Targeted disruption of the homeobox transcription factor Bapx1 results in lethal skeletal dysplasia with asplenia and gastroduodenal malformation.
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A novel LIM protein Cal promotes cardiac differentiation by association with CSX/NKX2-5The role of Bapx1 (Nkx3.2) in the development and evolution of the axial skeletonEstablishment of vertebrate left-right asymmetryMeox homeodomain proteins are required for Bapx1 expression in the sclerotome and activate its transcription by direct binding to its promoterNkx3.2-mediated repression of Runx2 promotes chondrogenic differentiationLack of the mesodermal homeodomain protein MEOX1 disrupts sclerotome polarity and leads to a remodeling of the cranio-cervical joints of the axial skeletonRole of the homeodomain transcription factor Bapx1 in mouse distal stomach developmentApoptosis in neural crest cells by functional loss of APC tumor suppressor geneNkx3.2 promotes primary chondrogenic differentiation by upregulating Col2a1 transcriptionIn vivo genome-wide analysis of multiple tissues identifies gene regulatory networks, novel functions and downstream regulatory genes for Bapx1 and its co-regulation with Sox9 in the mammalian vertebral column.Spleen versus pancreas: strict control of organ interrelationship revealed by analyses of Bapx1-/- mice.Shh establishes an Nkx3.2/Sox9 autoregulatory loop that is maintained by BMP signals to induce somitic chondrogenesis.Angiotensin II receptor blockade promotes repair of skeletal muscle through down-regulation of aging-promoting C1q expression.The molecular mechanisms of stomach development in vertebrates.Abnormal lymphoid organ development in immunodeficient mutant mice.Suppression of Nkx3.2 by phosphatidylinositol-3-kinase signaling regulates cartilage development by modulating chondrocyte hypertrophy.A gradient of Shh establishes mutually repressing somitic cell fates induced by Nkx3.2 and Pax3.Sox9 directly promotes Bapx1 gene expression to repress Runx2 in chondrocytes.Interpreting neonatal lethal phenotypes in mouse mutants: insights into gene function and human diseases.Homozygous inactivating mutations in the NKX3-2 gene result in spondylo-megaepiphyseal-metaphyseal dysplasia.Left-right asymmetry in gut development: what happens next?The chondrocytic journey in endochondral bone growth and skeletal dysplasia.Whole-Genome Sequencing Coupled to Imputation Discovers Genetic Signals for Anthropometric Traits.The role of Nkx3.2 in chondrogenesis.Developmental mechanisms of intervertebral disc and vertebral column formation.New Bapx1(Cre-EGFP) mouse lines for lineage tracing and conditional knockout studies.Constitutive RelA activation mediated by Nkx3.2 controls chondrocyte viability.Proper development of the outer longitudinal smooth muscle of the mouse pylorus requires Nkx2-5 and Gata3.Molecular study of a Hoxa2 gain-of-function in chondrogenesis: a model of idiopathic proportionate short stature.Indian Hedgehog signalling triggers Nkx3.2 protein degradation during chondrocyte maturation.Characterization of Nkx3.2 DNA binding specificity and its requirement for somitic chondrogenesis.Genes uniquely expressed in human growth plate chondrocytes uncover a distinct regulatory network.Development of the head and trunk mesoderm in the dogfish, Scyliorhinus torazame: II. Comparison of gene expression between the head mesoderm and somites with reference to the origin of the vertebrate head.Cartilage-Specific and Cre-Dependent Nkx3.2 Overexpression In Vivo Causes Skeletal Dwarfism by Delaying Cartilage Hypertrophy.BAPX-1/NKX-3.2 acts as a chondrocyte hypertrophy molecular switch in osteoarthritis.
P2860
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P2860
Targeted disruption of the homeobox transcription factor Bapx1 results in lethal skeletal dysplasia with asplenia and gastroduodenal malformation.
description
2000 nî lūn-bûn
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2000年学术文章
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2000年学术文章
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2000年学术文章
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name
Targeted disruption of the hom ...... d gastroduodenal malformation.
@en
Targeted disruption of the hom ...... d gastroduodenal malformation.
@nl
type
label
Targeted disruption of the hom ...... d gastroduodenal malformation.
@en
Targeted disruption of the hom ...... d gastroduodenal malformation.
@nl
prefLabel
Targeted disruption of the hom ...... d gastroduodenal malformation.
@en
Targeted disruption of the hom ...... d gastroduodenal malformation.
@nl
P2093
P2860
P1433
P1476
Targeted disruption of the hom ...... d gastroduodenal malformation.
@en
P2093
P2860
P304
P356
10.1046/J.1365-2443.2000.00339.X
P577
2000-06-01T00:00:00Z