A pathway regulated by cell cycle inhibitor p27Kip1 and checkpoint inhibitor Smad3 is involved in the induction of T cell tolerance. - Wikidata - awgldk - TriplyDB

A pathway regulated by cell cycle inhibitor p27Kip1 and checkpoint inhibitor Smad3 is involved in the induction of T cell tolerance.

A pathway regulated by cell cycle inhibitor p27Kip1 and checkpoint inhibitor Smad3 is involved in the induction of T cell tolerance.

http://www.wikidata.org/entity/Q53596084

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Protein kinase C signaling and cell cycle regulation Molecular mechanisms for adaptive tolerance and other T cell anergy models A point mutation in the murine Hem1 gene reveals an essential role for Hematopoietic protein 1 in lymphopoiesis and innate immunity Meta-analysis followed by replication identifies loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with systemic lupus erythematosus in Asians The cell cycle time of CD8+ T cells responding in vivo is controlled by the type of antigenic stimulus.Solving the genetic puzzle of systemic lupus erythematosus.MicroRNA-150 modulates intracellular Ca 2+ levels in naïve CD8+ T cells by targeting TMEM20.The cyclin dependent kinase inhibitor (R)-roscovitine mediates selective suppression of alloreactive human T cells but preserves pathogen-specific and leukemia-specific effectors.HelicoVax: epitope-based therapeutic Helicobacter pylori vaccination in a mouse model TGF-β signalling is required for CD4⁺ T cell homeostasis but dispensable for regulatory T cell function.Roscovitine suppresses CD4+ T cells and T cell-mediated experimental uveitis.Regulation of T cell differentiation and alloimmunity by the cyclin-dependent kinase inhibitor p18ink4c Functional characterization of human T cell hyporesponsiveness induced by CTLA4-Ig.Functional blockade of the voltage-gated potassium channel Kv1.3 mediates reversion of T effector to central memory lymphocytes through SMAD3/p21cip1 signaling.Interleukin 2 gene transcription is regulated by Ikaros-induced changes in histone acetylation in anergic T cells.Transcriptional regulation of T cell tolerance.Tumor suppressor TSC1 is critical for T-cell anergy Cdk2 is critical for proliferation and self-renewal of neural progenitor cells in the adult subventricular zone Pathogenic implications for autoimmune mechanisms derived by comparative eQTL analysis of CD4+ versus CD8+ T cells.Cyclin-dependent kinase 2 controls peripheral immune tolerance Cyclin-dependent kinases: molecular switches controlling anergy and potential therapeutic targets for tolerance.mTOR at the crossroads of T cell proliferation and tolerance.Autophagy regulates T lymphocyte proliferation through selective degradation of the cell-cycle inhibitor CDKN1B/p27Kip1.A Systems Biology Approach to Characterize Biomarkers for Blood Stasis Syndrome of Unstable Angina Patients by Integrating MicroRNA and Messenger RNA Expression Profiling Negative regulators in homeostasis of naïve peripheral T cells.IL-2 signaling prevents T cell anergy by inhibiting the expression of anergy-inducing genes Tracking Differential Gene Expression in MRL/MpJ Versus C57BL/6 Anergic B Cells: Molecular Markers of Autoimmunity.The cyclin dependent kinase inhibitor (R)-roscovitine prevents alloreactive T cell clonal expansion and protects against acute GvHD Intrinsic and extrinsic control of peripheral T-cell tolerance by costimulatory molecules of the CD28/ B7 family K562 cell proliferation is modulated by PLCβ1 through a PKCα-mediated pathway.Transforming growth factor-{beta}-inducible phosphorylation of Smad3 Selective effects of PD-1 on Akt and Ras pathways regulate molecular components of the cell cycle and inhibit T cell proliferation.CTLA4Ig inhibits effector T cells through regulatory T cells and TGF-β.Release the ink4a/arf growth suppression by "u" and "me"?p27(Kip1) inhibits systemic autoimmunity through the control of Treg cell activity and differentiation.Sugars and fat - A healthy way to generate functional regulatory T cells.TGF-β in T Cell Biology: Implications for Cancer Immunotherapy.Autoimmunity in Coxsackievirus B3 induced myocarditis: role of estrogen in suppressing autoimmunity Simulation of Stimulation: Cytokine Dosage and Cell Cycle Crosstalk Driving Timing-Dependent T Cell Differentiation

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A pathway regulated by cell cycle inhibitor p27Kip1 and checkpoint inhibitor Smad3 is involved in the induction of T cell tolerance.

http://www.wikidata.org/entity/Q53596084

description

2006 nî lūn-bûn

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2006年の論文

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2006年学术文章

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2006年学术文章

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2006年学术文章

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2006年学术文章

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2006年学术文章

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2006年學術文章

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2006年學術文章

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2006年學術文章

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name

A pathway regulated by cell cy ...... induction of T cell tolerance.

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A pathway regulated by cell cy ...... induction of T cell tolerance.

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type

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A pathway regulated by cell cy ...... induction of T cell tolerance.

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A pathway regulated by cell cy ...... induction of T cell tolerance.

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prefLabel

A pathway regulated by cell cy ...... induction of T cell tolerance.

@en

A pathway regulated by cell cy ...... induction of T cell tolerance.

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Nature Immunology

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A pathway regulated by cell cy ...... induction of T cell tolerance.

@en

P2093

Alla Berezovskaya

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Lequn Li

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Vassiliki A Boussiotis

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Yoshiko Iwamoto

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P2860

Crystal structure of the p27Kip1 cyclin-dependent-kinase inhibitor bound to the cyclin A-Cdk2 complex

Assembly of cyclin D-dependent kinase and titration of p27Kip1 regulated by mitogen-activated protein kinase kinase (MEK1)

Targeted disruption of the mouse transforming growth factor-beta 1 gene results in multifocal inflammatory disease

Tob is a negative regulator of activation that is expressed in anergic and quiescent T cells

Direct binding of the signal-transducing adaptor Grb2 facilitates down-regulation of the cyclin-dependent kinase inhibitor p27Kip1

p27Kip1, a cyclin-Cdk inhibitor, links transforming growth factor-beta and contact inhibition to cell cycle arrest

Smad transcription factors

Targeted disruption of SMAD3 results in impaired mucosal immunity and diminished T cell responsiveness to TGF-beta

Mice lacking p27(Kip1) display increased body size, multiple organ hyperplasia, retinal dysplasia, and pituitary tumors

Evidence for a p27 tumor suppressive function independent of its role regulating cell proliferation in the prostate.

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1157-1165

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10.1038/NI1398

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11

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7

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17013388

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