase.Advances in the proteomic discovery of novel therapeutic targets in cancer.Problems and Solutions in Click Chemistry Applied to Drug Probes.Bioorthogonal approach to identify unsuspected drug targets in live cells.Doxycycline directly targets PAR1 to suppress tumor progression.From noncovalent to covalent bonds: a paradigm shift in target protein identification.Small-molecule probes elucidate global enzyme activity in a proteomic context.Proteomics in mechanistic toxicology: history, concepts, achievements, caveats, and potential.Activity-based protein profiling: recent advances in probe development and applications.Affinity purification in target identification: the specificity challenge.Target identification of natural products and bioactive compounds using affinity-based probes.Design, Synthesis, and Evaluation of Dasatinib-Amino Acid and Dasatinib-Fatty Acid Conjugates as Protein Tyrosine Kinase Inhibitors.A general approach for the development of fluorogenic probes suitable for no-wash imaging of kinases in live cells.Live cell off-target identification of lapatinib using ligand-directed tosyl chemistry.Broad-Spectrum Kinase Profiling in Live Cells with Lysine-Targeted Sulfonyl Fluoride Probes.Cell-based proteome profiling using an affinity-based probe (AfBP) derived from 3-deazaneplanocin A (DzNep).Chalcone: A Privileged Structure in Medicinal Chemistry.Design, synthesis and biological evaluation of photoaffinity probes of antiangiogenic homoisoflavonoids.Photo-affinity labelling and biochemical analyses identify the target of trypanocidal simplified natural product analogues.Design, synthesis and biological evaluation of potent azadipeptide nitrile inhibitors and activity-based probes as promising anti-Trypanosoma brucei agents.
P2860
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P2860
Cell-based proteome profiling of potential dasatinib targets by use of affinity-based probes.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年学术文章
@wuu
2012年学术文章
@zh
2012年学术文章
@zh-cn
2012年学术文章
@zh-hans
2012年学术文章
@zh-my
2012年学术文章
@zh-sg
2012年學術文章
@yue
2012年學術文章
@zh-hant
name
Cell-based proteome profiling ...... use of affinity-based probes.
@en
Cell-based proteome profiling ...... use of affinity-based probes.
@nl
type
label
Cell-based proteome profiling ...... use of affinity-based probes.
@en
Cell-based proteome profiling ...... use of affinity-based probes.
@nl
prefLabel
Cell-based proteome profiling ...... use of affinity-based probes.
@en
Cell-based proteome profiling ...... use of affinity-based probes.
@nl
P2093
P356
P1476
Cell-based proteome profiling ...... use of affinity-based probes.
@en
P2093
Grace Y J Chen
Haibin Shi
Shao Q Yao
P304
P356
10.1021/JA208518U
P407
P577
2012-02-01T00:00:00Z