Defective transport is a common mechanism of acquired methotrexate resistance in acute lymphocytic leukemia and is associated with decreased reduced folate carrier expression.
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The human reduced folate carrier gene is ubiquitously and differentially expressed in normal human tissues: identification of seven non-coding exons and characterization of a novel promoterA miR-24 microRNA binding-site polymorphism in dihydrofolate reductase gene leads to methotrexate resistanceA phase I study of nolatrexed dihydrochloride in children with advanced cancer. A United Kingdom Children's Cancer Study Group InvestigationThe redox state of cytochrome c modulates resistance to methotrexate in human MCF7 breast cancer cellsQuantitative correlation between promoter methylation and messenger RNA levels of the reduced folate carrierFolate pathway gene expression differs in subtypes of acute lymphoblastic leukemia and influences methotrexate pharmacodynamicsPhase II trial of pemetrexed plus bevacizumab for second-line therapy of patients with advanced non-small-cell lung cancer: NCCTG and SWOG study N0426.SLC19A1 pharmacogenomics summary.Structure and function of the reduced folate carrier a paradigm of a major facilitator superfamily mammalian nutrient transporter.The proton-coupled folate transporter: impact on pemetrexed transport and on antifolates activities compared with the reduced folate carrier.Expression of resistance markers to methotrexate predicts clinical improvement in patients with rheumatoid arthritisBiologic pathways associated with relapse in childhood acute lymphoblastic leukemia: a Children's Oncology Group study.Functional loss of the reduced folate carrier enhances the antitumor activities of novel antifolates with selective uptake by the proton-coupled folate transporter.Tyrosine phosphorylation of HSC70 and its interaction with RFC mediates methotrexate resistance in murine L1210 leukemia cells.Acquired variation outweighs inherited variation in whole genome analysis of methotrexate polyglutamate accumulation in leukemiaRoles of USF, Ikaros and Sp proteins in the transcriptional regulation of the human reduced folate carrier B promoter.Impairment of methotrexate transport is common in osteosarcoma tumor samplesCytoplasmic domains of the reduced folate carrier are essential for trafficking, but not function.Analysis of the membrane topology for transmembrane domains 7-12 of the human reduced folate carrier by scanning cysteine accessibility methods.Cancer chemotherapy: targeting folic acid synthesis.Correlation between polymorphisms of the reduced folate carrier gene (SLC19A1) and survival after pemetrexed-based therapy in non-small cell lung cancer: a North Central Cancer Treatment Group-based exploratory study.Transcript heterogeneity of the human reduced folate carrier results from the use of multiple promoters and variable splicing of alternative upstream exons.
P2860
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P2860
Defective transport is a common mechanism of acquired methotrexate resistance in acute lymphocytic leukemia and is associated with decreased reduced folate carrier expression.
description
1997 nî lūn-bûn
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1997年の論文
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1997年学术文章
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1997年学术文章
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name
Defective transport is a commo ...... ced folate carrier expression.
@en
Defective transport is a commo ...... ced folate carrier expression.
@nl
type
label
Defective transport is a commo ...... ced folate carrier expression.
@en
Defective transport is a commo ...... ced folate carrier expression.
@nl
prefLabel
Defective transport is a commo ...... ced folate carrier expression.
@en
Defective transport is a commo ...... ced folate carrier expression.
@nl
P2093
P1433
P1476
Defective transport is a commo ...... uced folate carrier expression
@en
P2093
Bertino JR
Elisseyeff Y
Flintoff WF
Mazumdar M
Steinherz P
Trippett T
P304
P407
P577
1997-02-01T00:00:00Z