Phosphorylation of serine 18 regulates distinct p53 functions in mice - Wikidata - awgldk - TriplyDB

Phosphorylation of serine 18 regulates distinct p53 functions in mice

Phosphorylation of serine 18 regulates distinct p53 functions in mice

http://www.wikidata.org/entity/Q35545143

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PPM1D dephosphorylates Chk1 and p53 and abrogates cell cycle checkpoints Multivalent binding of p53 to the STAGA complex mediates coactivator recruitment after UV damage Modulation of p53 activity by IkappaBalpha: evidence suggesting a common phylogeny between NF-kappaB and p53 transcription factors.Modeling the study of DNA damage responses in mice Posttranscriptional regulation of p53 and its targets by RNA-binding proteins Loss of p53 Ser18 and Atm results in embryonic lethality without cooperation in tumorigenesis Modes of p53 regulation Inositol pyrophosphates mediate the DNA-PK/ATM-p53 cell death pathway by regulating CK2 phosphorylation of Tti1/Tel2 Role of the translocation partner in protection against AID-dependent chromosomal translocations Phosphorylation of p53 serine 18 upregulates apoptosis to suppress Myc-induced tumorigenesis p53 C-terminal phosphorylation by CHK1 and CHK2 participates in the regulation of DNA-damage-induced C-terminal acetylation.Isoform-specific p73 knockout mice reveal a novel role for delta Np73 in the DNA damage response pathway Mouse models of p53 functions.Mutant TP53 posttranslational modifications: challenges and opportunities.Posttranslational modification of p53: cooperative integrators of function The p53 orchestra: Mdm2 and Mdmx set the tone In vivo analysis of p53 tumor suppressor function using genetically engineered mouse models ATM and Chk2-dependent phosphorylation of MDMX contribute to p53 activation after DNA damage.DNA repair synthesis and ligation affect the processing of excised oligonucleotides generated by human nucleotide excision repair.Mice defective in p53 nuclear localization signal 1 exhibit exencephaly.The pathological response to DNA damage does not contribute to p53-mediated tumour suppression.Phosphorylation of Daxx by ATM contributes to DNA damage-induced p53 activation.AMPKα1 deficiency promotes cellular proliferation and DNA damage via p21 reduction in mouse embryonic fibroblasts.Crippling p53 activities via knock-in mutations in mouse models.New insights into p53 activation Deficiency of the tumor promoter gene wip1 induces insulin resistance.Serine 312 phosphorylation is dispensable for wild-type p53 functions in vivo.MDM2 is required for suppression of apoptosis by activated Akt1 in salivary acinar cells.Brca2 deficiency leads to T cell loss and immune dysfunction.Augmented BMP signaling in the neural crest inhibits nasal cartilage morphogenesis by inducing p53-mediated apoptosis.p53 represses class switch recombination to IgG2a through its antioxidant function Mouse mutants reveal that putative protein interaction sites in the p53 proline-rich domain are dispensable for tumor suppression Pathways to motor incoordination: the inherited ataxias.ATM phosphorylation of Mdm2 Ser394 regulates the amplitude and duration of the DNA damage response in mice Phosphorylation at carboxyl-terminal S373 and S375 residues and 14-3-3 binding are not required for mouse p53 function Poly(ADP-ribose) polymerase inhibitors activate the p53 signaling pathway in neural stem/progenitor cells p53 N-terminal phosphorylation: a defining layer of complex regulation Dissecting p53 tumor suppressor function in vivo through the analysis of genetically modified mice.Mouse bites dogma: how mouse models are changing our views of how P53 is regulated in vivo.The p53 pathway in hematopoiesis: lessons from mouse models, implications for humans.

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P2860

Phosphorylation of serine 18 regulates distinct p53 functions in mice

http://www.wikidata.org/entity/Q35545143

description

2004 nî lūn-bûn

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2004 թուականի Փետրուարին հրատարակուած գիտական յօդուած

@hyw

2004 թվականի փետրվարին հրատարակված գիտական հոդված

@hy

2004年の論文

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2004年論文

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2004年論文

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2004年論文

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2004年論文

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2004年論文

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2004年论文

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name

Phosphorylation of serine 18 regulates distinct p53 functions in mice

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Phosphorylation of serine 18 regulates distinct p53 functions in mice

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Phosphorylation of serine 18 regulates distinct p53 functions in mice

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Phosphorylation of serine 18 regulates distinct p53 functions in mice

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Phosphorylation of serine 18 regulates distinct p53 functions in mice

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Phosphorylation of serine 18 regulates distinct p53 functions in mice

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MCB.24.3.976-984.2004

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Molecular and Cellular Biology

P1476

Phosphorylation of serine 18 regulates distinct p53 functions in mice

@en

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Hayla K Sluss

http://www.w3.org/2001/XMLSchema#string

Heather Armata

http://www.w3.org/2001/XMLSchema#string

Judy Gallant

http://www.w3.org/2001/XMLSchema#string

Stephen N Jones

http://www.w3.org/2001/XMLSchema#string

P2860

A role for ATR in the DNA damage-induced phosphorylation of p53

Compromised HOXA5 function can limit p53 expression in human breast tumours

Activation of the ATM kinase by ionizing radiation and phosphorylation of p53

The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases

Mdm2 promotes the rapid degradation of p53

Regulation of p53 function and stability by phosphorylation

The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites

Essential and dispensable roles of ATR in cell cycle arrest and genome maintenance

Regulation of p53 stability by Mdm2

WAF1, a potential mediator of p53 tumor suppression

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976-984

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10.1128/MCB.24.3.976-984.2004

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phosphorylation

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