D-23129: a new anticonvulsant with a broad spectrum activity in animal models of epileptic seizures.
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Polarized axonal surface expression of neuronal KCNQ channels is mediated by multiple signals in the KCNQ2 and KCNQ3 C-terminal domainsDiscovery, Synthesis, and Structure–Activity Relationship of a Series of N -Aryl-bicyclo[2.2.1]heptane-2-carboxamides: Characterization of ML213 as a Novel KCNQ2 and KCNQ4 Potassium Channel OpenerNeural KCNQ (Kv7) channelsCharacterization of KCNQ5/Q3 potassium channels expressed in mammalian cellsDiverse mechanisms of antiepileptic drugs in the development pipelineMolecular targets for antiepileptic drug developmentRetigabine: has the orphan found a home?Preclinical antiepileptic actions of selective serotonin reuptake inhibitors--implications for clinical trial designNew and emerging treatments for epilepsy: review of clinical studies of lacosamide, eslicarbazepine acetate, ezogabine, rufinamide, perampanel, and electrical stimulation therapyHomeostasis or channelopathy? Acquired cell type-specific ion channel changes in temporal lobe epilepsy and their antiepileptic potentialPreclinical research in Rett syndrome: setting the foundation for translational success.Multiple-dose, linear, dose-proportional pharmacokinetics of retigabine in healthy volunteers.Is there a role for potassium channel openers in neuronal ion channel disorders?Activation of voltage-gated KCNQ/Kv7 channels by anticonvulsant retigabine attenuates mechanical allodynia of inflammatory temporomandibular joint in rats.New anti-epileptic drugs.Retigabine/Ezogabine, a KCNQ/K(V)7 channel opener: pharmacological and clinical data.Voltage-gated potassium channels at the crossroads of neuronal function, ischemic tolerance, and neurodegeneration.The pharmacology of imepitoin: the first partial benzodiazepine receptor agonist developed for the treatment of epilepsy.Vasorelaxant effects of novel Kv 7.4 channel enhancers ML213 and NS15370Potassium channels: how genetic studies of epileptic syndromes open paths to new therapeutic targets and drugs.Emerging drugs for epilepsy.Novel anticonvulsant medications in development.Ezogabine: a new angle on potassium gates.Oxidative modification of M-type K(+) channels as a mechanism of cytoprotective neuronal silencing.Profile of ezogabine (retigabine) and its potential as an adjunctive treatment for patients with partial-onset seizuresThe therapeutic potential of neuronal KCNQ channel modulators.Neuronal potassium channel openers in the management of epilepsy: role and potential of retigabine.Clinical utility of adjunctive retigabine in partial onset seizures in adults.Perspectives on treatment options for mesial temporal lobe epilepsy with hippocampal sclerosis.The Effects of the KCNQ Openers Retigabine and Flupirtine on Myotonia in Mammalian Skeletal Muscle Induced by a Chloride Channel Blocker.Clinical utility, safety, and tolerability of ezogabine (retigabine) in the treatment of epilepsy.Combinatorial augmentation of voltage-gated KCNQ potassium channels by chemical openers.Novel anticonvulsant drugs targeting voltage-dependent ion channels.One man's side effect is another man's therapeutic opportunity: targeting Kv7 channels in smooth muscle disorders.The new KCNQ2 activator 4-Chlor-N-(6-chlor-pyridin-3-yl)-benzamid displays anticonvulsant potential.Retigabine.Antiepileptogenic and antiictogenic effects of retigabine under conditions of rapid kindling: an ontogenic study.Inside job: ligand-receptor pharmacology beneath the plasma membrane.Enhancement of inhibitory neurotransmission and inhibition of excitatory mechanisms underlie the anticonvulsant effects of Mallotus oppositifolius.Rapid loss of efficacy to the antiseizure drugs lamotrigine and carbamazepine: a novel experimental model of pharmacoresistant epilepsy
P2860
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P2860
D-23129: a new anticonvulsant with a broad spectrum activity in animal models of epileptic seizures.
description
1996 nî lūn-bûn
@nan
1996年の論文
@ja
1996年学术文章
@wuu
1996年学术文章
@zh-cn
1996年学术文章
@zh-hans
1996年学术文章
@zh-my
1996年学术文章
@zh-sg
1996年學術文章
@yue
1996年學術文章
@zh
1996年學術文章
@zh-hant
name
D-23129: a new anticonvulsant ...... models of epileptic seizures.
@en
D-23129: a new anticonvulsant ...... models of epileptic seizures.
@nl
type
label
D-23129: a new anticonvulsant ...... models of epileptic seizures.
@en
D-23129: a new anticonvulsant ...... models of epileptic seizures.
@nl
prefLabel
D-23129: a new anticonvulsant ...... models of epileptic seizures.
@en
D-23129: a new anticonvulsant ...... models of epileptic seizures.
@nl
P2093
P1433
P1476
D-23129: a new anticonvulsant ...... models of epileptic seizures.
@en
P2093
B Kutscher
C Rundfeldt
E E Polymeropoulos
P304
P356
10.1016/0920-1211(95)00101-8
P577
1996-04-01T00:00:00Z