Disruption of ligand binding to the insulin-like growth factor II/mannose 6-phosphate receptor by cancer-associated missense mutations.
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Tyrosine kinase signalling in breast cancer: insulin-like growth factors and their receptors in breast cancer.Binding of urokinase-type plasminogen activator receptor (uPAR) to the mannose 6-phosphate/insulin-like growth factor II receptor: contrasting interactions of full-length and soluble forms of uPARDominant-negative effect of truncated mannose 6-phosphate/insulin-like growth factor II receptor species in cancerM6P/IGF2R loss of heterozygosity in head and neck cancer associated with poor patient prognosisStructure of a functional IGF2R fragment determined from the anomalous scattering of sulfur.Epithelial-to-mesenchymal transition in breast cancer: a role for insulin-like growth factor I and insulin-like growth factor-binding protein 3?Mannose 6-phosphate receptors: new twists in the taleUse of big data in drug development for precision medicine.Identification of the insulin-like growth factor II receptor as a novel receptor for binding and invasion by Listeria monocytogenes.IGF2R missense single-nucleotide polymorphisms and breast cancer risk: the multiethnic cohort study.The IGF axis and hepatocarcinogenesis.Insulin-like growth factor-2 (IGF-2) activates estrogen receptor-α and -β via the IGF-1 and the insulin receptors in breast cancer cells.Exploring the transcriptome space of a recombinant BHK cell line through next generation sequencing.Keys to the hidden treasures of the mannose 6-phosphate/insulin-like growth factor 2 receptor.Targeting the insulin-like growth factor axis as a cancer therapy.Reactivation of the insulin-like growth factor-II signaling pathway in human hepatocellular carcinoma.Structure and function of the human Gly1619Arg polymorphism of M6P/IGF2R domain 11 implicated in IGF2 dependent growthHigh-affinity ligand binding by wild-type/mutant heteromeric complexes of the mannose 6-phosphate/insulin-like growth factor II receptor.IGF-IR signaling in epithelial to mesenchymal transition and targeting IGF-IR therapy: overview and new insightsInhibition of insulin-like growth factor II (IGF-II)-dependent cell growth by multidentate pentamannosyl 6-phosphate-based ligands targeting the mannose 6-phosphate/IGF-II receptor.Type I insulin-like growth factor receptor signaling in hematological malignancies.Targeting the insulin-like growth factor signaling pathway: figitumumab and other novel anticancer strategies.Identification of residues essential for carbohydrate recognition by the insulin-like growth factor II/mannose 6-phosphate receptor.Focal overexpression of insulin-like growth factor 2 by hepatocytes and cholangiocytes in viral liver cirrhosis.Domain interactions of the mannose 6-phosphate/insulin-like growth factor II receptor.M6P/IGF2R is mutated in squamous cell carcinoma of the lung.The mannose 6-phosphate-binding sites of M6P/IGF2R determine its capacity to suppress matrix invasion by squamous cell carcinoma cells.M6P/IGF2R modulates the invasiveness of liver cells via its capacity to bind mannose 6-phosphate residuesReal time kinetics of insulin-like growth factor II (IGF-II) interaction with the IGF-II/mannose 6-phosphate receptor: the effects of domain 13 and pH.Mechanisms for high affinity mannose 6-phosphate ligand binding to the insulin-like growth factor II/mannose 6-phosphate receptor.The mannose 6-phosphate/insulin-like growth factor II receptor restricts the tumourigenicity and invasiveness of squamous cell carcinoma cells.Cation-dependent mannose-6-phosphate receptor expression and distribution are influenced by estradiol in MCF-7 breast cancer cells
P2860
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P2860
Disruption of ligand binding to the insulin-like growth factor II/mannose 6-phosphate receptor by cancer-associated missense mutations.
description
1999 nî lūn-bûn
@nan
1999年の論文
@ja
1999年学术文章
@wuu
1999年学术文章
@zh
1999年学术文章
@zh-cn
1999年学术文章
@zh-hans
1999年学术文章
@zh-my
1999年学术文章
@zh-sg
1999年學術文章
@yue
1999年學術文章
@zh-hant
name
Disruption of ligand binding t ...... associated missense mutations.
@en
Disruption of ligand binding t ...... associated missense mutations.
@nl
type
label
Disruption of ligand binding t ...... associated missense mutations.
@en
Disruption of ligand binding t ...... associated missense mutations.
@nl
prefLabel
Disruption of ligand binding t ...... associated missense mutations.
@en
Disruption of ligand binding t ...... associated missense mutations.
@nl
P2093
P2860
P356
P1476
Disruption of ligand binding t ...... associated missense mutations.
@en
P2093
P2860
P304
24408-24416
P356
10.1074/JBC.274.34.24408
P407
P577
1999-08-01T00:00:00Z