The N-terminal transmembrane domain (TMD0) and a cytosolic linker (L0) of sulphonylurea receptor define the unique intrinsic gating of KATP channels.
about
How ATP inhibits the open K(ATP) channelThe molecular mechanisms and pharmacotherapy of ATP-sensitive potassium channel gene mutations underlying neonatal diabetesMeasuring and evaluating the role of ATP-sensitive K+ channels in cardiac muscle.Kir6.2 activation by sulfonylurea receptors: a different mechanism of action for SUR1 and SUR2A subunits via the same residues.Sulfonylurea receptors type 1 and 2A randomly assemble to form heteromeric KATP channels of mixed subunit compositionRole for SUR2A ED domain in allosteric coupling within the K(ATP) channel complex.Current understanding of K ATP channels in neonatal diseases: focus on insulin secretion disorders.Coassembly of different sulfonylurea receptor subtypes extends the phenotypic diversity of ATP-sensitive potassium (KATP) channels.Phosphorylation-dependent changes in nucleotide binding, conformation, and dynamics of the first nucleotide binding domain (NBD1) of the sulfonylurea receptor 2B (SUR2B).Compound heterozygous mutations in the SUR1 (ABCC 8) subunit of pancreatic K(ATP) channels cause neonatal diabetes by perturbing the coupling between Kir6.2 and SUR1 subunits.Three C-terminal residues from the sulphonylurea receptor contribute to the functional coupling between the K(ATP) channel subunits SUR2A and Kir6.2.Remodelling of the SUR-Kir6.2 interface of the KATP channel upon ATP binding revealed by the conformational blocker rhodamine 123.Cantu syndrome-associated SUR2 (ABCC9) mutations in distinct structural domains result in KATP channel gain-of-function by differential mechanisms.Expression, purification, and electrophysiological characterization of a recombinant, fluorescent Kir6.2 in mammalian cells.Cryo-electron microscopy structures and progress toward a dynamic understanding of KATP channels.New insights into the roles of the N-terminal region of the ABCC6 transporter.Membrane insertion and topology of the amino-terminal domain TMD0 of multidrug-resistance associated protein 6 (MRP6).
P2860
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P2860
The N-terminal transmembrane domain (TMD0) and a cytosolic linker (L0) of sulphonylurea receptor define the unique intrinsic gating of KATP channels.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年学术文章
@wuu
2006年学术文章
@zh
2006年学术文章
@zh-cn
2006年学术文章
@zh-hans
2006年学术文章
@zh-my
2006年学术文章
@zh-sg
2006年學術文章
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2006年學術文章
@zh-hant
name
The N-terminal transmembrane d ...... insic gating of KATP channels.
@en
The N-terminal transmembrane domain
@nl
type
label
The N-terminal transmembrane d ...... insic gating of KATP channels.
@en
The N-terminal transmembrane domain
@nl
prefLabel
The N-terminal transmembrane d ...... insic gating of KATP channels.
@en
The N-terminal transmembrane domain
@nl
P2860
P1476
The N-terminal transmembrane d ...... insic gating of KATP channels.
@en
P2093
P2860
P304
P356
10.1113/JPHYSIOL.2006.112748
P407
P577
2006-08-03T00:00:00Z