Acetaminophen-induced hepatic necrosis. V. Correlation of hepatic necrosis, covalent binding and glutathione depletion in hamsters.
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Acetylcysteine for acetaminophen poisoningProteomic approaches to characterize protein modifications: new tools to study the effects of environmental exposures.Evidence for cellular protein covalent binding derived from styrene metaboliteIntegrated proteomic and transcriptomic investigation of the acetaminophen toxicity in liver microfluidic biochipSelective protein arylation and acetaminophen-induced hepatotoxicity.Airway glutathione homeostasis is altered in children with severe asthma: evidence for oxidant stressN-acetylcysteine reduces the size and activity of von Willebrand factor in human plasma and miceApplication of pharmacokinetic principles in the extrapolation of animal data to humans.p-Aminophenol-induced liver toxicity: tentative evidence of a role for acetaminophen.Paracetamol (acetaminophen)-induced toxicity: molecular and biochemical mechanisms, analogues and protective approaches.Identification of the hepatic protein targets of reactive metabolites of acetaminophen in vivo in mice using two-dimensional gel electrophoresis and mass spectrometry.Differential effect of covalent protein modification and glutathione depletion on the transcriptional response of Nrf2 and NF-kappaB.Novel acetylcysteine regimens for treatment of paracetamol overdosePGE2-regulated wnt signaling and N-acetylcysteine are synergistically hepatoprotective in zebrafish acetaminophen injury.Effects of induction of cytochrome P-450 enzymes on the concentration of foreign compounds and their metabolites and on the toxicological effects of these compounds.The role of biotransformation in chemical-induced liver injury.Genetic aspects of toxicity during development.Bioactivation and covalent binding of halothane to liver macromolecules.Acetaminophen: a practical pharmacologic overview.Proteomic analysis of acetaminophen-induced changes in mitochondrial protein expression using spectral countingActivation of liver X receptor increases acetaminophen clearance and prevents its toxicity in mice.Liposome-encapsulated superoxide dismutase prevents liver necrosis induced by acetaminophen.Drug bioactivation, covalent binding to target proteins and toxicity relevance.Molecular aspects of paracetamol-induced hepatotoxicity and its mechanism-based prevention.Identification of novel toxicity-associated metabolites by metabolomics and mass isotopomer analysis of acetaminophen metabolism in wild-type and Cyp2e1-null mice.Does cytochrome P450 liver isoenzyme induction increase the risk of liver toxicity after paracetamol overdose?Satkara (Citrus macroptera) Fruit Protects against Acetaminophen-Induced Hepatorenal Toxicity in Rats.Redox Nanoparticle Therapeutics for Acetaminophen-Induced Hepatotoxicity in MiceAcetaminophen and acetylcysteine dose and duration: past, present and future.Species variation in the response of the cytochrome P-450-dependent monooxygenase system to inducers and inhibitors.The generation, detection, and effects of reactive drug metabolites.Allyl isothiocyanate (AITC) inhibits pregnane X receptor (PXR) and constitutive androstane receptor (CAR) activation and protects against acetaminophen- and amiodarone-induced cytotoxicity.Basic concepts in drug metabolism: Part II.Aromatic amino acetylation in the adult and neonatal marmoset [proceedings]The Ah locus: genetic regulation of the metabolism of carcinogens, drugs, and other environmental chemicals by cytochrome P-450-mediated monooxygenases.Chemical nature of reactive intermediates as determinant of toxicologic responses.The problem of chemically reactive metabolites.Pharmacokinetic considerations in toxicity testing.The non- and postenzymatic chemistry of N-oxygenated molecules.Keynote address: man, mice, microsomes, metabolites, and mathematics 40 years after the revolution.
P2860
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P2860
Acetaminophen-induced hepatic necrosis. V. Correlation of hepatic necrosis, covalent binding and glutathione depletion in hamsters.
description
1974 nî lūn-bûn
@nan
1974年の論文
@ja
1974年学术文章
@wuu
1974年学术文章
@zh-cn
1974年学术文章
@zh-hans
1974年学术文章
@zh-my
1974年学术文章
@zh-sg
1974年學術文章
@yue
1974年學術文章
@zh
1974年學術文章
@zh-hant
name
Acetaminophen-induced hepatic ...... athione depletion in hamsters.
@en
Acetaminophen-induced hepatic ...... athione depletion in hamsters.
@nl
type
label
Acetaminophen-induced hepatic ...... athione depletion in hamsters.
@en
Acetaminophen-induced hepatic ...... athione depletion in hamsters.
@nl
prefLabel
Acetaminophen-induced hepatic ...... athione depletion in hamsters.
@en
Acetaminophen-induced hepatic ...... athione depletion in hamsters.
@nl
P2093
P356
P1433
P1476
Acetaminophen-induced hepatic ...... athione depletion in hamsters.
@en
P2093
D J Jollow
J R Mitchell
S S Thorgeirsson
W Z Potter
P304
P356
10.1159/000136531
P577
1974-01-01T00:00:00Z