The proton-coupled folate transporter: impact on pemetrexed transport and on antifolates activities compared with the reduced folate carrier.
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The human proton-coupled folate transporter (hPCFT): modulation of intestinal expression and function by drugsBiology of the major facilitative folate transporters SLC19A1 and SLC46A1Tumor and host factors that may limit efficacy of chemotherapy in non-small cell and small cell lung cancerMechanism of intestinal folate transport during folate deficiency in rodent modelVitamin D is not linked to folate status and mRNA expression of intestinal proton-coupled folate transporter.The role of folate receptor alpha (FRalpha) in the response of malignant pleural mesothelioma to pemetrexed-containing chemotherapy.Membrane topological analysis of the proton-coupled folate transporter (PCFT-SLC46A1) by the substituted cysteine accessibility method.The proton-coupled folate transporter: physiological and pharmacological roles.Properties of the Arg376 residue of the proton-coupled folate transporter (PCFT-SLC46A1) and a glutamine mutant causing hereditary folate malabsorptionMechanisms of membrane transport of folates into cells and across epithelia.Therapeutic targeting of a novel 6-substituted pyrrolo [2,3-d]pyrimidine thienoyl antifolate to human solid tumors based on selective uptake by the proton-coupled folate transporterIdentification and functional impact of homo-oligomers of the human proton-coupled folate transporter.Augmentation of reduced folate carrier-mediated folate/antifolate transport through an antiport mechanism with 5-aminoimidazole-4-carboxamide riboside monophosphateThe human proton-coupled folate transporter: Biology and therapeutic applications to cancer.Targeting the proton-coupled folate transporter for selective delivery of 6-substituted pyrrolo[2,3-d]pyrimidine antifolate inhibitors of de novo purine biosynthesis in the chemotherapy of solid tumors.Folate and thiamine transporters mediated by facilitative carriers (SLC19A1-3 and SLC46A1) and folate receptors.The intestinal absorption of folates.Functional roles of aspartate residues of the proton-coupled folate transporter (PCFT-SLC46A1); a D156Y mutation causing hereditary folate malabsorption.Membrane transporters and folate homeostasis: intestinal absorption and transport into systemic compartments and tissues.Vulnerability of the cysteine-less proton-coupled folate transporter (PCFT-SLC46A1) to mutational stress associated with the substituted cysteine accessibility method.Identification of novel mutations in the proton-coupled folate transporter (PCFT-SLC46A1) associated with hereditary folate malabsorptionHypermethylation of the human proton-coupled folate transporter (SLC46A1) minimal transcriptional regulatory region in an antifolate-resistant HeLa cell line.Assessment of the role of renal organic anion transporters in drug-induced nephrotoxicity.Identification of Tyr residues that enhance folate substrate binding and constrain oscillation of the proton-coupled folate transporter (PCFT-SLC46A1).Substrate- and pH-specific antifolate transport mediated by organic anion-transporting polypeptide 2B1 (OATP2B1-SLCO2B1)Contribution of tumoral and host solute carriers to clinical drug response.Functional loss of the reduced folate carrier enhances the antitumor activities of novel antifolates with selective uptake by the proton-coupled folate transporter.Identification of a functionally critical GXXG motif and its relationship to the folate binding site of the proton-coupled folate transporter (PCFT-SLC46A1)Expression in Sf9 insect cells, purification and functional reconstitution of the human proton-coupled folate transporter (PCFT, SLC46A1).6-Substituted Pyrrolo[2,3-d]pyrimidine Thienoyl Regioisomers as Targeted Antifolates for Folate Receptor α and the Proton-Coupled Folate Transporter in Human TumorsIdentification of an Extracellular Gate for the Proton-coupled Folate Transporter (PCFT-SLC46A1) by Cysteine Cross-linking.Reduced folate and serum vitamin metabolites in patients with rectal carcinoma: an open-label feasibility study of pemetrexed with folic acid and vitamin B12 supplementation.Inhibition of the proton-coupled folate transporter (PCFT-SLC46A1) by bicarbonate and other anions.A role for the proton-coupled folate transporter (PCFT-SLC46A1) in folate receptor-mediated endocytosis.Role of the tryptophan residues in proton-coupled folate transporter (PCFT-SLC46A1) function.Involvement of Multiple Transporters-mediated Transports in Mizoribine and Methotrexate Pharmacokinetics.Therapeutic targeting malignant mesothelioma with a novel 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl antifolate via its selective uptake by the proton-coupled folate transporter.The antifolatesThe membrane transport and polyglutamation of pralatrexate: a new-generation dihydrofolate reductase inhibitorRole of the glutamate 185 residue in proton translocation mediated by the proton-coupled folate transporter SLC46A1.
P2860
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P2860
The proton-coupled folate transporter: impact on pemetrexed transport and on antifolates activities compared with the reduced folate carrier.
description
2008 nî lūn-bûn
@nan
2008 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
The proton-coupled folate tran ...... th the reduced folate carrier.
@ast
The proton-coupled folate tran ...... th the reduced folate carrier.
@en
The proton-coupled folate tran ...... th the reduced folate carrier.
@nl
type
label
The proton-coupled folate tran ...... th the reduced folate carrier.
@ast
The proton-coupled folate tran ...... th the reduced folate carrier.
@en
The proton-coupled folate tran ...... th the reduced folate carrier.
@nl
prefLabel
The proton-coupled folate tran ...... th the reduced folate carrier.
@ast
The proton-coupled folate tran ...... th the reduced folate carrier.
@en
The proton-coupled folate tran ...... th the reduced folate carrier.
@nl
P2093
P2860
P356
P1476
The proton-coupled folate tran ...... th the reduced folate carrier.
@en
P2093
Andong Qiu
Eugenia Tsai
I David Goldman
Michaela Jansen
Myles H Akabas
Rongbao Zhao
P2860
P304
P356
10.1124/MOL.108.045443
P577
2008-06-04T00:00:00Z