Distributions of selectively constrained sites and deleterious mutation rates in the hominid and murid genomes.
about
Human genetics and genomics a decade after the release of the draft sequence of the human genomeThe case for junk DNAWhat fraction of the human genome is functional?Evolution of the mutation rateRates and fitness consequences of new mutations in humansStrong purifying selection at synonymous sites in D. melanogasterMethods to detect selection on noncoding DNAGermline mutation rates and the long-term phenotypic effects of mutation accumulation in wild-type laboratory mice and mutator miceOrganizational heterogeneity of vertebrate genomesThe genome as a life-history character: why rate of molecular evolution varies between mammal speciesDetection of nonneutral substitution rates on mammalian phylogeniesRate, molecular spectrum, and consequences of human mutationThe evolution, impact and properties of exonic splice enhancers.Inference of site frequency spectra from high-throughput sequence data: quantification of selection on nonsynonymous and synonymous sites in humans.Surprising fitness consequences of GC-biased gene conversion: I. Mutation load and inbreeding depression.Genome-wide inference of natural selection on human transcription factor binding sites.Implications of human genome structural heterogeneity: functionally related genes tend to reside in organizationally similar genomic regions.Effective population size does not predict codon usage bias in mammalsKr/Kc but not dN/dS correlates positively with body mass in birds, raising implications for inferring lineage-specific selection.Inference of mutation parameters and selective constraint in mammalian coding sequences by approximate Bayesian computation.Faster than neutral evolution of constrained sequences: the complex interplay of mutational biases and weak selection.Contributions of protein-coding and regulatory change to adaptive molecular evolution in murid rodentsA genome-wide view of mutation rate co-variation using multivariate analyses.Causes of natural variation in fitness: evidence from studies of Drosophila populations.The role of the effective population size in compensatory evolution.Fitness Consequences of Advanced Ancestral Age over Three Generations in Humans.Estimating the Fitness Effects of New Mutations in the Wild Yeast Saccharomyces paradoxus.Why Selection Might Be Stronger When Populations Are Small: Intron Size and Density Predict within and between-Species Usage of Exonic Splice Associated cis-Motifs.Evidence for elevated mutation rates in low-quality genotypes.Assessing Recent Selection and Functionality at Long Noncoding RNA Loci in the Mouse Genome.The effect of variation in the effective population size on the rate of adaptive molecular evolution in eukaryotes.A resolution of the mutation load paradox in humansThe functional relevance of somatic synonymous mutations in melanoma and other cancers.Mutation load under additive fitness effects.Faster-X adaptive protein evolution in house mice.Molecular population genomics: a short history.Variation in the mutation rate across mammalian genomes.Current hypotheses for the evolution of sex and recombination.Cis-regulatory elements and human evolutionThe disparity mutagenesis model predicts rescue of living things from catastrophic errors.
P2860
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P2860
Distributions of selectively constrained sites and deleterious mutation rates in the hominid and murid genomes.
description
2010 nî lūn-bûn
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2010年の論文
@ja
2010年学术文章
@wuu
2010年学术文章
@zh
2010年学术文章
@zh-cn
2010年学术文章
@zh-hans
2010年学术文章
@zh-my
2010年学术文章
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2010年學術文章
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name
Distributions of selectively c ...... the hominid and murid genomes.
@en
Distributions of selectively c ...... the hominid and murid genomes.
@nl
type
label
Distributions of selectively c ...... the hominid and murid genomes.
@en
Distributions of selectively c ...... the hominid and murid genomes.
@nl
prefLabel
Distributions of selectively c ...... the hominid and murid genomes.
@en
Distributions of selectively c ...... the hominid and murid genomes.
@nl
P2860
P356
P1476
Distributions of selectively c ...... the hominid and murid genomes
@en
P2093
Peter D Keightley
P2860
P304
P356
10.1093/MOLBEV/MSP219
P577
2010-01-01T00:00:00Z