Thymidylate synthetase: mechanism of inhibition by 5-fluoro-2'-deoxyuridylate.
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Promotion of purine nucleotide binding to thymidylate synthase by a potent folate analogue inhibitor, 1843U89A Fluorescent Probe to Measure DNA Damage and RepairPrognostic significance of 5-fluorouracil metabolism-relating enzymes and enhanced chemosensitivity to 5-fluorouracil by 5-chloro 2,4-dihydroxy-pyridine in urothelial carcinoma.Functional role of cysteine-146 in Escherichia coli thymidylate synthase.The cause of neural tube defects: some experiments and a hypothesis.Cytotoxicity of 5-fluoro-2'-deoxyuridine: requirement for reduced folate cofactors and antagonism by methotrexate.Repeated oral dosing of TAS-102 confers high trifluridine incorporation into DNA and sustained antitumor activity in mouse models.Biochemical determinants of 5-fluorouracil response in vivo. The role of deoxyuridylate pool expansion.Pyrimidine nucleoside phosphorylase activity in tumour and matched normal gastrointestinal mucosaIncorporation of intermediary products of 5-FU anabolism into colorectal cancerAnalysis of the mRNA expression of chemotherapy-related genes in colorectal carcinoma using the danenberg tumor profile methodNew challenges and inspired answers for anticancer drug discovery and developmentAmino acid sequence at the FdUMP binding site of thymidylate synthetaseA practical approach for assessing chemosensitivity in colorectal cancer cell lines by comparative analysis of cell viability and thymidylate synthase mRNA expression.Bacteriophage T4 baseplate components. III. Location and properties of the bacteriophage structural thymidylate synthetase.Thymidylate synthase predictive power is overcome by irinotecan combination therapy with S-1 for gastric cancer.Therapeutic enhancement of S-1 with CPT-11 through down-regulation of thymidylate synthase in bladder cancer.Thymidylate synthetase purified to homogeneity from human leukemic cells.Biochemical determinants of tumor sensitivity to 5-fluorouracil: ultrasensitive methods for the determination of 5-fluoro-2'-deoxyuridylate, 2'-deoxyuridylate, and thymidylate synthetase.Deoxyuridine analog nucleotides in deoxycytidine analog treatment: secondary active metabolites?Suicidal gene therapy in the effective control of primary human hepatocellular carcinoma as monitored by noninvasive bioimaging.The potential use of mechanism-based enzyme inactivators in medicine.Gene expression analysis using human cancer xenografts to identify novel predictive marker genes for the efficacy of 5-fluorouracil-based drugs.Sequence-specific and mechanism-based crosslinking of Dcm DNA cytosine-C5 methyltransferase of E. coli K-12 to synthetic oligonucleotides containing 5-fluoro-2'-deoxycytidine.Synthesis of 1-(2-deoxy-beta-D-ribofuranosyl)-2,4-difluoro-5-substituted-benzenes: "thymine replacement" analogs of thymidine for evaluation as anticancer and antiviral agents.Synthesis of 1-(2-deoxy-beta-D-ribofuranosyl)-2,4-difluoro-5-substituted-benzene thymidine mimics, some related alpha-anomers, and their evaluation as antiviral and anticancer agents.Targeted delivery of an anti-cancer agent via steroid coupled liposomes.Determination of the rates of synthesis and degradation of enzymes by complex formation with radioactive ligands.Synthesis of unnatural 7-substituted-1-(2-deoxy-beta-D-ribofuranosyl)isocarbostyrils: "thymine replacement" analogs of deoxythymidine for evaluation as antiviral and anticancer agents.Predictive value of dihydropyrimidine dehydrogenase expression in tumor tissue, regarding the efficacy of postoperatively administered UFT (Tegafur + Uracil) in patients with p-stage I nonsmall-cell lung cancer.Quantitative measurement of thymidylate synthase and dihydropyrimidine dehydrogenase mRNA level in gastric cancer by real-time RT-PCR.Clinical significance of dihydropyrimidine dehydrogenase in adjuvant 5-fluorouracil liver perfusion chemotherapy for pancreatic cancer.A randomized clinical trial with a weekly regimen of 5-fluorouracil with or without folinic acid in advanced gastrointestinal adenocarcinomas: a preliminary report.Characterization of 5-fluorouracil microspheres for colonic delivery.Combined efficacy and mechanism of trifluridine and SN-38 in a 5-FU-resistant human colorectal cancer cell lines.Dihydropyrimidine dehydrogenase and messenger RNA levels in gastric cancer: possible predictor for sensitivity to 5-fluorouracil.Genome-wide screening of loci associated with drug resistance to 5-fluorouracil-based drugs.UCN-01 (7-hydroxystaurosporine) enhances 5-fluorouracil cytotoxicity through down-regulation of thymidylate synthetase messenger RNA.Competitive binding radioassay for the determination of 5-fluorodeoxyuridine and 5-fluorodeoxyuridine-5'-monophosphate levels in plasma and tumor tissue.Regulation of dihydropyrimidine dehydrogenase and pyrimidine nucleoside phosphorylase activities by growth factors and subsequent effects on 5-fluorouracil sensitivity in tumor cells.
P2860
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P2860
Thymidylate synthetase: mechanism of inhibition by 5-fluoro-2'-deoxyuridylate.
description
1972 nî lūn-bûn
@nan
1972年の論文
@ja
1972年学术文章
@wuu
1972年学术文章
@zh
1972年学术文章
@zh-cn
1972年学术文章
@zh-hans
1972年学术文章
@zh-my
1972年学术文章
@zh-sg
1972年學術文章
@yue
1972年學術文章
@zh-hant
name
Thymidylate synthetase: mechanism of inhibition by 5-fluoro-2'-deoxyuridylate.
@en
Thymidylate synthetase: mechanism of inhibition by 5-fluoro-2'-deoxyuridylate.
@nl
type
label
Thymidylate synthetase: mechanism of inhibition by 5-fluoro-2'-deoxyuridylate.
@en
Thymidylate synthetase: mechanism of inhibition by 5-fluoro-2'-deoxyuridylate.
@nl
prefLabel
Thymidylate synthetase: mechanism of inhibition by 5-fluoro-2'-deoxyuridylate.
@en
Thymidylate synthetase: mechanism of inhibition by 5-fluoro-2'-deoxyuridylate.
@nl
P2093
P1476
Thymidylate synthetase: mechanism of inhibition by 5-fluoro-2'-deoxyuridylate.
@en
P2093
Danenberg PV
Heidelberger C
Langenbach RJ
P304
P356
10.1016/0006-291X(72)90892-3
P407
P577
1972-09-01T00:00:00Z