Inositol polyphosphate 4-phosphatase II regulates PI3K/Akt signaling and is lost in human basal-like breast cancers
about
Comprehensive molecular portraits of human breast tumoursPI3K/Akt/mTOR inhibitors in breast cancerPhosphatidylinositol 3-kinase and antiestrogen resistance in breast cancerPhosphoinositides: tiny lipids with giant impact on cell regulationPhosphoinositides: Key modulators of energy metabolismSignaling by the phosphoinositide 3-kinase family in immune cellsRole of the inositol polyphosphate-4-phosphatase type II Inpp4b in the generation of ovarian teratomasRegulation of PI3K effector signalling in cancer by the phosphoinositide phosphatasesSHIP2 multiple functions: a balance between a negative control of PtdIns(3,4,5)P₃ level, a positive control of PtdIns(3,4)P₂ production, and intrinsic docking properties.PI3K pathway activation in high-grade ductal carcinoma in situ--implications for progression to invasive breast carcinoma.PI(3,4)P2 plays critical roles in the regulation of focal adhesion dynamics of MDA-MB-231 breast cancer cellsPatient-derived xenografts of triple-negative breast cancer reproduce molecular features of patient tumors and respond to mTOR inhibition.Identification and use of biomarkers in treatment strategies for triple-negative breast cancer subtypes.Epigenetic inactivation of inositol polyphosphate 4-phosphatase B (INPP4B), a regulator of PI3K/AKT signaling pathway in EBV-associated nasopharyngeal carcinomaINPP4B: the new kid on the PI3K block.PTEN Tumor Suppressor Network in PI3K-Akt Pathway ControlGenetically engineered mouse models of PI3K signaling in breast cancer.Estrogen receptor alpha prevents bladder cancer via INPP4B inhibited akt pathway in vitro and in vivo.Determinants of the tumor suppressor INPP4B protein and lipid phosphatase activitiesIntegrative investigation on breast cancer in ER, PR and HER2-defined subgroups using mRNA and miRNA expression profiling.Microarray phosphatome profiling of breast cancer patients unveils a complex phosphatase regulatory role of the MAPK and PI3K pathways in estrogen receptor-negative breast cancersLinking signaling pathways to transcriptional programs in breast cancer.Micro-scale genomic DNA copy number aberrations as another means of mutagenesis in breast cancer.SGK3 mediates INPP4B-dependent PI3K signaling in breast cancerAn integrative analysis of PIK3CA mutation, PTEN, and INPP4B expression in terms of trastuzumab efficacy in HER2-positive breast cancerMetformin and erlotinib synergize to inhibit basal breast cancer.Discovery and development of small molecule SHIP phosphatase modulators.PI3K in cancer: divergent roles of isoforms, modes of activation and therapeutic targeting.Phosphatases: the new brakes for cancer development?An ShRNA Based Genetic Screen Identified Sesn2 as a Potential Tumor Suppressor in Lung Cancer via Suppression of Akt-mTOR-p70S6K SignalingElevated PI3K signaling drives multiple breast cancer subtypes.Comparative oncogenomics identifies breast tumors enriched in functional tumor-initiating cells.Loss of INPP4B causes a DNA repair defect through loss of BRCA1, ATM and ATR and can be targeted with PARP inhibitor treatment.In Vivo Role of INPP4B in Tumor and Metastasis Suppression through Regulation of PI3K-AKT Signaling at Endosomes.INPP4B Is a Tumor Suppressor in the Context of PTEN Deficiency.Mutations in the phosphatidylinositol 3-kinase pathway: role in tumor progression and therapeutic implications in breast cancer.Phosphatidylinositol 3-kinase pathway activation in breast cancer brain metastases.Basal-like Breast cancer DNA copy number losses identify genes involved in genomic instability, response to therapy, and patient survival.Integrated molecular pathway analysis informs a synergistic combination therapy targeting PTEN/PI3K and EGFR pathways for basal-like breast cancerA novel mass assay to quantify the bioactive lipid PtdIns3P in various biological samples
P2860
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P2860
Inositol polyphosphate 4-phosphatase II regulates PI3K/Akt signaling and is lost in human basal-like breast cancers
description
2010 nî lūn-bûn
@nan
2010 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Inositol polyphosphate 4-phosp ...... uman basal-like breast cancers
@ast
Inositol polyphosphate 4-phosp ...... uman basal-like breast cancers
@en
Inositol polyphosphate 4-phosp ...... uman basal-like breast cancers
@nl
type
label
Inositol polyphosphate 4-phosp ...... uman basal-like breast cancers
@ast
Inositol polyphosphate 4-phosp ...... uman basal-like breast cancers
@en
Inositol polyphosphate 4-phosp ...... uman basal-like breast cancers
@nl
prefLabel
Inositol polyphosphate 4-phosp ...... uman basal-like breast cancers
@ast
Inositol polyphosphate 4-phosp ...... uman basal-like breast cancers
@en
Inositol polyphosphate 4-phosp ...... uman basal-like breast cancers
@nl
P2093
P2860
P50
P356
P1476
Inositol polyphosphate 4-phosp ...... uman basal-like breast cancers
@en
P2093
Absorn Sriratana
Benjamin J Shields
Jessica Vieusseux
John E J Rasko
Laura Baglietto
Philip W Majerus
Rajendra Gurung
Robert L Sutherland
Sandra A O'Toole
P2860
P304
22231-22236
P356
10.1073/PNAS.1015245107
P407
P50
P577
2010-12-02T00:00:00Z