The tumor necrosis factor family receptors RANK and CD40 cooperatively establish the thymic medullary microenvironment and self-tolerance. - Wikidata - awgldk - TriplyDB

The tumor necrosis factor family receptors RANK and CD40 cooperatively establish the thymic medullary microenvironment and self-tolerance.

The tumor necrosis factor family receptors RANK and CD40 cooperatively establish the thymic medullary microenvironment and self-tolerance.

http://www.wikidata.org/entity/Q51949099

about

Emerging Functions of RANKL in Lymphoid Tissues Post-Aire Maturation of Thymic Medullary Epithelial Cells Involves Selective Expression of Keratinocyte-Specific Autoantigens CD154: an immunoinflammatory mediator in systemic lupus erythematosus and rheumatoid arthritis Expression of the autoimmune regulator gene and its relevance to the mechanisms of central and peripheral tolerance Aire and T cell development Transcriptional regulation by AIRE: molecular mechanisms of central tolerance RANK-RANKL signalling in cancer Control of the thymic medulla and its influence on αβT-cell development Positive and Negative Regulatory Mechanisms for Fine-Tuning Cellularity and Functions of Medullary Thymic Epithelial Cells Thymic B Cells and Central T Cell Tolerance Thymic Crosstalk Coordinates Medulla Organization and T-Cell Tolerance Induction Ubiquitin in the immune system Thymic epithelial cell development and differentiation: cellular and molecular regulation Antigen recognition by autoreactive CD4⁺ thymocytes drives homeostasis of the thymic medulla Identification of novel thymic epithelial cell subsets whose differentiation is regulated by RANKL and Traf6 Adult thymic epithelial cell (TEC) progenitors and TEC stem cells: Models and mechanisms for TEC development and maintenance Germline mutations in NFKB2 implicate the noncanonical NF-κB pathway in the pathogenesis of common variable immunodeficiency RANKL/RANK-beyond bones Foxn1 regulates lineage progression in cortical and medullary thymic epithelial cells but is dispensable for medullary sublineage divergence RANKL Is Necessary and Sufficient to Initiate Development of Antigen-Sampling M Cells in the Intestinal Epithelium T cell progenitor therapy-facilitated thymopoiesis depends upon thymic input and continued thymic microenvironment interaction.DKK1 mediated inhibition of Wnt signaling in postnatal mice leads to loss of TEC progenitors and thymic degeneration.Enhancement of an anti-tumor immune response by transient blockade of central T cell tolerance.Exploring codon optimization and response surface methodology to express biologically active transmembrane RANKL in E. coli.ADAM17 deletion in thymic epithelial cells alters aire expression without affecting T cell developmental progression Thymic homing of activated CD4+ T cells induces degeneration of the thymic epithelium through excessive RANK signaling.Administration of RANKL boosts thymic regeneration upon bone marrow transplantation Roles of the NF-kappaB pathway in lymphocyte development and function.Regulation of medullary thymic epithelial cell differentiation and function by the signaling protein Sin.TRAF3 regulates homeostasis of CD8+ central memory T cells.Rare development of Foxp3+ thymocytes in the CD4+CD8+ subset Engineering the human thymic microenvironment to support thymopoiesis in vivo.Selective targeting of RANK signaling pathways as new therapeutic strategies for osteoporosis.Direct and indirect roles of the LTbetaR pathway in central tolerance induction.Preformed CD40L is stored in Th1, Th2, Th17, and T follicular helper cells as well as CD4+ 8- thymocytes and invariant NKT cells but not in Treg cells.Control of central and peripheral tolerance by Aire.Receptor activator of NF-kappaB and podocytes: towards a function of a novel receptor-ligand pair in the survival response of podocyte injury.Biology of the RANKL-RANK-OPG System in Immunity, Bone, and Beyond.Regeneration of the aged thymus by a single transcription factor.DNA methylation profile of Aire-deficient mouse medullary thymic epithelial cells

