The MIG-2/integrin interaction strengthens cell-matrix adhesion and modulates cell motility.
about
Kindlin-2 is required for myocyte elongation and is essential for myogenesisKindlin-2 regulates podocyte adhesion and fibronectin matrix deposition through interactions with phosphoinositides and integrinsStructural basis of phosphoinositide binding to kindlin-2 protein pleckstrin homology domain in regulating integrin activationA point mutation in KINDLIN3 ablates activation of three integrin subfamilies in humansStructural basis of the migfilin-filamin interaction and competition with integrin beta tailsMigfilin, a molecular switch in regulation of integrin activationKindlin 2 forms a transcriptional complex with β-catenin and TCF4 to enhance Wnt signallingThe integrin co-activator Kindlin-3 is expressed and functional in a non-hematopoietic cell, the endothelial cell.Kindlin-1 and -2 directly bind the C-terminal region of beta integrin cytoplasmic tails and exert integrin-specific activation effectsFermitins, the orthologs of mammalian Kindlins, regulate the development of a functional cardiac syncytium in Drosophila melanogasterMolecular Basis of Kindlin-2 Binding to Integrin-linked Kinase Pseudokinase for Regulating Cell AdhesionAn integrin phosphorylation switch: the effect of beta3 integrin tail phosphorylation on Dok1 and talin bindingThe Structure of the N-Terminus of Kindlin-1: A Domain Important for αIIbβ3 Integrin ActivationStructural and Functional Characterization of the Kindlin-1 Pleckstrin Homology DomainMembrane Binding of the N-Terminal Ubiquitin-Like Domain of kindlin-2 Is Crucial for Its Regulation of Integrin ActivationCrystal structure of kindlin-2 PH domain reveals a conformational transition for its membrane anchoring and regulation of integrin activationKindlin-2 controls bidirectional signaling of integrinsKindlin-2 tyrosine phosphorylation and interaction with Src serve as a regulatable switch in the integrin outside-in signaling circuit.C-terminal COOH of integrin β1 is necessary for β1 association with the kindlin-2 adapter protein.Integrin-associated complexes form hierarchically with variable stoichiometry in nascent adhesionsAssociation between α4 integrin cytoplasmic tail and non-muscle myosin IIA regulates cell migrationTranscriptomic profiling of bovine IVF embryos revealed candidate genes and pathways involved in early embryonic developmentMigfilin interacts with Src and contributes to cell-matrix adhesion-mediated survival signaling.Recreation of the terminal events in physiological integrin activation.ADAP interactions with talin and kindlin promote platelet integrin αIIbβ3 activation and stable fibrinogen binding.Exploring the Genetic Resistance to Gastrointestinal Nematodes Infection in Goat Using RNA-Sequencing.Structural and mechanical functions of integrins.Direct interaction of kindlin-3 with integrin αIIbβ3 in platelets is required for supporting arterial thrombosis in mice.Kindlins, integrin activation and the regulation of talin recruitment to αIIbβ3.PDZ and LIM domain protein 1(PDLIM1)/CLP36 promotes breast cancer cell migration, invasion and metastasis through interaction with α-actinin.Differences in binding to the ILK complex determines kindlin isoform adhesion localization and integrin activationSpatial coordination of kindlin-2 with talin head domain in interaction with integrin β cytoplasmic tailsTransmembrane and cytoplasmic domains in integrin activation and protein-protein interactions (review).Kindlin 2 regulates myogenic related factor myogenin via a canonical Wnt signaling in myogenic differentiation.Emergence and subsequent functional specialization of kindlins during evolution of cell adhesiveness.Site-specific phosphorylation of kindlin-3 protein regulates its capacity to control cellular responses mediated by integrin αIIbβ3.Interaction of kindlin-2 with integrin β3 promotes outside-in signaling responses by the αVβ3 vitronectin receptorReconstruction of integrin activation.Kindlin-2 controls TGF-β signalling and Sox9 expression to regulate chondrogenesisCritical role of filamin-binding LIM protein 1 (FBLP-1)/migfilin in regulation of bone remodeling.
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P2860
The MIG-2/integrin interaction strengthens cell-matrix adhesion and modulates cell motility.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年学术文章
@wuu
2007年学术文章
@zh
2007年学术文章
@zh-cn
2007年学术文章
@zh-hans
2007年学术文章
@zh-my
2007年学术文章
@zh-sg
2007年學術文章
@yue
2007年學術文章
@zh-hant
name
The MIG-2/integrin interaction ...... n and modulates cell motility.
@en
The MIG-2/integrin interaction ...... n and modulates cell motility.
@nl
type
label
The MIG-2/integrin interaction ...... n and modulates cell motility.
@en
The MIG-2/integrin interaction ...... n and modulates cell motility.
@nl
prefLabel
The MIG-2/integrin interaction ...... n and modulates cell motility.
@en
The MIG-2/integrin interaction ...... n and modulates cell motility.
@nl
P2093
P2860
P356
P1476
The MIG-2/integrin interaction ...... on and modulates cell motility
@en
P2093
Chuanyue Wu
Edward F Plow
Koichi Fukuda
Xiaohua Shi
Yan-Qing Ma
P2860
P304
20455-20466
P356
10.1074/JBC.M611680200
P407
P50
P577
2007-05-18T00:00:00Z