Altered intrinsic neuronal excitability and reduced Na+ currents in a mouse model of Alzheimer's disease.
about
Intraneuronal Aβ accumulation induces hippocampal neuron hyperexcitability through A-type K(+) current inhibition mediated by activation of caspases and GSK-3.Low concentrations of the solvent dimethyl sulphoxide alter intrinsic excitability properties of cortical and hippocampal pyramidal cellsAugmented Inhibition from Cannabinoid-Sensitive Interneurons Diminishes CA1 Output after Traumatic Brain Injury.Alterations in synaptic plasticity coincide with deficits in spatial working memory in presymptomatic 3xTg-AD mice.Notoginsenoside R1 increases neuronal excitability and ameliorates synaptic and memory dysfunction following amyloid elevation.Inhibitory neuron and hippocampal circuit dysfunction in an aged mouse model of Alzheimer's disease.Preventing effect of L-type calcium channel blockade on electrophysiological alterations in dentate gyrus granule cells induced by entorhinal amyloid pathologyImpaired firing properties of dentate granule neurons in an Alzheimer's disease animal model are rescued by PPARγ agonism.Linking aβ42-induced hyperexcitability to neurodegeneration, learning and motor deficits, and a shorter lifespan in an Alzheimer's modelSoluble Aβ oligomers impair hippocampal LTP by disrupting glutamatergic/GABAergic balance.A new player in the "synaptopathy" of Alzheimer's disease - arc/arg 3.1.Can aging be 'drugged'?Characterization of altered intrinsic excitability in hippocampal CA1 pyramidal cells of the Aβ-overproducing PDAPP mouse.Intrinsic excitability changes induced by acute treatment of hippocampal CA1 pyramidal neurons with exogenous amyloid β peptide.Electrical and Network Neuronal Properties Are Preferentially Disrupted in Dorsal, But Not Ventral, Medial Entorhinal Cortex in a Mouse Model of Tauopathy.Altered intrinsic excitability of hippocampal CA1 pyramidal neurons in aged PDAPP mice.Dynamical systems analysis of spike-adding mechanisms in transient bursts.Neurophysiological modification of CA1 pyramidal neurons in a transgenic mouse expressing a truncated form of disrupted-in-schizophrenia 1CRISPR/Cas9-Correctable mutation-related molecular and physiological phenotypes in iPSC-derived Alzheimer's PSEN2 N141I neurons.Hippocampal neurophysiology is modified by a disease-associated C-terminal fragment of tau protein.Viscoelasticity of amyloid plaques in transgenic mouse brain studied by Brillouin microspectroscopy and correlative Raman analysis.Hippocampal GABAergic Inhibitory Interneurons.Continuation-based numerical detection of after-depolarization and spike-adding thresholds.Geometric analysis of transient bursts.
P2860
Q27307787-027A1FF3-F930-4A1B-94A4-4EA411665781Q28541170-4A254AE4-70C8-47C6-B1F5-38B7A1A56FACQ30609922-7430B9A7-E6AB-4297-AF24-006967FE367DQ30678146-36A23CF0-8D9C-48DF-8CAC-D05BAD10EFCAQ34169539-B4A22EB6-AD2D-4E25-8272-14D0C7B8D3FCQ34731447-341E18E4-28E5-4A52-B43A-4D6243CD7736Q35090883-A59AEDEA-A8FE-4EE8-81E5-C944E3217610Q35178508-14F1AEFB-CC54-42A5-B133-E24CF1EA03BFQ35578036-7BBA51BA-72F0-4251-BC3C-8ACC919E8BB4Q36652001-2A938511-7910-4231-A004-725711331C78Q38081344-AC80B331-B9B0-4271-AEB2-5D8AED8BF364Q38662550-2EA8AC47-7907-492C-BA32-5283F1F1D924Q38789229-4A7C16E6-BE78-4676-B280-D5BE7C985D1DQ38990572-0234A914-7D1F-4D03-A8AB-1588EDEFEB49Q40116083-6A0FD07A-96CD-4596-80F1-890AC44C04BCQ40362793-7753E7AC-D425-41B9-BBF0-148BA2B9BA6CQ41166165-E41F3F61-D790-45D6-8BFC-F4D126B7C35BQ41831982-1DBDC3B3-3603-4CA3-B4D2-9D1EA39D779FQ42517607-2B8F1D6E-DC23-4836-B9FD-2AA23B0AB215Q45927343-6E79451D-781B-4AA1-95F6-8CB7D1F11D09Q47139291-2B93D448-F303-495F-876B-2F9E67A734C2Q47734973-4ABBBAC5-D155-41E9-8DEC-AF6B21365D5AQ48199647-5B3236F5-7A9F-44D8-B189-47F72C8833FBQ51126493-493A9A1F-1936-46F1-8289-0787DD05ED2E
P2860
Altered intrinsic neuronal excitability and reduced Na+ currents in a mouse model of Alzheimer's disease.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年学术文章
@wuu
2011年学术文章
@zh
2011年学术文章
@zh-cn
2011年学术文章
@zh-hans
2011年学术文章
@zh-my
2011年学术文章
@zh-sg
2011年學術文章
@yue
2011年學術文章
@zh-hant
name
Altered intrinsic neuronal exc ...... model of Alzheimer's disease.
@en
Altered intrinsic neuronal exc ...... model of Alzheimer's disease.
@nl
type
label
Altered intrinsic neuronal exc ...... model of Alzheimer's disease.
@en
Altered intrinsic neuronal exc ...... model of Alzheimer's disease.
@nl
prefLabel
Altered intrinsic neuronal exc ...... model of Alzheimer's disease.
@en
Altered intrinsic neuronal exc ...... model of Alzheimer's disease.
@nl
P50
P1476
Altered intrinsic neuronal exc ...... e model of Alzheimer's disease
@en
P2093
Jeannie Chin
Menelas N Pangalos
P304
2109.e1-14
P356
10.1016/J.NEUROBIOLAGING.2011.05.025
P577
2011-07-27T00:00:00Z