Disrupted hepcidin regulation in HFE-associated haemochromatosis and the liver as a regulator of body iron homoeostasis.
about
Hemojuvelin and bone morphogenetic protein (BMP) signaling in iron homeostasisPhlebotomy for hereditary haemochromatosisCD81 promotes both the degradation of transferrin receptor 2 (TfR2) and the Tfr2-mediated maintenance of hepcidin expressionA mouse model of juvenile hemochromatosis.IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidinThe liver-specific microRNA miR-122 controls systemic iron homeostasis in miceErythropoietin administration in humans causes a marked and prolonged reduction in circulating hepcidinHereditary hemochromatosis in the post-HFE eraPathophysiology of hereditary hemochromatosisRecent advances in understanding haemochromatosis: a transition stateModulation of bone morphogenetic protein signaling in vivo regulates systemic iron balanceImpact of HFE genetic testing on clinical presentation of hereditary hemochromatosis: new epidemiological dataIron, anemia and hepcidin in malariaMechanisms of mammalian iron homeostasisModulation of hepcidin as therapy for primary and secondary iron overload disorders: preclinical models and approachesHepcidin expression in the liver: relatively low level in patients with chronic hepatitis CMolecular basis of HFE-hemochromatosis.Hepcidin and iron regulation, 10 years later.Iron imports. I. Intestinal iron absorption and its regulationEffects of strain and age on hepatic gene expression profiles in murine models of HFE-associated hereditary hemochromatosisIron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseasesGenetic disruption of NRF2 promotes the development of necroinflammation and liver fibrosis in a mouse model of HFE-hereditary hemochromatosisMutation in HFE gene decreases manganese accumulation and oxidative stress in the brain after olfactory manganese exposureContribution of Hfe expression in macrophages to the regulation of hepatic hepcidin levels and iron loadingChanges in the expression of intestinal iron transport and hepatic regulatory molecules explain the enhanced iron absorption associated with pregnancy in the ratEnhanced erythropoiesis in Hfe-KO mice indicates a role for Hfe in the modulation of erythroid iron homeostasisTwo BMP responsive elements, STAT, and bZIP/HNF4/COUP motifs of the hepcidin promoter are critical for BMP, SMAD1, and HJV responsivenessExome sequencing in HFE C282Y homozygous men with extreme phenotypes identifies a GNPAT variant associated with severe iron overload.The global prevalence of HFE and non-HFE hemochromatosis estimated from analysis of next-generation sequencing data.Effects of iron loading on muscle: genome-wide mRNA expression profiling in the mouseIron accumulation with age, oxidative stress and functional decline.ER stress-inducible factor CHOP affects the expression of hepcidin by modulating C/EBPalpha activityGlobal transcriptional response to Hfe deficiency and dietary iron overload in mouse liver and duodenumHigh-throughput matrix-assisted laser desorption ionization-time-of-flight mass spectrometry method for quantification of hepcidin in human urineRelationship between gene expression of duodenal iron transporters and iron stores in hemochromatosis subjects.Stoichiometries of transferrin receptors 1 and 2 in human liverFerroportin1 is required for normal iron cycling in zebrafishHepatocyte-targeted HFE and TFR2 control hepcidin expression in mice.Mass spectrometry analysis of hepcidin peptides in experimental mouse models.Iron uptake from plasma transferrin by a transferrin receptor 2 mutant mouse model of haemochromatosis.
P2860
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P2860
Disrupted hepcidin regulation in HFE-associated haemochromatosis and the liver as a regulator of body iron homoeostasis.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年学术文章
@wuu
2003年学术文章
@zh
2003年学术文章
@zh-cn
2003年学术文章
@zh-hans
2003年学术文章
@zh-my
2003年学术文章
@zh-sg
2003年學術文章
@yue
2003年學術文章
@zh-hant
name
Disrupted hepcidin regulation ...... tor of body iron homoeostasis.
@en
Disrupted hepcidin regulation ...... tor of body iron homoeostasis.
@nl
type
label
Disrupted hepcidin regulation ...... tor of body iron homoeostasis.
@en
Disrupted hepcidin regulation ...... tor of body iron homoeostasis.
@nl
prefLabel
Disrupted hepcidin regulation ...... tor of body iron homoeostasis.
@en
Disrupted hepcidin regulation ...... tor of body iron homoeostasis.
@nl
P2093
P50
P1433
P1476
Disrupted hepcidin regulation ...... ator of body iron homoeostasis
@en
P2093
Darrell H G Crawford
David M Purdie
Grant A Ramm
Jeanette L Dixon
Kim R Bridle
Lawrie W Powell
Sarah J Wilkins
P304
P356
10.1016/S0140-6736(03)12602-5
P407
P577
2003-02-01T00:00:00Z