Carcinogen testing: current problems and new approaches.
about
Mechanisms of multistep carcinogenesis and carcinogen risk assessmentApplication of integrated genetic monitoring: the optimal approach for detecting environmental carcinogensChemical carcinogens: a review of the science and its associated principles. U.S. Interagency Staff Group on CarcinogensAnimal Models of Chemical Carcinogenesis: Driving Breakthroughs in Cancer Research for 100 YearsScientific and Regulatory Policy Committee (SRPC) Review: Interpretation and Use of Cell Proliferation Data in Cancer Risk Assessment.A data-based assessment of alternative strategies for identification of potential human cancer hazards.Correlation of data from the strain A mouse bioassay with long-term bioassays.Mechanistic considerations in cancer risk assessment.Recent advances in in vivo genotoxicity testing: prediction of carcinogenic potential using comet and micronucleus assay in animal models.DNA damage-inducible genes as biomarkers for exposures to environmental agentsComparative evaluation of genetic toxicity patterns of carcinogens and noncarcinogens: strategies for predictive use of short-term assays.The traditional toxicologic paradigm is correct: dose influences mechanismNonlinearity of dose-response functions for carcinogenicityThe distinct health risk analyses required for genotoxic carcinogens and promoting agents.Oral contraceptive steroids as promoters or complete carcinogens for liver in female Sprague-Dawley rats.Tumor enhancers: underestimated factors in the epidemiology of lifestyle-associated cancers.Assessment of the carcinogenicity of the nonnutritive sweetener cyclamate.Induction of peroxisome proliferation and hepatic tumours in C57BL/6N mice by ciprofibrate, a hypolipidaemic compound.DNA damage related to increased hydrogen peroxide generation by hypolipidemic drug-induced liver peroxisomes.Risk assessment of carcinogenic and noncarcinogenic chemicals.History of chronic toxicity and animal carcinogenicity studies for pharmaceuticals.A critical assessment of the methodologies to investigate the role of inhibition of apoptosis in rodent hepatocarcinogenesis.Genotoxicity of organic extracts from atmospheric particles.Origin of the TTC values for compounds that are genotoxic and/or carcinogenic and an approach for their re-evaluation.Categorization of lipophilic xenobiotics by the enthalpic structure-function response of hepatic mixed-function oxidase.Strategies for determining the mechanisms of toxicity.Assessing the safety of drugs for the long-term treatment of peptic ulcers.Role of gene and chromosomal mutations in cell transformation.The role of the Scientific Committee for Food in evaluating plastics for packaging.Safety assessment of pharmaceuticals: examples of inadequate assessments and a mechanistic approach to assuring adequate assessment.Genotoxicity of a variety of hydrazine derivatives in the hepatocyte primary culture/DNA repair test using rat and mouse hepatocytes.Long-term mutagenicity studies with chloroform and dimethylnitrosamine in female lacI transgenic B6C3F1 mice.Distribution and macromolecular binding of benzo[a]pyrene in SENCAR and BALB/c mice following topical and oral administration.Determination of mutagenicity of the precipitate formed by sodium hypochlorite and chlorhexidine using the Ames test.Comparative assessment of DNA adduct formation, Salmonella mutagenicity, and chromosome aberration assays as short-term tests for DNA damage.Chemical carcinogens without mutagenic activity: peroxisome proliferators as a prototype.Carcinogenic potency and risk assessment.The importance of metabolite identification in quantitative risk estimation.High frequency of thyroid tumor induction by N-methyl-N'-nitro-N-nitrosoguanidine in the hermaphroditic fish Rivulus marmoratus.Survey of animal drugs with carcinogenic properties.
P2860
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P2860
Carcinogen testing: current problems and new approaches.
description
1981 nî lūn-bûn
@nan
1981年の論文
@ja
1981年学术文章
@wuu
1981年学术文章
@zh
1981年学术文章
@zh-cn
1981年学术文章
@zh-hans
1981年学术文章
@zh-my
1981年学术文章
@zh-sg
1981年學術文章
@yue
1981年學術文章
@zh-hant
name
Carcinogen testing: current problems and new approaches.
@en
Carcinogen testing: current problems and new approaches.
@nl
type
label
Carcinogen testing: current problems and new approaches.
@en
Carcinogen testing: current problems and new approaches.
@nl
prefLabel
Carcinogen testing: current problems and new approaches.
@en
Carcinogen testing: current problems and new approaches.
@nl
P356
P1433
P1476
Carcinogen testing: current problems and new approaches.
@en
P2093
Weisburger JH
Williams GM
P304
P356
10.1126/SCIENCE.7291981
P407
P577
1981-10-01T00:00:00Z