Augmented cancer resistance and DNA damage response phenotypes in PPM1D null mice.
about
Wild-type p53-induced phosphatase 1 dephosphorylates histone variant gamma-H2AX and suppresses DNA double strand break repairA chemical inhibitor of PPM1D that selectively kills cells overexpressing PPM1D.The oncogenic phosphatase WIP1 negatively regulates nucleotide excision repairWIP1 phosphatase as pharmacological target in cancer therapy.Wip1 directly dephosphorylates gamma-H2AX and attenuates the DNA damage responsePPM1D silencing by RNA interference inhibits the proliferation of lung cancer cellsOverexpression of wip1 is associated with biologic behavior in human clear cell renal cell carcinoma.Deficiency of the tumor promoter gene wip1 induces insulin resistance.WIP1 phosphatase as a potential therapeutic target in neuroblastomaAbsence of Wip1 partially rescues Atm deficiency phenotypes in mice.Genetic characterization of breast cancer and implications for clinical managementHDM2 promotes WIP1-mediated medulloblastoma growth.PPM1D phosphatase, a target of p53 and RBM38 RNA-binding protein, inhibits p53 mRNA translation via dephosphorylation of RBM38.Gamma-H2AX upregulation caused by Wip1 deficiency increases depression-related cellular senescence in hippocampus.Molecular determinants of ovarian cancer chemoresistance: new insights into an old conundrumThe WIP1 oncogene promotes progression and invasion of aggressive medulloblastoma variantsWip1 and p53 contribute to HTLV-1 Tax-induced tumorigenesisThe type 2C phosphatase Wip1: an oncogenic regulator of tumor suppressor and DNA damage response pathways.WIP1 enhances tumor formation in a sonic hedgehog-dependent model of medulloblastoma.Association between overexpression of Wip1 and prognosis of patients with non-small cell lung cancerGain-of-function mutations of PPM1D/Wip1 impair the p53-dependent G1 checkpointGenetic variants and mutations of PPM1D control the response to DNA damage.Taking the time to make important decisions: the checkpoint effector kinases Chk1 and Chk2 and the DNA damage response.Wip1 abrogation decreases intestinal tumor frequency in APC(Min/+) mice irrespective of radiation quality.Dephosphorylation of γ-H2AX by WIP1: an important homeostatic regulatory event in DNA repair and cell cycle control.Wild-type p53-induced phosphatase 1 (Wip1) forestalls cellular premature senescence at physiological oxygen levels by regulating DNA damage response signaling during DNA replication.Checkpoint control and cancer.Crosstalk between the DNA damage response pathway and microRNAs.LZAP is a novel Wip1 binding partner and positive regulator of its phosphatase activity in vitro.PPM1D exerts its oncogenic properties in human pancreatic cancer through multiple mechanisms.Downregulation of Wip1 phosphatase modulates the cellular threshold of DNA damage signaling in mitosis.Wip1 confers G2 checkpoint recovery competence by counteracting p53-dependent transcriptional repression.Wip1 is associated with tumorigenity and metastasis through MMP-2 in human intrahepatic cholangiocarcinoma.WIP1 modulates responsiveness to Sonic Hedgehog signaling in neuronal precursor cells and medulloblastomaNovel role of Wip1 in p53-mediated cell homeostasis under non-stress conditions.Phosphorylation and degradation of MdmX is inhibited by Wip1 phosphatase in the DNA damage response.WIP1 phosphatase modulates the Hedgehog signaling by enhancing GLI1 function.p63 Silencing induces reprogramming of cardiac fibroblasts into cardiomyocyte-like cells.Targeting 17q23 amplicon to overcome the resistance to anti-HER2 therapy in HER2+ breast cancer
P2860
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P2860
Augmented cancer resistance and DNA damage response phenotypes in PPM1D null mice.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年学术文章
@wuu
2006年学术文章
@zh-cn
2006年学术文章
@zh-hans
2006年学术文章
@zh-my
2006年学术文章
@zh-sg
2006年學術文章
@yue
2006年學術文章
@zh
2006年學術文章
@zh-hant
name
Augmented cancer resistance and DNA damage response phenotypes in PPM1D null mice.
@en
Augmented cancer resistance and DNA damage response phenotypes in PPM1D null mice.
@nl
type
label
Augmented cancer resistance and DNA damage response phenotypes in PPM1D null mice.
@en
Augmented cancer resistance and DNA damage response phenotypes in PPM1D null mice.
@nl
prefLabel
Augmented cancer resistance and DNA damage response phenotypes in PPM1D null mice.
@en
Augmented cancer resistance and DNA damage response phenotypes in PPM1D null mice.
@nl
P2093
P356
P1476
Augmented cancer resistance and DNA damage response phenotypes in PPM1D null mice
@en
P2093
Bonnie Nannenga
Lawrence A Donehower
Marc Van Maanen
Melissa Dumble
Richard Sutton
T Rajendra Kumar
Xiongbin Lu
P304
P356
10.1002/MC.20195
P577
2006-08-01T00:00:00Z