Thioamide substitution to probe the hydroxyproline recognition of VHL ligands.

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Thioamide substitution to probe the hydroxyproline recognition of VHL ligands.

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2018 nî lūn-bûn

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2018年の論文

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2018年学术文章

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2018年学术文章

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2018年学术文章

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2018年学术文章

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2018年学术文章

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2018年学术文章

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2018年學術文章

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Thioamide substitution to probe the hydroxyproline recognition of VHL ligands.

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Thioamide substitution to probe the hydroxyproline recognition of VHL ligands.

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Thioamide substitution to probe the hydroxyproline recognition of VHL ligands.

@en

Thioamide substitution to probe the hydroxyproline recognition of VHL ligands.

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Thioamide substitution to probe the hydroxyproline recognition of VHL ligands.

@en

Thioamide substitution to probe the hydroxyproline recognition of VHL ligands.

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P1476

Thioamide substitution to probe the hydroxyproline recognition of VHL ligands

@en

P2093

Pedro Soares

http://www.w3.org/2001/XMLSchema#string

P2860

Structure of an HIF-1alpha -pVHL complex: hydroxyproline recognition in signaling

Structural basis for the recognition of hydroxyproline in HIF-1 alpha by pVHL

n-->pi* interactions in proteins

Structure-Guided Design and Optimization of Small Molecules Targeting the Protein–Protein Interaction between the von Hippel–Lindau (VHL) E3 Ubiquitin Ligase and the Hypoxia Inducible Factor (HIF) Alpha Subunit with in Vitro Nanomolar Affinities

Dissecting Fragment-Based Lead Discovery at the von Hippel-Lindau Protein:Hypoxia Inducible Factor 1α Protein-Protein Interface

Targeting the von Hippel–Lindau E3 Ubiquitin Ligase Using Small Molecules To Disrupt the VHL/HIF-1α Interaction

Potent and selective chemical probe of hypoxic signalling downstream of HIF-α hydroxylation via VHL inhibition

Interplay of hydrogen bonds and n→π* interactions in proteins

Effect of thioxopeptide bonds on alpha-helix structure and stability.

The effects of thioamide backbone substitution on protein stability: a study in α-helical, β-sheet, and polyproline II helical contexts

P304

2992-2995

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1016/J.BMC.2018.03.034

http://www.w3.org/2001/XMLSchema#string

P407

English

P433

http://www.w3.org/2001/XMLSchema#string

P478

http://www.w3.org/2001/XMLSchema#string

P50

Alessio Ciulli

Xavier Lucas

Pedro Soares

P577

2018-03-23T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P698

29650462

http://www.w3.org/2001/XMLSchema#string

P932

6008493

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