Target deconvolution techniques in modern phenotypic profiling.
about
Discovery and resupply of pharmacologically active plant-derived natural products: A reviewConstellation pharmacology: a new paradigm for drug discoveryTarget prediction utilising negative bioactivity data covering large chemical spaceHuman Haploid Cell Genetics Reveals Roles for Lipid Metabolism Genes in Nonapoptotic Cell DeathBIGCHEM: Challenges and Opportunities for Big Data Analysis in ChemistryExploiting polypharmacology for drug target deconvolutionThe impact of data integrity on decision making in early lead discovery.A phenotypic screening approach in cord blood-derived mast cells to identify anti-inflammatory compounds.Aptamers: new arrows to target dendritic cells.A Global Map of Lipid-Binding Proteins and Their Ligandability in Cells.Target identification for biologically active small molecules using chemical biology approaches.Development of a Novel High-Density [3H]Hypoxanthine Scintillation Proximity Assay To Assess Plasmodium falciparum GrowthIdentification of protein binding partners of small molecules using label-free methods.Proteome-scale Binary Interactomics in Human Cells.Proteome-wide drug and metabolite interaction mapping by thermal-stability profiling.Ligand and Target Discovery by Fragment-Based Screening in Human Cells.How Reliable Are Ligand-Centric Methods for Target Fishing?Development of the Theta Comparative Cell Scoring Method to Quantify Diverse Phenotypic Responses Between Distinct Cell Types.Non-clinical studies required for new drug development - Part I: early in silico and in vitro studies, new target discovery and validation, proof of principles and robustness of animal studies.Small-molecule probes elucidate global enzyme activity in a proteomic context.Proteomics of osteosarcoma.Biological networks and drug discovery--where do we stand?Anti-dementia Activity of Nobiletin, a Citrus Flavonoid: A Review of Animal Studies.Proteolysis mediated by cysteine cathepsins and legumain-recent advances and cell biological challenges.The use of high-throughput screening in identifying chemotherapeutic agents for gastric cancer.Addressing the right targets in oncology: challenges and alternative approaches.Affinity purification in target identification: the specificity challenge.High-content drug screening for rare diseases.Novel drug discovery for Chagas disease.Next-generation phenotypic screening.Phenotypic screening with primary neurons to identify drug targets for regeneration and degeneration.Specific modulation of protein activity by using a bioorthogonal reaction.Predicting the Reliability of Drug-target Interaction Predictions with Maximum Coverage of Target Space.Tissue clearing for optical anatomy.Utilizing random Forest QSAR models with optimized parameters for target identification and its application to target-fishing server.In silico profiling of systemic effects of drugs to predict unexpected interactions.Methods to validate Hsp90 inhibitor specificity, to identify off-target effects, and to rethink approaches for further clinical development.Chemical Genetic Screen Identifies Natural Products that Modulate Centriole Number.Target Identification of Kinase Inhibitor Alisertib (MLN8237) by Using DNA-Programmed Affinity Labeling.Target Deconvolution Efforts on Wnt Pathway Screen Reveal Dual Modulation of Oxidative Phosphorylation and SERCA2.
P2860
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P2860
Target deconvolution techniques in modern phenotypic profiling.
description
2013 nî lūn-bûn
@nan
2013 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2013 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
name
Target deconvolution techniques in modern phenotypic profiling.
@ast
Target deconvolution techniques in modern phenotypic profiling.
@en
Target deconvolution techniques in modern phenotypic profiling.
@nl
type
label
Target deconvolution techniques in modern phenotypic profiling.
@ast
Target deconvolution techniques in modern phenotypic profiling.
@en
Target deconvolution techniques in modern phenotypic profiling.
@nl
prefLabel
Target deconvolution techniques in modern phenotypic profiling.
@ast
Target deconvolution techniques in modern phenotypic profiling.
@en
Target deconvolution techniques in modern phenotypic profiling.
@nl
P2860
P1476
Target deconvolution techniques in modern phenotypic profiling
@en
P2860
P304
P356
10.1016/J.CBPA.2012.12.022
P577
2013-01-18T00:00:00Z