P2860

Q21131222-B08AD4DB-1E00-422F-AB87-36E6F4BFED98 Q21131226-CEB20BE8-D5EE-41A7-B198-183A372C3BB0 Q21285053-07A5B9A1-0519-4AE5-9B9E-0FA2BA842276 Q21296698-8CDAA0B0-1E1B-482A-BC8C-3381C02107A3 Q24621103-ADD22B2B-0097-4465-9A45-5140DAE94C69 Q24648384-D4AC3870-2DBF-4D42-A964-41118F30D517 Q26747442-83B4A6ED-70A3-4902-B03B-007594EB0915 Q26752793-F90E5390-4FF3-4F40-944E-98B5AB715EE1 Q26781312-348C5795-C54E-4760-B155-C23FF8126205 Q26800127-01226171-19B5-4CC2-A4CA-4A5A095DF314 Q26800152-48566513-6B1C-4BB5-AD0A-A70C4F62C132 Q26998711-E6239737-9E35-41D8-B49F-796037C3E494 Q27004003-29FC9067-CA7F-43A9-BA94-E6EA863C4EEB Q27324446-E35377C3-1BC6-4AEE-9912-254DA753D579 Q27331912-49F41398-047C-41FA-AB56-EE866978201D Q28083721-0C3FFF6C-B4E7-48FE-A54D-540FB99F0F1B Q28300499-FAD010F6-9DAB-4543-A9CB-D4B87EA25C19 Q28308042-6A8395F9-3B3D-4AF4-B227-63A2F7CDDA79 Q28589335-DE242E49-95D9-49AE-83A3-18EE8B11FC0F Q29397534-00683E0D-37C9-4DBA-AE20-07B6A9C6DD0F Q30851570-BB07ADB6-1DE0-4E69-9548-944F2B4D36D1 Q33531736-31260627-7CD0-4548-9AFE-FE3FA293BE6A Q33569842-77607DA8-F22A-403E-AF21-E2A14A388C93 Q33583910-BFDF0F41-A38D-4F0F-B2C8-D6D36762D82E Q33728091-8758E6BF-8130-44D5-85D5-1CEA193B5796 Q33729251-A494A668-31F4-4617-934D-155FA41E98B8 Q33748998-2C8DA088-1016-4422-9D77-F9507646A2D4 Q33800318-9094B8FA-7A34-4490-82E4-41889D569EB6 Q33839955-CFFFCD41-93E7-482F-9A82-A642108EB46B Q33882681-800EBB69-288A-4DB0-A251-FA6C9F0154E9 Q34029110-F5378499-56EE-4394-ACBA-677D48B6BF94 Q34066833-DC8B9A4B-822C-4B87-B78C-A1A38B269D40 Q34090842-127C2AD3-0669-4F57-8E10-8FCF3C9034C2 Q34103805-7B0F0253-649F-4D65-8627-5957A9BFCC40 Q34170759-54DE9E32-DC8C-46DB-9553-A39C8B1F1A27 Q34177944-3E9970F8-375D-45BE-993E-17D0976ADBB5 Q34358320-9B51FDD2-9202-4D2E-9160-A5225D910136 Q34366449-4E5BDCBF-DC83-4010-A8D6-79EC7005D197 Q34414351-0E5EBA76-4145-4232-B77B-3950E3FD0EBA Q34463678-7F85CE5C-3B69-44B6-8B54-516CE44DBE37

P2860

The tumor necrosis factor family receptors RANK and CD40 cooperatively establish the thymic medullary microenvironment and self-tolerance.

http://www.wikidata.org/entity/Q51949099

description

2008 nî lūn-bûn

@nan

2008年の論文

@ja

2008年学术文章

@wuu

2008年学术文章

@zh

2008年学术文章

@zh-cn

2008年学术文章

@zh-hans

2008年学术文章

@zh-my

2008年学术文章

@zh-sg

2008年學術文章

@yue

2008年學術文章

@zh-hant

name

The tumor necrosis factor fami ...... nvironment and self-tolerance.

@en

The tumor necrosis factor fami ...... nvironment and self-tolerance.

