about
Identification of a novel domain in two mammalian inositol-polyphosphate 5-phosphatases that mediates membrane ruffle localization. The inositol 5-phosphatase skip localizes to the endoplasmic reticulum and translocates to membrane ruffles ...Identification of myotubularin as the lipid phosphatase catalytic subunit associated with the 3-phosphatase adapter protein, 3-PAPSilencer of death domains (SODD) inhibits skeletal muscle and kidney enriched inositol 5-phosphatase (SKIP) and regulates phosphoinositide 3-kinase (PI3K)/Akt signaling to the actin cytoskeletonFour and a half LIM protein 1: a partner for KCNA5 in human atriumThe type Ialpha inositol polyphosphate 4-phosphatase generates and terminates phosphoinositide 3-kinase signals on endosomes and the plasma membraneProteomic identification of FHL1 as the protein mutated in human reducing body myopathyThe SH2-containing inositol polyphosphate 5-phosphatase, SHIP-2, binds filamin and regulates submembraneous actinInositol polyphosphate 5-phosphatases; new players in the regulation of cilia and ciliopathiesThe yeast inositol polyphosphate 5-phosphatase Inp54p localizes to the endoplasmic reticulum via a C-terminal hydrophobic anchoring tail: regulation of secretion from the endoplasmic reticulum.Characterization of two isoforms of the skeletal muscle LIM protein 1, SLIM1. Localization of SLIM1 at focal adhesions and the isoform slimmer in the nucleus of myoblasts and cytoplasm of myotubes suggests distinct roles in the cytoskeleton and in nFour and a half LIM protein 1 binds myosin-binding protein C and regulates myosin filament formation and sarcomere assemblyFHL3 is an actin-binding protein that regulates alpha-actinin-mediated actin bundling: FHL3 localizes to actin stress fibers and enhances cell spreading and stress fiber disassemblyTBC domain family, member 15 is a novel mammalian Rab GTPase-activating protein with substrate preference for Rab7P-Rex1 - a multidomain protein that regulates neurite differentiationThe inositol polyphosphate 5-phosphatase, PIPP, Is a novel regulator of phosphoinositide 3-kinase-dependent neurite elongation.Distinct membrane and cytosolic forms of inositol polyphosphate 5-phosphatase II. Efficient membrane localization requires two discrete domainsRegulation of PI3K effector signalling in cancer by the phosphoinositide phosphatasesA mutation in synaptojanin 2 causes progressive hearing loss in the ENU-mutagenised mouse strain Mozart.Persistent mTORC1 signaling in cell senescence results from defects in amino acid and growth factor sensing.Characterization of an adapter subunit to a phosphatidylinositol (3)P 3-phosphatase: identification of a myotubularin-related protein lacking catalytic activityReactive oxygen species enhance insulin sensitivityInositol polyphosphate 4-phosphatase II regulates PI3K/Akt signaling and is lost in human basal-like breast cancersSec15 is an effector for the Rab11 GTPase in mammalian cells.Regulation of the transcriptional coactivator FHL2 licenses activation of the androgen receptor in castrate-resistant prostate cancer.Chromosomal mapping of the gene (INPP5A) encoding the 43-kDa membrane-associated inositol polyphosphate 5-phosphatase to 10q26.3 by fluorescence in situ hybridization.INPP5E interacts with AURKA, linking phosphoinositide signaling to primary cilium stabilityAutophosphorylation of serine 608 in the p85 regulatory subunit of wild type or cancer-associated mutants of phosphoinositide 3-kinase does not affect its lipid kinase activityFHL3 binds MyoD and negatively regulates myotube formation.Inositol polyphosphate 5-phosphatases: lipid phosphatases with flair.Identification of a proline-rich inositol polyphosphate 5-phosphatase (PIPP)•collapsin response mediator protein 2 (CRMP2) complex that regulates neurite elongation.FHL1 reduces dystrophy in transgenic mice overexpressing FSHD muscular dystrophy region gene 1 (FRG1).Identification of P-Rex1 as a novel Rac1-guanine nucleotide exchange factor (GEF) that promotes actin remodeling and GLUT4 protein trafficking in adipocytesThe Phosphatidylinositol (3,4,5)-Trisphosphate-dependent Rac Exchanger 1·Ras-related C3 Botulinum Toxin Substrate 1 (P-Rex1·Rac1) Complex Reveals the Basis of Rac1 Activation in Breast Cancer Cells.The Shc-binding site of the betac subunit of the GM-CSF/IL-3/IL-5 receptors is a negative regulator of hematopoiesisThe SH2 domain containing inositol polyphosphate 5-phosphatase-2: SHIP2.TCPTP regulates SFK and STAT3 signaling and is lost in triple-negative breast cancers.Regulation of phosphoinositide signaling by the inositol polyphosphate 5-phosphatases.The inositol polyphosphate 5-phosphatases: traffic controllers, waistline watchers and tumour suppressors?Identification of FHL1 as a regulator of skeletal muscle mass: implications for human myopathy.Clinical, histological and genetic characterization of reducing body myopathy caused by mutations in FHL1.
P50
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P50
description
haematologist and researcher
@en
onderzoeker
@nl
հետազոտող
@hy
name
Christina A Mitchell
@nl
Christina A Mitchell
@sl
Christina A. Mitchell
@en
Christina A. Mitchell
@es
كريستينا أ. ميتشيل
@ar
type
label
Christina A Mitchell
@nl
Christina A Mitchell
@sl
Christina A. Mitchell
@en
Christina A. Mitchell
@es
كريستينا أ. ميتشيل
@ar
altLabel
Christina Mitchell
@en
prefLabel
Christina A Mitchell
@nl
Christina A Mitchell
@sl
Christina A. Mitchell
@en
Christina A. Mitchell
@es
كريستينا أ. ميتشيل
@ar
P1153
7402387217
P166
P21
P31
P496
0000-0001-9372-3192