Spontaneous and UV radiation-induced multiple metastatic melanomas in Cdk4R24C/R24C/TPras mice. - Wikidata - awgldk - TriplyDB

Spontaneous and UV radiation-induced multiple metastatic melanomas in Cdk4R24C/R24C/TPras mice.

Spontaneous and UV radiation-induced multiple metastatic melanomas in Cdk4R24C/R24C/TPras mice.

http://www.wikidata.org/entity/Q53632288

about

Reconstructing skin cancers using animal models Loss of CDKN2A expression is a frequent event in primary invasive melanoma and correlates with sensitivity to the CDK4/6 inhibitor PD0332991 in melanoma cell lines.Zebrafish have a competent p53-dependent nucleotide excision repair pathway to resolve ultraviolet B-induced DNA damage in the skin.Loss of nuclear receptor RXRα in epidermal keratinocytes promotes the formation of Cdk4-activated invasive melanomas.Hypoxia, melanocytes and melanoma - survival and tumor development in the permissive microenvironment of the skin.Cooperativity of Cdk4R24C and Ras in melanoma development.RXRα ablation in epidermal keratinocytes enhances UVR-induced DNA damage, apoptosis, and proliferation of keratinocytes and melanocytes.Dual suppression of the cyclin-dependent kinase inhibitors CDKN2C and CDKN1A in human melanoma.Pocket protein function in melanocyte homeostasis and neoplasia.Melanoma induction by ultraviolet A but not ultraviolet B radiation requires melanin pigment CDK4: A Key Player in the Cell Cycle, Development, and Cancer Cutaneous melanoma in genetically modified animals.Apoptotic cell death of human interstitial cells of Cajal.Increased cyclin D1 expression can mediate BRAF inhibitor resistance in BRAF V600E-mutated melanomas Cutaneous melanoma: how does ultraviolet light contribute to melanocyte transformation?Animal models of melanoma: a somatic cell gene delivery mouse model allows rapid evaluation of genes implicated in human melanoma.Mouse models of UV-induced melanoma: genetics, pathology, and clinical relevance.Mouse melanoma models and cell lines.p53 prevents progression of nevi to melanoma predominantly through cell cycle regulation Enhancement of DNA repair using topical T4 endonuclease V does not inhibit melanoma formation in Cdk4(R24C/R24C)/Tyr-Nras(Q61K) mice following neonatal UVR.Ablation of epidermal RXRα in cooperation with activated CDK4 and oncogenic NRAS generates spontaneous and acute neonatal UVB induced malignant metastatic melanomas.Neonatal UVB exposure accelerates melanoma growth and enhances distant metastases in Hgf-Cdk4(R24C) C57BL/6 mice.Differential roles of the pRb and Arf/p53 pathways in murine naevus and melanoma genesis.

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Spontaneous and UV radiation-induced multiple metastatic melanomas in Cdk4R24C/R24C/TPras mice.

http://www.wikidata.org/entity/Q53632288

description

2006 nî lūn-bûn

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2006年の論文

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2006年学术文章

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2006年学术文章

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2006年学术文章

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2006年学术文章

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2006年學術文章

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2006年學術文章

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2006年學術文章

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name

Spontaneous and UV radiation-i ...... s in Cdk4R24C/R24C/TPras mice.

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Spontaneous and UV radiation-i ...... s in Cdk4R24C/R24C/TPras mice.

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Spontaneous and UV radiation-i ...... s in Cdk4R24C/R24C/TPras mice.

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Spontaneous and UV radiation-i ...... s in Cdk4R24C/R24C/TPras mice.

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prefLabel

Spontaneous and UV radiation-i ...... s in Cdk4R24C/R24C/TPras mice.

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Spontaneous and UV radiation-i ...... s in Cdk4R24C/R24C/TPras mice.

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0008-5472.CAN-05-3196

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Cancer Research

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Spontaneous and UV radiation-i ...... s in Cdk4R24C/R24C/TPras mice.

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Brian Gabrielli

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Douglas Lincoln

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Graeme Walker

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H Konrad Muller

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Marianne Broome Powell

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Mariano Barbacid

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Nicholas Hayward

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Nicole Irwin

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2946-2952

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scholarly article

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10.1158/0008-5472.CAN-05-3196

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6

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66

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Marcos Malumbres

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2006-03-01T00:00:00Z

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16540642

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