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Chemical genetics approaches for selective intervention in epigeneticsCyclic and Macrocyclic Peptides as Chemical Tools To Recognise Protein Surfaces and Probe Protein-Protein InteractionsStructure-Guided Design and Optimization of Small Molecules Targeting the Protein–Protein Interaction between the von Hippel–Lindau (VHL) E3 Ubiquitin Ligase and the Hypoxia Inducible Factor (HIF) Alpha Subunit with in Vitro Nanomolar AffinitiesCrystal structure of Escherichia coli ketopantoate reductase in a ternary complex with NADP+ and pantoate bound: substrate recognition, conformational change, and cooperativitypH-tuneable binding of 2′-phospho-ADP-ribose to ketopantoate reductase: a structural and calorimetric studyInhibition ofMycobacterium tuberculosisPantothenate Synthetase by Analogues of the Reaction IntermediateApplication of fragment growing and fragment linking to the discovery of inhibitors of Mycobacterium tuberculosis pantothenate synthetaseA Fragment-Based Approach to Probing Adenosine Recognition Sites by Using Dynamic Combinatorial ChemistryOptimization of the Interligand Overhauser Effect for Fragment Linking: Application to Inhibitor Discovery against Mycobacterium tuberculosis Pantothenate SynthetaseStructural investigation of inhibitor designs targeting 3-dehydroquinate dehydratase from the shikimate pathway of Mycobacterium tuberculosisDissecting Fragment-Based Lead Discovery at the von Hippel-Lindau Protein:Hypoxia Inducible Factor 1α Protein-Protein InterfaceTargeting the von Hippel–Lindau E3 Ubiquitin Ligase Using Small Molecules To Disrupt the VHL/HIF-1α InteractionMultimeric Complexes among Ankyrin-Repeat and SOCS-box Protein 9 (ASB9), ElonginBC, and Cullin 5: Insights into the Structure and Assembly of ECS-type Cullin-RING E3 Ubiquitin LigasesIntegrated biophysical approach to fragment screening and validation for fragment-based lead discoveryTargeting Low-Druggability Bromodomains: Fragment Based Screening and Inhibitor Design against the BAZ2B BromodomainIs NMR Fragment Screening Fine-Tuned to Assess Druggability of Protein–Protein Interactions?Application of fragment screening and merging to the discovery of inhibitors of the Mycobacterium tuberculosis cytochrome P450 CYP121Potent and selective chemical probe of hypoxic signalling downstream of HIF-α hydroxylation via VHL inhibitionNMR approaches in structure-based lead discovery: recent developments and new frontiers for targeting multi-protein complexesProbing hot spots at protein-ligand binding sites: a fragment-based approach using biophysical methods.Biophysical tools to monitor enzyme-ligand interactions of enzymes involved in vitamin biosynthesis.Structural basis of PROTAC cooperative recognition for selective protein degradationInvestigation of the mycobacterial enzyme HsaD as a potential novel target for anti-tubercular agents using a fragment-based drug design approach.Structure-Guided Design of Peptides as Tools to Probe the Protein-Protein Interaction between Cullin-2 and Elongin BC Substrate Adaptor in Cullin RING E3 Ubiquitin LigasesNew Synthetic Routes to Triazolo-benzodiazepine Analogues: Expanding the Scope of the Bump-and-Hole Approach for Selective Bromo and Extra-Terminal (BET) Bromodomain Inhibition.Impact of Target Warhead and Linkage Vector on Inducing Protein Degradation: Comparison of Bromodomain and Extra-Terminal (BET) Degraders Derived from Triazolodiazepine (JQ1) and Tetrahydroquinoline (I-BET726) BET Inhibitor Scaffolds.Selectivity on-target of bromodomain chemical probes by structure-guided medicinal chemistry and chemical biology.Recognition of substrate degrons by E3 ubiquitin ligases and modulation by small-molecule mimicry strategies.Targeting Bacillosamine Biosynthesis in Bacterial Pathogens: Development of Inhibitors to a Bacterial Amino-Sugar Acetyltransferase from Campylobacter jejuni.Salicylate biosynthesis: overexpression, purification, and characterization of Irp9, a bifunctional salicylate synthase from Yersinia enterocolitica.Allosteric Targeting of the Fanconi Anemia Ubiquitin-Conjugating Enzyme Ube2T by Fragment Screening.Homo-PROTACs: bivalent small-molecule dimerizers of the VHL E3 ubiquitin ligase to induce self-degradation.Mind the Metal: A Fragment Library-Derived Zinc Impurity Binds the E2 Ubiquitin-Conjugating Enzyme Ube2T and Induces Structural Rearrangements.The crystal structure of Escherichia coli ketopantoate reductase with NADP+ bound.Group-Based Optimization of Potent and Cell-Active Inhibitors of the von Hippel-Lindau (VHL) E3 Ubiquitin Ligase: Structure-Activity Relationships Leading to the Chemical Probe (2S,4R)-1-((S)-2-(1-Cyanocyclopropanecarboxamido)-3,3-dimethylbutanoyl)-Target validation: Switching domains.Thioamide substitution to probe the hydroxyproline recognition of VHL ligands.Targeting Ligandable Pockets on Plant Homeodomain (PHD) Zinc Finger Domains by a Fragment-Based Approach.Bromodomain-peptide displacement assays for interactome mapping and inhibitor discoveryOptimization of a "bump-and-hole" approach to allele-selective BET bromodomain inhibition.
P50
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P50
description
hulumtues
@sq
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Alessio Ciulli
@ast
Alessio Ciulli
@en
Alessio Ciulli
@es
Alessio Ciulli
@nl
Alessio Ciulli
@sl
type
label
Alessio Ciulli
@ast
Alessio Ciulli
@en
Alessio Ciulli
@es
Alessio Ciulli
@nl
Alessio Ciulli
@sl
prefLabel
Alessio Ciulli
@ast
Alessio Ciulli
@en
Alessio Ciulli
@es
Alessio Ciulli
@nl
Alessio Ciulli
@sl
P1053
A-6279-2011
P106
P1153
8514807400
P21
P31
P3829
P496
0000-0002-8654-1670