Apurinic sites are position-specific topoisomerase II poisons.
about
Uracil-DNA glycosylase-DNA substrate and product structures: conformational strain promotes catalytic efficiency by coupled stereoelectronic effectsStructures of apurinic and apyrimidinic sites in duplex DNAsSensitivity of human type II topoisomerases to DNA damage: stimulation of enzyme-mediated DNA cleavage by abasic, oxidized and alkylated lesionsA diazirine-based photoaffinity etoposide probe for labeling topoisomerase II.A method for detecting abasic sites in living cells: age-dependent changes in base excision repairBase excision repair initiation revealed by crystal structures and binding kinetics of human uracil-DNA glycosylase with DNA.Distinct roles of Ape1 protein in the repair of DNA damage induced by ionizing radiation or bleomycin.Tdp2: a means to fixing the endsDNA topoisomerase II as a target for cancer chemotherapy.Contributions of the D-Ring to the activity of etoposide against human topoisomerase IIα: potential interactions with DNA in the ternary enzyme--drug--DNA complex.All tangled up: how cells direct, manage and exploit topoisomerase function.Activation of topoisomerase II-mediated excision of chromosomal DNA loops during oxidative stress.Removal of uracil by uracil DNA glycosylase limits pemetrexed cytotoxicity: overriding the limit with methoxyamine to inhibit base excision repair.Predictive value of topoisomerase IIalpha and other prognostic factors for epirubicin chemotherapy in advanced breast cancer.Association of CYP3A4 genotype with treatment-related leukemia.Topoisomerase II-mediated site-directed alkylation of DNA by psorospermin and its use in mapping other topoisomerase II poison binding sites.The geometry of DNA supercoils modulates topoisomerase-mediated DNA cleavage and enzyme response to anticancer drugs.Reversal of DNA damage induced Topoisomerase 2 DNA-protein crosslinks by Tdp2The DNA cleavage reaction of topoisomerase II: wolf in sheep's clothingDirect detection and quantification of abasic sites for in vivo studies of DNA damage and repair.Therapeutic intervention by the simultaneous inhibition of DNA repair and type I or type II DNA topoisomerases: one strategy, many outcomes.Human topoisomerase IIalpha possesses an intrinsic nucleic acid specificity for DNA ligation. Use of 5' covalently activated oligonucleotide substrates to study enzyme mechanism.Base excision repair intermediates as topoisomerase II poisons.Positioning the 3'-DNA terminus for topoisomerase II-mediated religation.Molecular analysis of yeast and human type II topoisomerases. Enzyme-DNA and drug interactions.In vitro evolution of preferred topoisomerase II DNA cleavage sites.Induction of topoisomerase I cleavage complexes by the vinyl chloride adduct 1,N6-ethenoadenine.Merbarone inhibits the catalytic activity of human topoisomerase IIalpha by blocking DNA cleavage.A two-drug model for etoposide action against human topoisomerase IIalpha.Replicative helicases can translocate through abasic site-induced covalent topoisomerase IV-DNA complexes.Mass Spectrometry-Based Tools to Characterize DNA-Protein Cross-Linking by Bis-Electrophiles.The topoisomerase II poison clerocidin alkylates non-paired guanines of DNA: implications for irreversible stimulation of DNA cleavage.Position-specific effect of ribonucleotides on the cleavage activity of human topoisomerase II.Hypersensitivity of nonhomologous DNA end-joining mutants to VP-16 and ICRF-193: implications for the repair of topoisomerase II-mediated DNA damage.Human topoisomerase IIalpha rapidly relaxes positively supercoiled DNA: implications for enzyme action ahead of replication forks.Direct and Topoisomerase II Mediated DNA Damage by Bis-3-chloropiperidines: The Importance of Being an Earnest G.Topoisomerase II site-directed alkylation of DNA by psorospermin and its effect on topoisomerase II-mediated DNA cleavage.
P2860
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P2860
Apurinic sites are position-specific topoisomerase II poisons.
description
1997 nî lūn-bûn
@nan
1997年の論文
@ja
1997年学术文章
@wuu
1997年学术文章
@zh
1997年学术文章
@zh-cn
1997年学术文章
@zh-hans
1997年学术文章
@zh-my
1997年学术文章
@zh-sg
1997年學術文章
@yue
1997年學術文章
@zh-hant
name
Apurinic sites are position-specific topoisomerase II poisons.
@en
Apurinic sites are position-specific topoisomerase II poisons.
@nl
type
label
Apurinic sites are position-specific topoisomerase II poisons.
@en
Apurinic sites are position-specific topoisomerase II poisons.
@nl
prefLabel
Apurinic sites are position-specific topoisomerase II poisons.
@en
Apurinic sites are position-specific topoisomerase II poisons.
@nl
P2860
P356
P1476
Apurinic sites are position-specific topoisomerase II poisons.
@en
P2093
P2860
P304
P356
10.1074/JBC.272.2.1148
P407
P577
1997-01-01T00:00:00Z