Gamma-secretase/presenilin inhibitors for Alzheimer's disease phenocopy Notch mutations in Drosophila.
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Notch signaling maintains neural rosette polaritySmall molecule suppressors of Drosophila kinesin deficiency rescue motor axon development in a zebrafish model of spinal muscular atrophyNotch is a critical component of the mouse somitogenesis oscillator and is essential for the formation of the somitesNotch signalling mediates reproductive constraint in the adult worker honeybeeInhibition of Notch activity promotes nonmitotic regeneration of hair cells in the adult mouse utriclesNotch signaling regulates regeneration in the avian retina.Presenilin controls kinesin-1 and dynein function during APP-vesicle transport in vivoIn vivo analysis of compound activity and mechanism of action using epistasis in Drosophila.Drosophotoxicology: the growing potential for Drosophila in neurotoxicologyTransgenic Drosophila models of Alzheimer's disease and tauopathiesAllosteric regulation of γ-secretase activity by a phenylimidazole-type γ-secretase modulator.Notch signaling change in pulmonary vascular remodeling in rats with pulmonary hypertension and its implication for therapeutic intervention.Human disease models in Drosophila melanogaster and the role of the fly in therapeutic drug discovery.Three-dimensional structure of the signal peptide peptidaseShp2 signaling suppresses senescence in PyMT-induced mammary gland cancer in mice.Drosophila models of proteinopathies: the little fly that could.An NSAID-like compound, FT-9, preferentially inhibits gamma-secretase cleavage of the amyloid precursor protein compared to its effect on amyloid precursor-like protein 1.All-trans-retinoic Acid Modulates the Plasticity and Inhibits the Motility of Breast Cancer Cells: ROLE OF NOTCH1 AND TRANSFORMING GROWTH FACTOR (TGFβ).Regulation of Nematostella neural progenitors by SoxB, Notch and bHLH genes.The Notch pathway in ovarian carcinomas and adenomas.Chemical technologies for probing embryonic developmentPostnatal dysregulation of Notch signal disrupts dendrite development of adult-born neurons in the hippocampus and contributes to memory impairmentGamma-secretase activation of notch signaling regulates the balance of proximal and distal fates in progenitor cells of the developing lung.The Notch signaling inhibitor DAPT down-regulates cdk5 activity and modulates the distribution of neuronal cytoskeletal proteins.Phase 2 safety trial targeting amyloid beta production with a gamma-secretase inhibitor in Alzheimer diseaseNotch signaling regulates venous arterialization during zebrafish fin regeneration.Notch activation induces endothelial cell cycle arrest and participates in contact inhibition: role of p21Cip1 repressionCyclic Nrarp mRNA expression is regulated by the somitic oscillator but Nrarp protein levels do not oscillate.Interactions between lens epithelial and fiber cells reveal an intrinsic self-assembly mechanism.Pharmacologic inhibition of vacuolar H+ ATPase reduces physiologic and oncogenic Notch signaling.Contribution of the γ-secretase subunits to the formation of catalytic pore of presenilin 1 protein.JNK activity in somatic stem cells causes loss of tissue homeostasis in the aging Drosophila gut.Presenilin 1 affects focal adhesion site formation and cell force generation via c-Src transcriptional and posttranslational regulation.Functional overexpression of gamma-secretase reveals protease-independent trafficking functions and a critical role of lipids for protease activity.And Lophotrochozoa makes three: Notch/Hes signaling in annelid segmentation.Transient inactivation of Notch signaling synchronizes differentiation of neural progenitor cells.Molecular signatures of neurodegeneration in the cortex of PS1/PS2 double knockout mice.Abeta42-lowering nonsteroidal anti-inflammatory drugs preserve intramembrane cleavage of the amyloid precursor protein (APP) and ErbB-4 receptor and signaling through the APP intracellular domain.RAGE mediates Aβ accumulation in a mouse model of Alzheimer's disease via modulation of β- and γ-secretase activity.Functional studies on the role of Notch signaling in Hydractinia development.
P2860
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P2860
Gamma-secretase/presenilin inhibitors for Alzheimer's disease phenocopy Notch mutations in Drosophila.
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年学术文章
@wuu
2002年学术文章
@zh
2002年学术文章
@zh-cn
2002年学术文章
@zh-hans
2002年学术文章
@zh-my
2002年学术文章
@zh-sg
2002年學術文章
@yue
2002年學術文章
@zh-hant
name
Gamma-secretase/presenilin inh ...... Notch mutations in Drosophila.
@en
Gamma-secretase/presenilin inh ...... Notch mutations in Drosophila.
@nl
type
label
Gamma-secretase/presenilin inh ...... Notch mutations in Drosophila.
@en
Gamma-secretase/presenilin inh ...... Notch mutations in Drosophila.
@nl
prefLabel
Gamma-secretase/presenilin inh ...... Notch mutations in Drosophila.
@en
Gamma-secretase/presenilin inh ...... Notch mutations in Drosophila.
@nl
P2093
P356
P1433
P1476
Gamma-secretase/presenilin inh ...... Notch mutations in Drosophila.
@en
P2093
Anna Kornilova
Christine Jack
Craig A Micchelli
Michael S Wolfe
Oksana Berezovska
W Taylor Kimberly
William P Esler
P356
10.1096/FJ.02-0394FJE
P407
P577
2002-11-01T00:00:00Z