Mutations in serines 15 and 20 of human p53 impair its apoptotic activity.
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Glycogen synthase kinase3 beta phosphorylates serine 33 of p53 and activates p53's transcriptional activityGene expression profile of human lung epithelial cells chronically exposed to single-walled carbon nanotubesCarbon nanotubes induce malignant transformation and tumorigenesis of human lung epithelial cellsp53 target gene AEN is a nuclear exonuclease required for p53-dependent apoptosisCritical roles for the serine 20, but not the serine 15, phosphorylation site and for the polyproline domain in regulating p53 turnoverWuho Is a New Member in Maintaining Genome Stability through its Interaction with Flap Endonuclease 1A role for c-Jun N-terminal kinase 1 (JNK1), but not JNK2, in the beta-amyloid-mediated stabilization of protein p53 and induction of the apoptotic cascade in cultured cortical neuronsPhosphorylation of Ser-20 mediates stabilization of human p53 in response to DNA damageCancer susceptibility polymorphism of p53 at codon 72 affects phosphorylation and degradation of p53 protein.Apoptosis and growth arrest induced by platinum compounds in U2-OS cells reflect a specific DNA damage recognition associated with a different p53-mediated response.Stoichiometric phosphorylation of human p53 at Ser315 stimulates p53-dependent transcription.Kinetics of p53 binding to promoter sites in vivo.A p53-independent role for the MDM2 antagonist Nutlin-3 in DNA damage response initiation.Regulation of the DNA Damage Response to DSBs by Post-Translational Modifications.The human vaccinia-related kinase 1 (VRK1) phosphorylates threonine-18 within the mdm-2 binding site of the p53 tumour suppressor protein.Jun NH2-terminal kinase phosphorylation of p53 on Thr-81 is important for p53 stabilization and transcriptional activities in response to stress.Dial 9-1-1 for p53: mechanisms of p53 activation by cellular stressRegulation of p53 by hypoxia: dissociation of transcriptional repression and apoptosis from p53-dependent transactivation.Strategies for manipulating the p53 pathway in the treatment of human cancer.DNA damage-induced apoptosis requires the DNA-dependent protein kinase, and is mediated by the latent population of p53.p53 Ser15 phosphorylation disrupts the p53-RPA70 complex and induces RPA70-mediated DNA repair in hypoxia.The p53 tumour suppressor protein.Mutation of mouse p53 Ser23 and the response to DNA damage.E2F1 induces phosphorylation of p53 that is coincident with p53 accumulation and apoptosis.Induction and bypass of p53 during productive infection by polyomavirusAttenuation of BPDE-induced p53 accumulation by TPA is associated with a decrease in stability and phosphorylation of p53 and downregulation of NFkappaB activation: role of p38 MAP kinase.Crippling p53 activities via knock-in mutations in mouse models.Flexible lid to the p53-binding domain of human Mdm2: implications for p53 regulation.ATM mutations in sporadic lymphoid tumours.A role for WRN in telomere-based DNA damage responses.Regulation of p53 responses by post-translational modifications.Inhibitor of apoptosis-stimulating protein of p53 (iASPP) is required for neuronal survival after axonal injury.Phosphorylation of murine p53 at ser-18 regulates the p53 responses to DNA damage.Phosphorylation of serine 18 regulates distinct p53 functions in miceCalpain-mediated processing of p53-associated parkin-like cytoplasmic protein (PARC) affects chemosensitivity of human ovarian cancer cells by promoting p53 subcellular trafficking.The critical role of catalase in prooxidant and antioxidant function of p53.FOXO3 signalling links ATM to the p53 apoptotic pathway following DNA damage.PRIMA-1 increases cisplatin sensitivity in chemoresistant ovarian cancer cells with p53 mutation: a requirement for Akt down-regulation.Role of p38 and JNK MAPK signaling pathways and tumor suppressor p53 on induction of apoptosis in response to Ad-eIF5A1 in A549 lung cancer cellsHow important are post-translational modifications in p53 for selectivity in target-gene transcription and tumour suppression?
P2860
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P2860
Mutations in serines 15 and 20 of human p53 impair its apoptotic activity.
description
1999 nî lūn-bûn
@nan
1999年の論文
@ja
1999年学术文章
@wuu
1999年学术文章
@zh
1999年学术文章
@zh-cn
1999年学术文章
@zh-hans
1999年学术文章
@zh-my
1999年学术文章
@zh-sg
1999年學術文章
@yue
1999年學術文章
@zh-hant
name
Mutations in serines 15 and 20 of human p53 impair its apoptotic activity.
@en
Mutations in serines 15 and 20 of human p53 impair its apoptotic activity.
@nl
type
label
Mutations in serines 15 and 20 of human p53 impair its apoptotic activity.
@en
Mutations in serines 15 and 20 of human p53 impair its apoptotic activity.
@nl
prefLabel
Mutations in serines 15 and 20 of human p53 impair its apoptotic activity.
@en
Mutations in serines 15 and 20 of human p53 impair its apoptotic activity.
@nl
P2093
P356
P1433
P1476
Mutations in serines 15 and 20 of human p53 impair its apoptotic activity
@en
P2093
P2888
P304
P356
10.1038/SJ.ONC.1202656
P407
P577
1999-05-01T00:00:00Z