SMC6 is an essential gene in mice, but a hypomorphic mutant in the ATPase domain has a mild phenotype with a range of subtle abnormalities.
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Structural Insights into Ring Formation of Cohesin and Related Smc ComplexesDestabilized SMC5/6 complex leads to chromosome breakage syndrome with severe lung diseaseRole for rodent Smc6 in pericentromeric heterochromatin domains during spermatogonial differentiation and meiosis.Non-SMC elements 1 and 3 are required for early embryo and seedling development in Arabidopsis.The Smc5/6 Complex Restricts HBV when Localized to ND10 without Inducing an Innate Immune Response and Is Counteracted by the HBV X Protein Shortly after InfectionNSMCE2 suppresses cancer and aging in mice independently of its SUMO ligase activityChromatin association of the SMC5/6 complex is dependent on binding of its NSE3 subunit to DNA.Conditional mutation of Smc5 in mouse embryonic stem cells perturbs condensin localization and mitotic progressionEarly development of Drosophila embryos requires Smc5/6 function during oogenesis.Non-SMC Element 2 (NSMCE2) of the SMC5/6 Complex Helps to Resolve Topological Stress.SMC5/6 is required for the formation of segregation-competent bivalent chromosomes during meiosis I in mouse oocytes.Specialized interfaces of Smc5/6 control hinge stability and DNA association.Acute Smc5/6 depletion reveals its primary role in rDNA replication by restraining recombination at fork pausing sites.
P2860
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P2860
SMC6 is an essential gene in mice, but a hypomorphic mutant in the ATPase domain has a mild phenotype with a range of subtle abnormalities.
description
2013 nî lūn-bûn
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2013年の論文
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2013年学术文章
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SMC6 is an essential gene in m ...... range of subtle abnormalities.
@en
SMC6 is an essential gene in m ...... range of subtle abnormalities.
@nl
type
label
SMC6 is an essential gene in m ...... range of subtle abnormalities.
@en
SMC6 is an essential gene in m ...... range of subtle abnormalities.
@nl
prefLabel
SMC6 is an essential gene in m ...... range of subtle abnormalities.
@en
SMC6 is an essential gene in m ...... range of subtle abnormalities.
@nl
P2093
P50
P1433
P1476
SMC6 is an essential gene in m ...... range of subtle abnormalities.
@en
P2093
Alan R Lehmann
Andreas Zimmer
Birgit Rathkolb
Dirk H Busch
Helmut Fuchs
Ildikó Rácz
Johannes Beckers
Jonathan Wing
Marion Horsch
P304
P356
10.1016/J.DNAREP.2013.02.006
P50
P577
2013-03-18T00:00:00Z