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A Review of the Updated Pharmacophore for the Alpha 5 GABA(A) Benzodiazepine Receptor ModelInteraction between the androgen receptor and a segment of its corepressor SHPEfficacy of a non-hypercalcemic vitamin-D2 derived anti-cancer agent (MT19c) and inhibition of fatty acid synthesis in an ovarian cancer xenograft modelHigh-throughput identification of promiscuous inhibitors from screening libraries with the use of a thiol-containing fluorescent probeSynthesis of highly substituted dibenzo[b,f]azocines and their evaluation as protein kinase inhibitors.Quantification of the vitamin D receptor-coregulator interactionInhibition of a viral enzyme by a small-molecule dimer disruptor.Identification and characterization of the first small molecule inhibitor of MDMXDifferential regulation of epidermal function by VDR coactivatorsGlo1 inhibitors for neuropsychiatric and anti-epileptic drug developmentAnticancer activity of VDR-coregulator inhibitor PS121912.Identification and analysis of hepatitis C virus NS3 helicase inhibitors using nucleic acid binding assaysMethylsulfonylnitrobenzoates, a new class of irreversible inhibitors of the interaction of the thyroid hormone receptor and its obligate coactivators that functionally antagonizes thyroid hormone.A fluorescence-based high throughput assay for the determination of small molecule-human serum albumin protein binding.An integrated in vitro and in vivo high-throughput screen identifies treatment leads for ependymoma.Inhibitors for the Vitamin D Receptor-Coregulator Interaction.Comparison of cell expression formats for the characterization of GABA(A) channels using a microfluidic patch clamp system.Antitumor Activity of 3-Indolylmethanamines 31B and PS121912.Synthesis and evaluation of vitamin D receptor-mediated activities of cholesterol and vitamin D metabolitesDevelopment of GABAA Receptor Subtype-Selective Imidazobenzodiazepines as Novel Asthma TreatmentsPeroxisome proliferation-activated receptor δ agonist GW0742 interacts weakly with multiple nuclear receptors, including the vitamin D receptor.Improvement of pharmacological properties of irreversible thyroid receptor coactivator binding inhibitors.PT19c, Another Nonhypercalcemic Vitamin D2 Derivative, Demonstrates Antitumor Efficacy in Epithelial Ovarian and Endometrial Cancer Models.Similarities and differences between two modes of antagonism of the thyroid hormone receptor.Further evaluation of the potential anxiolytic activity of imidazo[1,5-a][1,4]diazepin agents selective for α2/3-containing GABAA receptors.Pharmacological and antihyperalgesic properties of the novel α2/3 preferring GABAA receptor ligand MP-III-024.Calcitroic Acid-A Review.Development of novel Vitamin D Receptor-Coactivator InhibitorsDiscovery of the first irreversible small molecule inhibitors of the interaction between the vitamin D receptor and coactivatorsNovel flufenamic acid analogues as inhibitors of androgen receptor mediated transcriptionInhibitors of the interaction of a thyroid hormone receptor and coactivators: preliminary structure-activity relationships.Genetic and pharmacological manipulation of glyoxalase 1 regulates voluntary ethanol consumption in mice.Synthesis and Characterization of a Novel γ-Aminobutyric Acid Type A (GABAA) Receptor Ligand That Combines Outstanding Metabolic Stability, Pharmacokinetics, and Anxiolytic EfficacyIdentification of a novel, fast-acting GABAergic antidepressantIDENTIFICATION OF VDR ANTAGONISTS AMONG NUCLEAR RECEPTOR LIGANDS USING VIRTUAL SCREENINGSynthesis and characterization of BODIPY-labeled colchicine.A high-throughput ligand competition binding assay for the androgen receptor and other nuclear receptors.Hydrogen peroxide activated quinone methide precursors with enhanced DNA cross-linking capability and cytotoxicity towards cancer cells.Characterization of GABAA receptor ligands with automated patch-clamp using human neurons derived from pluripotent stem cellsCatalytic enantioselective synthesis of (-)-prostaglandin E1 methyl ester based on a tandem 1,4-addition-aldol reaction.
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wetenschapper
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հետազոտող
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Leggy A Arnold
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Leggy A Arnold
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Leggy A Arnold
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Leggy A Arnold
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Leggy A Arnold
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Leggy A Arnold
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Leggy A Arnold
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Leggy A Arnold
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P106
P31
P496
0000-0003-1411-1572