Transient PLK4 overexpression accelerates tumorigenesis in p53-deficient epidermis.
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Duplication of the Yeast Spindle Pole Body Once per Cell CycleStat3 regulates centrosome clustering in cancer cells via Stathmin/PLK1.Prognostic value of CA20, a score based on centrosome amplification-associated genes, in breast tumors.The PIDDosome activates p53 in response to supernumerary centrosomes.Centrosome amplification: a suspect in breast cancer and racial disparities.Emerging links among Chromosome Instability (CIN), cancer, and aging.Centrosome Amplification Is Sufficient to Promote Spontaneous Tumorigenesis in Mammals.Living in CIN: Mitotic Infidelity and Its Consequences for Tumor Promotion and Suppression.Dividing with Extra Centrosomes: A Double Edged Sword for Cancer Cells.The connections of Wnt pathway components with cell cycle and centrosome: side effects or a hidden logic?Cdk1 Phosphorylates Drosophila Sas-4 to Recruit Polo to Daughter Centrioles and Convert Them to Centrosomes.Oncogenic PIK3CA induces centrosome amplification and tolerance to genome doubling.Loss of E-cadherin provides tolerance to centrosome amplification in epithelial cancer cells.Building the right centriole for each cell type.When E-cadherin is away, centrosomes can play.PLK4: a link between centriole biogenesis and cancer.STIL balancing primary microcephaly and cancer.Once and only once: mechanisms of centriole duplication and their deregulation in disease.Structural centrosome aberrations promote non-cell-autonomous invasiveness.The SKP1-Cullin-F-box E3 ligase βTrCP and CDK2 cooperate to control STIL abundance and centriole number.Centrosome amplification arises before neoplasia and increases upon p53 loss in tumorigenesis.Structural centrosome aberrations sensitize polarized epithelia to basal cell extrusionCentrosome aberrations and chromosome instability contribute to tumorigenesis and intra-tumor heterogeneityYLT-11, a novel PLK4 inhibitor, inhibits human breast cancer growth via inducing maladjusted centriole duplication and mitotic defectPPP1R35 is a novel centrosomal protein that regulates centriole length in concert with the microcephaly protein RTTNChromosome structural anomalies due to aberrant spindle forces exerted at gene editing sites in meiosis
P2860
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P2860
Transient PLK4 overexpression accelerates tumorigenesis in p53-deficient epidermis.
description
2015 nî lūn-bûn
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2015年の論文
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2015年学术文章
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2015年学术文章
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name
Transient PLK4 overexpression accelerates tumorigenesis in p53-deficient epidermis.
@en
Transient PLK4 overexpression accelerates tumorigenesis in p53-deficient epidermis.
@nl
type
label
Transient PLK4 overexpression accelerates tumorigenesis in p53-deficient epidermis.
@en
Transient PLK4 overexpression accelerates tumorigenesis in p53-deficient epidermis.
@nl
prefLabel
Transient PLK4 overexpression accelerates tumorigenesis in p53-deficient epidermis.
@en
Transient PLK4 overexpression accelerates tumorigenesis in p53-deficient epidermis.
@nl
P2093
P356
P1433
P1476
Transient PLK4 overexpression accelerates tumorigenesis in p53-deficient epidermis.
@en
P2093
Andrea E Karambelas
Bram Boeckx
Cédric Blanpain
Jean-Christophe Larsimont
Marie Le Mercier
Renata Basto
Veronique Marthiens
Virginie Moers
Özdemirhan Serçin
P2888
P304
P356
10.1038/NCB3270
P577
2015-11-23T00:00:00Z