Use of 4β-hydroxycholesterol in animal and human plasma samples as a biomarker for CYP3A induction.

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UHPLC-MS/MS bioanalysis of urinary DHEA, cortisone and their hydroxylated metabolites as potential biomarkers for CYP3A-mediated drug-drug interactions.Perspective: 4β-hydroxycholesterol as an emerging endogenous biomarker of hepatic CYP3A.

P2860

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Use of 4β-hydroxycholesterol in animal and human plasma samples as a biomarker for CYP3A induction.

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http://www.wikidata.org/entity/Q53804885

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2016 nî lūn-bûn

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2016年の論文

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2016年学术文章

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2016年学术文章

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2016年学术文章

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2016年学术文章

@zh-hans

2016年学术文章

@zh-my

2016年学术文章

@zh-sg

2016年學術文章

@yue

2016年學術文章

@zh-hant

name

Use of 4β-hydroxycholesterol i ...... biomarker for CYP3A induction.

@en

Use of 4β-hydroxycholesterol i ...... biomarker for CYP3A induction.

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type

Item

label

Use of 4β-hydroxycholesterol i ...... biomarker for CYP3A induction.

@en

Use of 4β-hydroxycholesterol i ...... biomarker for CYP3A induction.

@nl

prefLabel

Use of 4β-hydroxycholesterol i ...... biomarker for CYP3A induction.

@en

Use of 4β-hydroxycholesterol i ...... biomarker for CYP3A induction.

@nl

P1476

Use of 4β-hydroxycholesterol i ...... biomarker for CYP3A induction.

@en

P2093

Brian Melo

http://www.w3.org/2001/XMLSchema#string

Daniel Weiss

http://www.w3.org/2001/XMLSchema#string

Martha Vallejo

http://www.w3.org/2001/XMLSchema#string

Matthew Hoffmann

http://www.w3.org/2001/XMLSchema#string

Michael Thomas

http://www.w3.org/2001/XMLSchema#string

Sekhar Surapaneni

http://www.w3.org/2001/XMLSchema#string

Xinqun Irene Wu

http://www.w3.org/2001/XMLSchema#string

Y-J Xue

http://www.w3.org/2001/XMLSchema#string

Ying Ye

http://www.w3.org/2001/XMLSchema#string

Yong Liu

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P2860

Drug disposition and drug-drug interaction data in 2013 FDA new drug applications: a systematic review

Modeling of rifampicin-induced CYP3A4 activation dynamics for the prediction of clinical drug-drug interactions from in vitro data

A validated liquid chromatography-tandem mass spectrometry method for the quantitative determination of 4β-hydroxycholesterol in human plasma.

4β-Hydroxycholesterol, an endogenous marker of CYP3A4/5 activity in humans.

Quantitation of P450 3A4 endogenous biomarker - 4β-hydroxycholesterol - in human plasma using LC/ESI-MS/MS.

Species differences between mouse, rat, dog, monkey and human CYP-mediated drug metabolism, inhibition and induction.

A comparison of 4β-hydroxycholesterol : cholesterol and 6β-hydroxycortisol : cortisol as markers of CYP3A4 induction

Significant increase in plasma 4β-hydroxycholesterol concentration in patients after kidney transplantation.

Hepatic drug-metabolizing enzyme induction and implications for preclinical and clinical risk assessment.

Evaluation of pregnane X receptor (PXR)-mediated CYP3A4 drug-drug interactions in drug development.

P304

215-228

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P31

scholarly article

P356

10.4155/BIO.15.241

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2016-01-25T00:00:00Z

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P698

26805594

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Use of 4β-hydroxycholesterol in animal and human plasma samples as a biomarker for CYP3A induction.

about

P2860

P2860

Use of 4β-hydroxycholesterol in animal and human plasma samples as a biomarker for CYP3A induction.

description

name

type

label

prefLabel

P1433

P1476

P2093

P2860

P304

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P356

P433

P478

P577

P698

P356

P1433

P1476

P2093

P2860

P304

P31

P356

P433

P478

P577

P698