@nl

type

label

The tumor necrosis factor fami ...... nvironment and self-tolerance.

@en

The tumor necrosis factor fami ...... nvironment and self-tolerance.

@nl

prefLabel

The tumor necrosis factor fami ...... nvironment and self-tolerance.

@en

The tumor necrosis factor fami ...... nvironment and self-tolerance.

@nl

P1433

Q51949099-2B5945DE-F60B-4062-880F-F3A23717A481

P1476

Q51949099-B42126A8-166F-459C-BE0D-DF8AB5F1565E

P2093

Q51949099-02C59B64-6743-40C0-A87A-948BF6E57FEB

Q51949099-1BA75EB7-BF27-4155-88A3-463939BDC584

Q51949099-249D9C31-809C-415E-8233-6461CDC9E51B

Q51949099-48D1A298-3E07-426D-8D73-AA137974D56C

Q51949099-834C7865-40C9-42D7-A7CE-1C167BCAEC09

Q51949099-A34C657A-4C26-456D-90B8-A77B52750F6F

Q51949099-AD2CFACA-0387-4D46-B809-60EDBE2F6734

Q51949099-DC5AD3DD-A80C-48B9-9BAE-C29F6BF8B16C

Q51949099-DE471179-D53E-48A9-BFF0-9EB7F11AF672

Q51949099-ED2D019C-81C7-40EC-8F98-0E04763CA190

P304

Q51949099-B538E344-05BF-4228-AA2A-D2EB0D63740A

P31

Q51949099-9A2CB614-9834-4E4D-BE00-189A62EFBE79

P356

Q51949099-AAF04EE2-FB6E-4DFA-B419-9C43CBE0F7FC

P407

Q51949099-7AAB3974-1F4A-4DBB-B2AD-F8BC7B972A36

P433

Q51949099-CD8FEFFC-3BF0-47EA-9BF3-199EDE675540

P478

Q51949099-446FFC7B-0EE3-4C6C-98AA-3A5DFABB6AEA

P50

Q51949099-367C0FFC-D1B1-4029-B321-57707221A46B

Q51949099-8757AD4B-2BD5-4B37-B9B0-C53B680095B4

Q51949099-C2B952DF-86D8-4ABD-8F20-DEFAE86FF3D1

P577

Q51949099-9D44AA75-901B-4D07-9631-2DD25E89E17F

P5875

Q51949099-9F054AD1-561D-456C-BB2B-480EF709C171

P698

Q51949099-A16DFE58-8C69-4778-B250-47F23633A605

P356

J.IMMUNI.2008.06.015

P1433

P1476

The tumor necrosis factor fami ...... nvironment and self-tolerance.

@en

P2093

Daisuke Ohshima

http://www.w3.org/2001/XMLSchema#string

Hiromi Yanai

http://www.w3.org/2001/XMLSchema#string

Hiroshi Takayanagi

http://www.w3.org/2001/XMLSchema#string

Juli Kitazawa

http://www.w3.org/2001/XMLSchema#string

Jun-Ichiro Inoue

http://www.w3.org/2001/XMLSchema#string

Junwen Qin

http://www.w3.org/2001/XMLSchema#string

Mitsuru Matsumoto

http://www.w3.org/2001/XMLSchema#string

Takeshi Nitta

http://www.w3.org/2001/XMLSchema#string

Yousuke Takahama

http://www.w3.org/2001/XMLSchema#string

Yukiko Asaumi

http://www.w3.org/2001/XMLSchema#string

P304

423-437

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1016/J.IMMUNI.2008.06.015

http://www.w3.org/2001/XMLSchema#string

P407

P433

3

http://www.w3.org/2001/XMLSchema#string

P478

29

http://www.w3.org/2001/XMLSchema#string

P50

Josef M Penninger

Taishin Akiyama

P577

2008-09-01T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

23263228

http://www.w3.org/2001/XMLSchema#string

P698

18799149

http://www.w3.org/2001/XMLSchema#string